Immunogenicity of a virosomally-formulated Plasmodium falciparum GLURP-MSP3 chimeric protein-based malaria vaccine candidate in comparison to adjuvanted formulations
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Immunogenicity of a virosomally-formulated Plasmodium falciparum GLURP-MSP3 chimeric protein-based malaria vaccine candidate in comparison to adjuvanted formulations. / Tamborrini, Marco; Stoffel, Sabine A; Westerfeld, Nicole; Amacker, Mario; Theisen, Michael; Zurbriggen, Rinaldo; Pluschke, Gerd.
In: Malaria Journal, Vol. 10, 2011, p. 359.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Immunogenicity of a virosomally-formulated Plasmodium falciparum GLURP-MSP3 chimeric protein-based malaria vaccine candidate in comparison to adjuvanted formulations
AU - Tamborrini, Marco
AU - Stoffel, Sabine A
AU - Westerfeld, Nicole
AU - Amacker, Mario
AU - Theisen, Michael
AU - Zurbriggen, Rinaldo
AU - Pluschke, Gerd
PY - 2011
Y1 - 2011
N2 - In clinical trials, immunopotentiating reconstituted influenza virosomes (IRIVs) have shown great potential as a versatile antigen delivery platform for synthetic peptides derived from Plasmodium falciparum antigens. This study describes the immunogenicity of a virosomally-formulated recombinant fusion protein comprising domains of the two malaria vaccine candidate antigens MSP3 and GLURP.
AB - In clinical trials, immunopotentiating reconstituted influenza virosomes (IRIVs) have shown great potential as a versatile antigen delivery platform for synthetic peptides derived from Plasmodium falciparum antigens. This study describes the immunogenicity of a virosomally-formulated recombinant fusion protein comprising domains of the two malaria vaccine candidate antigens MSP3 and GLURP.
KW - Adjuvants, Immunologic
KW - Animals
KW - Antibodies, Protozoan
KW - Antigens, Protozoan
KW - Cross Reactions
KW - Immunoglobulin G
KW - Injections, Intramuscular
KW - Malaria Vaccines
KW - Mannitol
KW - Mice
KW - Oleic Acids
KW - Plasmodium falciparum
KW - Protozoan Proteins
KW - Recombinant Fusion Proteins
KW - Vaccines, Synthetic
KW - Vaccines, Virosome
U2 - 10.1186/1475-2875-10-359
DO - 10.1186/1475-2875-10-359
M3 - Journal article
C2 - 22166048
VL - 10
SP - 359
JO - Malaria Journal
JF - Malaria Journal
SN - 1475-2875
ER -
ID: 37835014