IgM, FcµRs, and malarial immune evasion

Research output: Contribution to journal › Journal article › Research › peer-review

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IgM, FcµRs, and malarial immune evasion. / Czajkowsky, Daniel M; Salanti, Ali; Ditlev, Sisse B; Shao, Zhifeng; Ghumra, Ashfaq; Rowe, J Alexandra; Pleass, Richard J.

In: Journal of Immunology, Vol. 184, No. 9, 2010, p. 4597-603.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Czajkowsky, DM, Salanti, A, Ditlev, SB, Shao, Z, Ghumra, A, Rowe, JA & Pleass, RJ 2010, 'IgM, FcµRs, and malarial immune evasion', Journal of Immunology, vol. 184, no. 9, pp. 4597-603. https://doi.org/10.4049/jimmunol.1000203

APA

Czajkowsky, D. M., Salanti, A., Ditlev, S. B., Shao, Z., Ghumra, A., Rowe, J. A., & Pleass, R. J. (2010). IgM, FcµRs, and malarial immune evasion. Journal of Immunology, 184(9), 4597-603. https://doi.org/10.4049/jimmunol.1000203

Vancouver

Czajkowsky DM, Salanti A, Ditlev SB, Shao Z, Ghumra A, Rowe JA et al. IgM, FcµRs, and malarial immune evasion. Journal of Immunology. 2010;184(9):4597-603. https://doi.org/10.4049/jimmunol.1000203

Author

Czajkowsky, Daniel M ; Salanti, Ali ; Ditlev, Sisse B ; Shao, Zhifeng ; Ghumra, Ashfaq ; Rowe, J Alexandra ; Pleass, Richard J. / IgM, FcµRs, and malarial immune evasion. In: Journal of Immunology. 2010 ; Vol. 184, No. 9. pp. 4597-603.

Bibtex

@article{861923b04f1b11df928f000ea68e967b,
title = "IgM, FcµRs, and malarial immune evasion",
abstract = "IgM is an ancestral Ab class found in all jawed vertebrates, from sharks to mammals. This ancient ancestry is shared by malaria parasites (genus Plasmodium) that infect all classes of terrestrial vertebrates with whom they coevolved. IgM, the least studied and most enigmatic of the vertebrate Igs, was recently shown to form an intimate relationship with the malaria parasite Plasmodium falciparum. In this article, we discuss how this association might have come about, building on the recently determined structure of the human IgM pentamer, and how this interaction could affect parasite survival, particularly in light of the just-discovered FcmicroR localized to B and T cell surfaces. Because this parasite may exploit an interaction with IgM to limit immune detection, as well as to manipulate the immune response when detected, a better understanding of this association may prove critical for the development of improved vaccines or vaccination strategies.",
author = "Czajkowsky, {Daniel M} and Ali Salanti and Ditlev, {Sisse B} and Zhifeng Shao and Ashfaq Ghumra and Rowe, {J Alexandra} and Pleass, {Richard J}",
year = "2010",
doi = "10.4049/jimmunol.1000203",
language = "English",
volume = "184",
pages = "4597--603",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "9",

}

RIS

TY - JOUR

T1 - IgM, FcµRs, and malarial immune evasion

AU - Czajkowsky, Daniel M

AU - Salanti, Ali

AU - Ditlev, Sisse B

AU - Shao, Zhifeng

AU - Ghumra, Ashfaq

AU - Rowe, J Alexandra

AU - Pleass, Richard J

PY - 2010

Y1 - 2010

N2 - IgM is an ancestral Ab class found in all jawed vertebrates, from sharks to mammals. This ancient ancestry is shared by malaria parasites (genus Plasmodium) that infect all classes of terrestrial vertebrates with whom they coevolved. IgM, the least studied and most enigmatic of the vertebrate Igs, was recently shown to form an intimate relationship with the malaria parasite Plasmodium falciparum. In this article, we discuss how this association might have come about, building on the recently determined structure of the human IgM pentamer, and how this interaction could affect parasite survival, particularly in light of the just-discovered FcmicroR localized to B and T cell surfaces. Because this parasite may exploit an interaction with IgM to limit immune detection, as well as to manipulate the immune response when detected, a better understanding of this association may prove critical for the development of improved vaccines or vaccination strategies.

AB - IgM is an ancestral Ab class found in all jawed vertebrates, from sharks to mammals. This ancient ancestry is shared by malaria parasites (genus Plasmodium) that infect all classes of terrestrial vertebrates with whom they coevolved. IgM, the least studied and most enigmatic of the vertebrate Igs, was recently shown to form an intimate relationship with the malaria parasite Plasmodium falciparum. In this article, we discuss how this association might have come about, building on the recently determined structure of the human IgM pentamer, and how this interaction could affect parasite survival, particularly in light of the just-discovered FcmicroR localized to B and T cell surfaces. Because this parasite may exploit an interaction with IgM to limit immune detection, as well as to manipulate the immune response when detected, a better understanding of this association may prove critical for the development of improved vaccines or vaccination strategies.

U2 - 10.4049/jimmunol.1000203

DO - 10.4049/jimmunol.1000203

M3 - Journal article

C2 - 20410497

VL - 184

SP - 4597

EP - 4603

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 9

ER -

ID: 19403397