IgG antibodies to endothelial protein C receptor-binding Cysteine-rich interdomain region domains of Plasmodium falciparum erythrocyte membrane protein 1 are acquired early in life in individuals exposed to malaria

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

IgG antibodies to endothelial protein C receptor-binding Cysteine-rich interdomain region domains of Plasmodium falciparum erythrocyte membrane protein 1 are acquired early in life in individuals exposed to malaria. / Turner, Louise; Lavstsen, Thomas; Mmbando, Bruno P; Wang, Christian W; Magistrado, Pamela A; Vestergaard, Lasse S; Ishengoma, Deus S; Minja, Daniel T R; Lusingu, John P; Theander, Thor G.

In: Infection and Immunity, Vol. 83, No. 8, 08.2015, p. 3096-103.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Turner, L, Lavstsen, T, Mmbando, BP, Wang, CW, Magistrado, PA, Vestergaard, LS, Ishengoma, DS, Minja, DTR, Lusingu, JP & Theander, TG 2015, 'IgG antibodies to endothelial protein C receptor-binding Cysteine-rich interdomain region domains of Plasmodium falciparum erythrocyte membrane protein 1 are acquired early in life in individuals exposed to malaria', Infection and Immunity, vol. 83, no. 8, pp. 3096-103. https://doi.org/10.1128/IAI.00271-15

APA

Turner, L., Lavstsen, T., Mmbando, B. P., Wang, C. W., Magistrado, P. A., Vestergaard, L. S., Ishengoma, D. S., Minja, D. T. R., Lusingu, J. P., & Theander, T. G. (2015). IgG antibodies to endothelial protein C receptor-binding Cysteine-rich interdomain region domains of Plasmodium falciparum erythrocyte membrane protein 1 are acquired early in life in individuals exposed to malaria. Infection and Immunity, 83(8), 3096-103. https://doi.org/10.1128/IAI.00271-15

Vancouver

Turner L, Lavstsen T, Mmbando BP, Wang CW, Magistrado PA, Vestergaard LS et al. IgG antibodies to endothelial protein C receptor-binding Cysteine-rich interdomain region domains of Plasmodium falciparum erythrocyte membrane protein 1 are acquired early in life in individuals exposed to malaria. Infection and Immunity. 2015 Aug;83(8):3096-103. https://doi.org/10.1128/IAI.00271-15

Author

Turner, Louise ; Lavstsen, Thomas ; Mmbando, Bruno P ; Wang, Christian W ; Magistrado, Pamela A ; Vestergaard, Lasse S ; Ishengoma, Deus S ; Minja, Daniel T R ; Lusingu, John P ; Theander, Thor G. / IgG antibodies to endothelial protein C receptor-binding Cysteine-rich interdomain region domains of Plasmodium falciparum erythrocyte membrane protein 1 are acquired early in life in individuals exposed to malaria. In: Infection and Immunity. 2015 ; Vol. 83, No. 8. pp. 3096-103.

Bibtex

@article{32ffabe544c149d98daff69397dd3e8f,
title = "IgG antibodies to endothelial protein C receptor-binding Cysteine-rich interdomain region domains of Plasmodium falciparum erythrocyte membrane protein 1 are acquired early in life in individuals exposed to malaria",
abstract = "Severe malaria syndromes are precipitated by Plasmodium falciparum parasites binding to endothelial receptors on the vascular lining. This binding is mediated by members of the highly variant P. falciparum erythrocyte membrane protein 1 (PfEMP1) family. We have previously identified a subset of PfEMP1 proteins associated with severe malaria and found that the receptor for these PfEMP1 variants is endothelial protein C receptor (EPCR). The binding is mediated through the amino-terminal cysteine-rich interdomain region (CIDR) of the subtypes α1.1 and α1.4 to α1.8. In this study, we investigated the acquisition of anti-CIDR antibodies using plasma samples collected in four study villages with different malaria transmission intensities in northeastern Tanzania during a period with a decline in malaria transmission. We show that individuals exposed to high levels of malaria transmission acquire antibodies to EPCR-binding CIDR domains early in life and that these antibodies are acquired more rapidly than antibodies to other CIDR domains. The rate by which antibodies to EPCR-binding CIDR domains are acquired in populations in areas where malaria is endemic is determined by the malaria transmission intensity, and on a population level, the antibodies are rapidly lost if transmission is interrupted. This indicates that sustained exposure is required to maintain the production of the antibodies.",
author = "Louise Turner and Thomas Lavstsen and Mmbando, {Bruno P} and Wang, {Christian W} and Magistrado, {Pamela A} and Vestergaard, {Lasse S} and Ishengoma, {Deus S} and Minja, {Daniel T R} and Lusingu, {John P} and Theander, {Thor G}",
note = "Copyright {\textcopyright} 2015, American Society for Microbiology. All Rights Reserved.",
year = "2015",
month = aug,
doi = "10.1128/IAI.00271-15",
language = "English",
volume = "83",
pages = "3096--103",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "8",

}

RIS

TY - JOUR

T1 - IgG antibodies to endothelial protein C receptor-binding Cysteine-rich interdomain region domains of Plasmodium falciparum erythrocyte membrane protein 1 are acquired early in life in individuals exposed to malaria

AU - Turner, Louise

AU - Lavstsen, Thomas

AU - Mmbando, Bruno P

AU - Wang, Christian W

AU - Magistrado, Pamela A

AU - Vestergaard, Lasse S

AU - Ishengoma, Deus S

AU - Minja, Daniel T R

AU - Lusingu, John P

AU - Theander, Thor G

N1 - Copyright © 2015, American Society for Microbiology. All Rights Reserved.

PY - 2015/8

Y1 - 2015/8

N2 - Severe malaria syndromes are precipitated by Plasmodium falciparum parasites binding to endothelial receptors on the vascular lining. This binding is mediated by members of the highly variant P. falciparum erythrocyte membrane protein 1 (PfEMP1) family. We have previously identified a subset of PfEMP1 proteins associated with severe malaria and found that the receptor for these PfEMP1 variants is endothelial protein C receptor (EPCR). The binding is mediated through the amino-terminal cysteine-rich interdomain region (CIDR) of the subtypes α1.1 and α1.4 to α1.8. In this study, we investigated the acquisition of anti-CIDR antibodies using plasma samples collected in four study villages with different malaria transmission intensities in northeastern Tanzania during a period with a decline in malaria transmission. We show that individuals exposed to high levels of malaria transmission acquire antibodies to EPCR-binding CIDR domains early in life and that these antibodies are acquired more rapidly than antibodies to other CIDR domains. The rate by which antibodies to EPCR-binding CIDR domains are acquired in populations in areas where malaria is endemic is determined by the malaria transmission intensity, and on a population level, the antibodies are rapidly lost if transmission is interrupted. This indicates that sustained exposure is required to maintain the production of the antibodies.

AB - Severe malaria syndromes are precipitated by Plasmodium falciparum parasites binding to endothelial receptors on the vascular lining. This binding is mediated by members of the highly variant P. falciparum erythrocyte membrane protein 1 (PfEMP1) family. We have previously identified a subset of PfEMP1 proteins associated with severe malaria and found that the receptor for these PfEMP1 variants is endothelial protein C receptor (EPCR). The binding is mediated through the amino-terminal cysteine-rich interdomain region (CIDR) of the subtypes α1.1 and α1.4 to α1.8. In this study, we investigated the acquisition of anti-CIDR antibodies using plasma samples collected in four study villages with different malaria transmission intensities in northeastern Tanzania during a period with a decline in malaria transmission. We show that individuals exposed to high levels of malaria transmission acquire antibodies to EPCR-binding CIDR domains early in life and that these antibodies are acquired more rapidly than antibodies to other CIDR domains. The rate by which antibodies to EPCR-binding CIDR domains are acquired in populations in areas where malaria is endemic is determined by the malaria transmission intensity, and on a population level, the antibodies are rapidly lost if transmission is interrupted. This indicates that sustained exposure is required to maintain the production of the antibodies.

U2 - 10.1128/IAI.00271-15

DO - 10.1128/IAI.00271-15

M3 - Journal article

C2 - 26015475

VL - 83

SP - 3096

EP - 3103

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 8

ER -

ID: 141212095