Identification of a Major Dimorphic Region in the Functionally Critical N-Terminal ID1 Domain of VAR2CSA

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Identification of a Major Dimorphic Region in the Functionally Critical N-Terminal ID1 Domain of VAR2CSA. / Doritchamou, Justin; Sabbagh, Audrey; Jespersen, Jakob S; Renard, Emmanuelle; Salanti, Ali; Nielsen, Morten A; Deloron, Philippe; Tuikue Ndam, Nicaise.

In: PLOS ONE, Vol. 10, No. 9, e0137695, 2015.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Doritchamou, J, Sabbagh, A, Jespersen, JS, Renard, E, Salanti, A, Nielsen, MA, Deloron, P & Tuikue Ndam, N 2015, 'Identification of a Major Dimorphic Region in the Functionally Critical N-Terminal ID1 Domain of VAR2CSA', PLOS ONE, vol. 10, no. 9, e0137695. https://doi.org/10.1371/journal.pone.0137695

APA

Doritchamou, J., Sabbagh, A., Jespersen, J. S., Renard, E., Salanti, A., Nielsen, M. A., Deloron, P., & Tuikue Ndam, N. (2015). Identification of a Major Dimorphic Region in the Functionally Critical N-Terminal ID1 Domain of VAR2CSA. PLOS ONE, 10(9), [e0137695]. https://doi.org/10.1371/journal.pone.0137695

Vancouver

Doritchamou J, Sabbagh A, Jespersen JS, Renard E, Salanti A, Nielsen MA et al. Identification of a Major Dimorphic Region in the Functionally Critical N-Terminal ID1 Domain of VAR2CSA. PLOS ONE. 2015;10(9). e0137695. https://doi.org/10.1371/journal.pone.0137695

Author

Doritchamou, Justin ; Sabbagh, Audrey ; Jespersen, Jakob S ; Renard, Emmanuelle ; Salanti, Ali ; Nielsen, Morten A ; Deloron, Philippe ; Tuikue Ndam, Nicaise. / Identification of a Major Dimorphic Region in the Functionally Critical N-Terminal ID1 Domain of VAR2CSA. In: PLOS ONE. 2015 ; Vol. 10, No. 9.

Bibtex

@article{cb39ccc41b064c4e8e1dbb6e770c1427,
title = "Identification of a Major Dimorphic Region in the Functionally Critical N-Terminal ID1 Domain of VAR2CSA",
abstract = "The VAR2CSA protein of Plasmodium falciparum is transported to and expressed on the infected erythrocyte surface where it plays a key role in placental malaria (PM). It is the current leading candidate for a vaccine to prevent PM. However, the antigenic polymorphism integral to VAR2CSA poses a challenge for vaccine development. Based on detailed analysis of polymorphisms in the sequence of its ligand-binding N-terminal region, currently the main focus for vaccine development, we assessed var2csa from parasite isolates infecting pregnant women. The results reveal for the first time the presence of a major dimorphic region in the functionally critical N-terminal ID1 domain. Parasite isolates expressing VAR2CSA with particular motifs present within this domain are associated with gravidity- and parasite density-related effects. These observations are of particular interest in guiding efforts with respect to optimization of the VAR2CSA-based vaccines currently under development.",
author = "Justin Doritchamou and Audrey Sabbagh and Jespersen, {Jakob S} and Emmanuelle Renard and Ali Salanti and Nielsen, {Morten A} and Philippe Deloron and {Tuikue Ndam}, Nicaise",
year = "2015",
doi = "10.1371/journal.pone.0137695",
language = "English",
volume = "10",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "9",

}

RIS

TY - JOUR

T1 - Identification of a Major Dimorphic Region in the Functionally Critical N-Terminal ID1 Domain of VAR2CSA

AU - Doritchamou, Justin

AU - Sabbagh, Audrey

AU - Jespersen, Jakob S

AU - Renard, Emmanuelle

AU - Salanti, Ali

AU - Nielsen, Morten A

AU - Deloron, Philippe

AU - Tuikue Ndam, Nicaise

PY - 2015

Y1 - 2015

N2 - The VAR2CSA protein of Plasmodium falciparum is transported to and expressed on the infected erythrocyte surface where it plays a key role in placental malaria (PM). It is the current leading candidate for a vaccine to prevent PM. However, the antigenic polymorphism integral to VAR2CSA poses a challenge for vaccine development. Based on detailed analysis of polymorphisms in the sequence of its ligand-binding N-terminal region, currently the main focus for vaccine development, we assessed var2csa from parasite isolates infecting pregnant women. The results reveal for the first time the presence of a major dimorphic region in the functionally critical N-terminal ID1 domain. Parasite isolates expressing VAR2CSA with particular motifs present within this domain are associated with gravidity- and parasite density-related effects. These observations are of particular interest in guiding efforts with respect to optimization of the VAR2CSA-based vaccines currently under development.

AB - The VAR2CSA protein of Plasmodium falciparum is transported to and expressed on the infected erythrocyte surface where it plays a key role in placental malaria (PM). It is the current leading candidate for a vaccine to prevent PM. However, the antigenic polymorphism integral to VAR2CSA poses a challenge for vaccine development. Based on detailed analysis of polymorphisms in the sequence of its ligand-binding N-terminal region, currently the main focus for vaccine development, we assessed var2csa from parasite isolates infecting pregnant women. The results reveal for the first time the presence of a major dimorphic region in the functionally critical N-terminal ID1 domain. Parasite isolates expressing VAR2CSA with particular motifs present within this domain are associated with gravidity- and parasite density-related effects. These observations are of particular interest in guiding efforts with respect to optimization of the VAR2CSA-based vaccines currently under development.

U2 - 10.1371/journal.pone.0137695

DO - 10.1371/journal.pone.0137695

M3 - Journal article

C2 - 26393516

VL - 10

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 9

M1 - e0137695

ER -

ID: 144536007