Human monoclonal IgG selection of Plasmodium falciparum for the expression of placental malaria-specific variant surface antigens
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Human monoclonal IgG selection of Plasmodium falciparum for the expression of placental malaria-specific variant surface antigens. / Soerli, J; Barfod, L; Lavstsen, T; Bernasconi, N L; Lanzavecchia, A; Hviid, L.
In: Parasite Immunology, Vol. 31, No. 6, 2009, p. 341-6.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Human monoclonal IgG selection of Plasmodium falciparum for the expression of placental malaria-specific variant surface antigens
AU - Soerli, J
AU - Barfod, L
AU - Lavstsen, T
AU - Bernasconi, N L
AU - Lanzavecchia, A
AU - Hviid, L
PY - 2009
Y1 - 2009
N2 - Pregnancy-associated Plasmodium falciparum malaria (PAM) is a major cause of morbidity and mortality in African women and their offspring. PAM is characterized by accumulation of infected erythrocytes (IEs) that adhere to chondroitin sulphate A (CSA) in the placental intervillous space. We show here that human monoclonal IgG antibodies with specificity for variant surface antigens (VSA) specifically expressed by CSA-adhering IEs (VSAPAM) can be used in vitro to select parasites from nonpregnant donors to express VSAPAM and that this selection for VSAPAM expression results in preferential transcription of var2csa. The results corroborate current efforts to develop PAM-specific vaccines based on VAR2CSA.
AB - Pregnancy-associated Plasmodium falciparum malaria (PAM) is a major cause of morbidity and mortality in African women and their offspring. PAM is characterized by accumulation of infected erythrocytes (IEs) that adhere to chondroitin sulphate A (CSA) in the placental intervillous space. We show here that human monoclonal IgG antibodies with specificity for variant surface antigens (VSA) specifically expressed by CSA-adhering IEs (VSAPAM) can be used in vitro to select parasites from nonpregnant donors to express VSAPAM and that this selection for VSAPAM expression results in preferential transcription of var2csa. The results corroborate current efforts to develop PAM-specific vaccines based on VAR2CSA.
U2 - 10.1111/j.1365-3024.2009.01097.x
DO - 10.1111/j.1365-3024.2009.01097.x
M3 - Journal article
C2 - 19493213
VL - 31
SP - 341
EP - 346
JO - Parasite Immunology
JF - Parasite Immunology
SN - 0141-9838
IS - 6
ER -
ID: 12869866