Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum
Research output: Contribution to journal › Journal article › Research › peer-review
Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-1(19) are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.
| Original language | English |
|---|---|
| Journal | Infection and Immunity |
| Volume | 69 |
| Issue number | 2 |
| Pages (from-to) | 1207-11 |
| Number of pages | 4 |
| ISSN | 0019-9567 |
| DOIs | |
| Publication status | Published - 2001 |
Bibliographical note
Keywords: Adolescent; Adult; Aged; Animals; Antibodies, Protozoan; Child; Child, Preschool; Humans; Immunoglobulin G; Infant; Merozoite Surface Protein 1; Middle Aged; Peptide Fragments; Plasmodium falciparum
ID: 6747323