Clustering of malaria treatment failure (TF) in Daraweesh: hints for host genetic susceptibility to TF with emphasis on immune-modulating SNPs
Research output: Contribution to journal › Journal article › Research › peer-review
In malaria, drug resistance and treatment failure (TF) are not synonymous, although are escalating together. Over 9 years of surveillances for malaria morbidity and TF in Daraweesh village in eastern Sudan (1991-2004), 136 donors (15-78 years) from 43 households, treated for 278 malaria episodes and had experienced 46 incident of TF, were included in this study. Blood obtained from the donors in 2005, was used for measurement of IgG subclasses against Pf332-C231 antigen and GM/KM allotyping and for genotyping of the donors for; FcgammaRIIA 131 (HH, RH, RR), CRP 286 (C
| Original language | English |
|---|---|
| Journal | Infection, Genetics and Evolution |
| Volume | 10 |
| Issue number | 4 |
| Pages (from-to) | 481-6 |
| Number of pages | 5 |
| ISSN | 1567-1348 |
| DOIs | |
| Publication status | Published - 2010 |
Bibliographical note
Keywords: Adolescent; Adult; Antibodies, Protozoan; Antimalarials; Chi-Square Distribution; Chloroquine; Cluster Analysis; Female; Genetic Predisposition to Disease; Host-Parasite Interactions; Humans; Immunoglobulin G; Malaria, Falciparum; Male; Plasmodium falciparum; Polymorphism, Single Nucleotide; Statistics, Nonparametric; Sudan; Treatment Failure
ID: 21521915