Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1-based vaccines to prevent it
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Cerebral Plasmodium falciparum malaria : The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1-based vaccines to prevent it. / Jensen, Anja Ramstedt; Adams, Yvonne; Hviid, Lars.
In: Immunological Reviews, Vol. 293, No. 1, 2020, p. 230-252.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Cerebral Plasmodium falciparum malaria
T2 - The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1-based vaccines to prevent it
AU - Jensen, Anja Ramstedt
AU - Adams, Yvonne
AU - Hviid, Lars
PY - 2020
Y1 - 2020
N2 - Malaria, a mosquito-borne infectious disease caused by parasites of the genus Plasmodium continues to be a major health problem worldwide. The unicellular Plasmodium-parasites have the unique capacity to infect and replicate within host erythrocytes. By expressing variant surface antigens Plasmodium falciparum has evolved to avoid protective immune responses; as a result in endemic areas anti-malaria immunity develops gradually over many years of multiple and repeated infections. We are studying the role of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) expressed by asexual stages of P. falciparum responsible for the pathogenicity of severe malaria. The immunopathology of falciparum malaria has been linked to cyto-adhesion of infected erythrocytes to specific host receptors. A greater appreciation of the PfEMP1 molecules important for the development of protective immunity and immunopathology is a prerequisite for the rational discovery and development of a safe and protective anti-disease malaria vaccine. Here we review the role of ICAM-1 and EPCR receptor adhering falciparum-parasites in the development of severe malaria; we discuss our current research to understand the factors involved in the pathogenesis of cerebral malaria and the feasibility of developing a vaccine targeted specifically to prevent this disease.
AB - Malaria, a mosquito-borne infectious disease caused by parasites of the genus Plasmodium continues to be a major health problem worldwide. The unicellular Plasmodium-parasites have the unique capacity to infect and replicate within host erythrocytes. By expressing variant surface antigens Plasmodium falciparum has evolved to avoid protective immune responses; as a result in endemic areas anti-malaria immunity develops gradually over many years of multiple and repeated infections. We are studying the role of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) expressed by asexual stages of P. falciparum responsible for the pathogenicity of severe malaria. The immunopathology of falciparum malaria has been linked to cyto-adhesion of infected erythrocytes to specific host receptors. A greater appreciation of the PfEMP1 molecules important for the development of protective immunity and immunopathology is a prerequisite for the rational discovery and development of a safe and protective anti-disease malaria vaccine. Here we review the role of ICAM-1 and EPCR receptor adhering falciparum-parasites in the development of severe malaria; we discuss our current research to understand the factors involved in the pathogenesis of cerebral malaria and the feasibility of developing a vaccine targeted specifically to prevent this disease.
KW - antibodies
KW - cerebral malaria
KW - immunity
KW - PfEMP1
KW - Plasmodium falciparum
KW - vaccine
U2 - 10.1111/imr.12807
DO - 10.1111/imr.12807
M3 - Review
C2 - 31562653
AN - SCOPUS:85073987818
VL - 293
SP - 230
EP - 252
JO - Immunological Reviews
JF - Immunological Reviews
SN - 0105-2896
IS - 1
ER -
ID: 230148785