Biomarker of Anopheles exposure in Ghanaian children with hemoglobin S and C
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Biomarker of Anopheles exposure in Ghanaian children with hemoglobin S and C. / Londono-Renteria, Berlin; Seidu, Zakaria; Lamptey, Helena; Ofori, Michael F.; Hviid, Lars; Lopez-Perez, Mary.
In: Acta Tropica, Vol. 249, 107043, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Biomarker of Anopheles exposure in Ghanaian children with hemoglobin S and C
AU - Londono-Renteria, Berlin
AU - Seidu, Zakaria
AU - Lamptey, Helena
AU - Ofori, Michael F.
AU - Hviid, Lars
AU - Lopez-Perez, Mary
N1 - Publisher Copyright: © 2023 The Author(s)
PY - 2024
Y1 - 2024
N2 - Heterozygous carriers of hemoglobin S and C (HbAS and HbAC) have a reduced risk of severe malaria but are not protected from Plasmodium falciparum infection, suggesting that the protection involves acquired immunity. During a blood meal, female Anopheles mosquitoes inject saliva that can elicit a host antibody response, which can serve as a proxy for exposure to Plasmodium infection. Previous studies have shown that the peptide gSG6-P1 of An. gambiae saliva is antigenic and highly Anopheles specific. Here, we used plasma samples from 201 Ghanaian children with wild-type hemoglobin (HbAA), HbAS, and HbAC to evaluate antibody levels against gSG6-P1 as a serological biomarker of Anopheles exposure and, therefore of P. falciparum infection risk. Malaria antigen (PfCSP, GLURP, Pfs230, and HB3VAR06)-specific IgG levels, demographic data, and data regarding P. falciparum infection and malaria control practices were also analyzed. Children with active P. falciparum infection had higher antibody levels against all antigens, and those with HbAS and HbAC had significantly higher antibody levels against Pfs230. Pfs230-specific IgG correlated negatively with gSG6-P1-specific IgG in children with HbAC. Our results highlight the importance of studying the role of hemoglobinopathies in malaria transmission to improve control interventions.
AB - Heterozygous carriers of hemoglobin S and C (HbAS and HbAC) have a reduced risk of severe malaria but are not protected from Plasmodium falciparum infection, suggesting that the protection involves acquired immunity. During a blood meal, female Anopheles mosquitoes inject saliva that can elicit a host antibody response, which can serve as a proxy for exposure to Plasmodium infection. Previous studies have shown that the peptide gSG6-P1 of An. gambiae saliva is antigenic and highly Anopheles specific. Here, we used plasma samples from 201 Ghanaian children with wild-type hemoglobin (HbAA), HbAS, and HbAC to evaluate antibody levels against gSG6-P1 as a serological biomarker of Anopheles exposure and, therefore of P. falciparum infection risk. Malaria antigen (PfCSP, GLURP, Pfs230, and HB3VAR06)-specific IgG levels, demographic data, and data regarding P. falciparum infection and malaria control practices were also analyzed. Children with active P. falciparum infection had higher antibody levels against all antigens, and those with HbAS and HbAC had significantly higher antibody levels against Pfs230. Pfs230-specific IgG correlated negatively with gSG6-P1-specific IgG in children with HbAC. Our results highlight the importance of studying the role of hemoglobinopathies in malaria transmission to improve control interventions.
KW - Anopheles
KW - Antibody response
KW - Ghana
KW - gSG6-P1
KW - HbAC
KW - HbAS
KW - Malaria
U2 - 10.1016/j.actatropica.2023.107043
DO - 10.1016/j.actatropica.2023.107043
M3 - Journal article
AN - SCOPUS:85175431411
VL - 249
JO - Acta Tropica
JF - Acta Tropica
SN - 0001-706X
M1 - 107043
ER -
ID: 378959591