Anti-phospholipid antibodies in patients with Plasmodium falciparum malaria
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Anti-phospholipid antibodies in patients with Plasmodium falciparum malaria. / Jakobsen, P H; Morris-Jones, S D; Hviid, L; Theander, T G; Høier-Madsen, M; Bayoumi, R A; Greenwood, B M.
In: Immunology, Vol. 79, No. 4, 1993, p. 653-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Anti-phospholipid antibodies in patients with Plasmodium falciparum malaria
AU - Jakobsen, P H
AU - Morris-Jones, S D
AU - Hviid, L
AU - Theander, T G
AU - Høier-Madsen, M
AU - Bayoumi, R A
AU - Greenwood, B M
N1 - Keywords: Adult; Antibodies, Antiphospholipid; Antibodies, Protozoan; Cardiolipins; Child; Enzyme-Linked Immunosorbent Assay; Gambia; Humans; Immunoglobulin G; Immunoglobulin M; Malaria, Falciparum; Phosphatidylcholines; Phosphatidylinositols; Sudan
PY - 1993
Y1 - 1993
N2 - Plasma levels of antibodies against phosphatidylinositol (PI), phosphatidylcholine (PC) and cardiolipin (CL) were measured by enzyme-linked immunosorbent assay (ELISA) in patients from malaria endemic area of Sudan and The Gambia. Some Sudanese adults produced IgM antibodies against all three types of phospholipids (PL) during an acute Plasmodium falciparum infection. The anti-PL antibody titre returned to preinfection levels in most of the donors 30 days after the disease episode. IgG titres against PI, PC and CL were low. In Gambian children with malaria, IgM antibody titres against PI and PC were significantly higher in those with severe malaria than in those with mild malaria. These results show that a proportion of malaria patients produce anti-PL antibodies during infection and that titres of these antibodies are associated with the severity of disease.
AB - Plasma levels of antibodies against phosphatidylinositol (PI), phosphatidylcholine (PC) and cardiolipin (CL) were measured by enzyme-linked immunosorbent assay (ELISA) in patients from malaria endemic area of Sudan and The Gambia. Some Sudanese adults produced IgM antibodies against all three types of phospholipids (PL) during an acute Plasmodium falciparum infection. The anti-PL antibody titre returned to preinfection levels in most of the donors 30 days after the disease episode. IgG titres against PI, PC and CL were low. In Gambian children with malaria, IgM antibody titres against PI and PC were significantly higher in those with severe malaria than in those with mild malaria. These results show that a proportion of malaria patients produce anti-PL antibodies during infection and that titres of these antibodies are associated with the severity of disease.
M3 - Journal article
C2 - 8406592
VL - 79
SP - 653
EP - 657
JO - Immunology
JF - Immunology
SN - 0019-2805
IS - 4
ER -
ID: 6748369