Antibody-dependent cellular inhibition is associated with reduced risk against febrile malaria in a longitudinal cohort study involving Ghanaian children
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Antibody-dependent cellular inhibition is associated with reduced risk against febrile malaria in a longitudinal cohort study involving Ghanaian children. / Tiendrebeogo, Regis W; Adu, Bright; Singh, Susheel K; Dziegiel, Morten H; Nébié, Issa; Sirima, Sodiomon B; Christiansen, Michael; Dodoo, Daniel; Theisen, Michael.
In: Open forum in Infectious Diseases, Vol. 2, No. 2, ofv044, 2015.Research output: Contribution to journal › Letter › Research › peer-review
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TY - JOUR
T1 - Antibody-dependent cellular inhibition is associated with reduced risk against febrile malaria in a longitudinal cohort study involving Ghanaian children
AU - Tiendrebeogo, Regis W
AU - Adu, Bright
AU - Singh, Susheel K
AU - Dziegiel, Morten H
AU - Nébié, Issa
AU - Sirima, Sodiomon B
AU - Christiansen, Michael
AU - Dodoo, Daniel
AU - Theisen, Michael
PY - 2015
Y1 - 2015
N2 - The antibody-dependent respiratory burst and opsonic phagocytosis assays have been associated with protection against malaria; however, other mechanisms may also be involved. The antibody-dependent cellular inhibition (ADCI) assay is yet to be correlated with protection in longitudinal cohort studies (LCS). We investigated the relationship between ADCI activity of immunoglobulin G before malaria season and risk of malaria in a LCS involving Ghanaian children. High ADCI activity was significantly associated with reduced risk against malaria. Findings here suggest a potential usefulness of the ADCI assay as a correlate of protection to guide malaria vaccine studies.
AB - The antibody-dependent respiratory burst and opsonic phagocytosis assays have been associated with protection against malaria; however, other mechanisms may also be involved. The antibody-dependent cellular inhibition (ADCI) assay is yet to be correlated with protection in longitudinal cohort studies (LCS). We investigated the relationship between ADCI activity of immunoglobulin G before malaria season and risk of malaria in a LCS involving Ghanaian children. High ADCI activity was significantly associated with reduced risk against malaria. Findings here suggest a potential usefulness of the ADCI assay as a correlate of protection to guide malaria vaccine studies.
U2 - 10.1093/ofid/ofv044
DO - 10.1093/ofid/ofv044
M3 - Letter
C2 - 26380342
VL - 2
JO - Open Forum Infectious Diseases
JF - Open Forum Infectious Diseases
SN - 2328-8957
IS - 2
M1 - ofv044
ER -
ID: 144288044