Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the Plasmodium falciparum erythrocyte membrane protein 1 antigen family varies between Groups A, B, and C

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the Plasmodium falciparum erythrocyte membrane protein 1 antigen family varies between Groups A, B, and C. / Olsen, Rebecca W; Ecklu-Mensah, Gertrude; Bengtsson, Anja; Ofori, Michael F; Kusi, Kwadwo A; Koram, Kwadwo A; Hviid, Lars; Adams, Yvonne; Jensen, Anja T R.

In: Infection and Immunity, Vol. 87, No. 10, e00224-19, 2019.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Olsen, RW, Ecklu-Mensah, G, Bengtsson, A, Ofori, MF, Kusi, KA, Koram, KA, Hviid, L, Adams, Y & Jensen, ATR 2019, 'Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the Plasmodium falciparum erythrocyte membrane protein 1 antigen family varies between Groups A, B, and C', Infection and Immunity, vol. 87, no. 10, e00224-19. https://doi.org/10.1128/IAI.00224-19

APA

Olsen, R. W., Ecklu-Mensah, G., Bengtsson, A., Ofori, M. F., Kusi, K. A., Koram, K. A., Hviid, L., Adams, Y., & Jensen, A. T. R. (2019). Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the Plasmodium falciparum erythrocyte membrane protein 1 antigen family varies between Groups A, B, and C. Infection and Immunity, 87(10), [e00224-19]. https://doi.org/10.1128/IAI.00224-19

Vancouver

Olsen RW, Ecklu-Mensah G, Bengtsson A, Ofori MF, Kusi KA, Koram KA et al. Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the Plasmodium falciparum erythrocyte membrane protein 1 antigen family varies between Groups A, B, and C. Infection and Immunity. 2019;87(10). e00224-19. https://doi.org/10.1128/IAI.00224-19

Author

Olsen, Rebecca W ; Ecklu-Mensah, Gertrude ; Bengtsson, Anja ; Ofori, Michael F ; Kusi, Kwadwo A ; Koram, Kwadwo A ; Hviid, Lars ; Adams, Yvonne ; Jensen, Anja T R. / Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the Plasmodium falciparum erythrocyte membrane protein 1 antigen family varies between Groups A, B, and C. In: Infection and Immunity. 2019 ; Vol. 87, No. 10.

Bibtex

@article{a55c9a8f85e648d28079fa128bf6191d,
title = "Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the Plasmodium falciparum erythrocyte membrane protein 1 antigen family varies between Groups A, B, and C",
abstract = "Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is an important malaria virulence factor. The protein family can be divided into clinically relevant subfamilies. ICAM-1-binding group A PfEMP1 proteins also bind endothelial protein C receptor and have been associated with cerebral malaria in children. IgG to these PfEMP1 proteins is acquired later in life than that to group A PfEMP1 not binding ICAM-1. The kinetics of acquisition of IgG to group B and C PfEMP1 proteins binding ICAM-1 is unclear and was studied here. Gene sequences encoding group B and C PfEMP1 with DBLβ domains known to bind ICAM-1 were used to identify additional binders. Levels of IgG specific for DBLβ domains from group A, B, and C PfEMP1 binding or not binding ICAM-1 were measured in plasma from Ghanaian children with or without malaria. Seven new ICAM-1-binding DBLβ domains from group B and C PfEMP1 were identified. Healthy children had higher levels of IgG specific for ICAM-1-binding DBLβ domains from group A than from groups B and C. However, the opposite pattern was found in children with malaria, particularly among young patients. Acquisition of IgG specific for DBLβ domains binding ICAM-1 differs between PfEMP1 groups.",
author = "Olsen, {Rebecca W} and Gertrude Ecklu-Mensah and Anja Bengtsson and Ofori, {Michael F} and Kusi, {Kwadwo A} and Koram, {Kwadwo A} and Lars Hviid and Yvonne Adams and Jensen, {Anja T R}",
year = "2019",
doi = "10.1128/IAI.00224-19",
language = "English",
volume = "87",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "10",

}

RIS

TY - JOUR

T1 - Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the Plasmodium falciparum erythrocyte membrane protein 1 antigen family varies between Groups A, B, and C

AU - Olsen, Rebecca W

AU - Ecklu-Mensah, Gertrude

AU - Bengtsson, Anja

AU - Ofori, Michael F

AU - Kusi, Kwadwo A

AU - Koram, Kwadwo A

AU - Hviid, Lars

AU - Adams, Yvonne

AU - Jensen, Anja T R

PY - 2019

Y1 - 2019

N2 - Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is an important malaria virulence factor. The protein family can be divided into clinically relevant subfamilies. ICAM-1-binding group A PfEMP1 proteins also bind endothelial protein C receptor and have been associated with cerebral malaria in children. IgG to these PfEMP1 proteins is acquired later in life than that to group A PfEMP1 not binding ICAM-1. The kinetics of acquisition of IgG to group B and C PfEMP1 proteins binding ICAM-1 is unclear and was studied here. Gene sequences encoding group B and C PfEMP1 with DBLβ domains known to bind ICAM-1 were used to identify additional binders. Levels of IgG specific for DBLβ domains from group A, B, and C PfEMP1 binding or not binding ICAM-1 were measured in plasma from Ghanaian children with or without malaria. Seven new ICAM-1-binding DBLβ domains from group B and C PfEMP1 were identified. Healthy children had higher levels of IgG specific for ICAM-1-binding DBLβ domains from group A than from groups B and C. However, the opposite pattern was found in children with malaria, particularly among young patients. Acquisition of IgG specific for DBLβ domains binding ICAM-1 differs between PfEMP1 groups.

AB - Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is an important malaria virulence factor. The protein family can be divided into clinically relevant subfamilies. ICAM-1-binding group A PfEMP1 proteins also bind endothelial protein C receptor and have been associated with cerebral malaria in children. IgG to these PfEMP1 proteins is acquired later in life than that to group A PfEMP1 not binding ICAM-1. The kinetics of acquisition of IgG to group B and C PfEMP1 proteins binding ICAM-1 is unclear and was studied here. Gene sequences encoding group B and C PfEMP1 with DBLβ domains known to bind ICAM-1 were used to identify additional binders. Levels of IgG specific for DBLβ domains from group A, B, and C PfEMP1 binding or not binding ICAM-1 were measured in plasma from Ghanaian children with or without malaria. Seven new ICAM-1-binding DBLβ domains from group B and C PfEMP1 were identified. Healthy children had higher levels of IgG specific for ICAM-1-binding DBLβ domains from group A than from groups B and C. However, the opposite pattern was found in children with malaria, particularly among young patients. Acquisition of IgG specific for DBLβ domains binding ICAM-1 differs between PfEMP1 groups.

U2 - 10.1128/IAI.00224-19

DO - 10.1128/IAI.00224-19

M3 - Journal article

C2 - 31308082

VL - 87

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 10

M1 - e00224-19

ER -

ID: 227737934