Acquisition of antibodies against endothelial protein C receptor-binding domains of Plasmodium falciparum erythrocyte membrane protein 1 in children with severe malaria

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Acquisition of antibodies against endothelial protein C receptor-binding domains of Plasmodium falciparum erythrocyte membrane protein 1 in children with severe malaria. / Rambhatla, Janavi S; Turner, Louise; Manning, Laurens; Laman, Moses; Davis, Timothy M E; Beeson, James G; Mueller, Ivo; Warrel, Jonathan; Theander, Thor G; Lavstsen, Thomas; Rogerson, Stephen J.

In: The Journal of Infectious Diseases, Vol. 219, No. 5, 2019, p. 808-818.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Rambhatla, JS, Turner, L, Manning, L, Laman, M, Davis, TME, Beeson, JG, Mueller, I, Warrel, J, Theander, TG, Lavstsen, T & Rogerson, SJ 2019, 'Acquisition of antibodies against endothelial protein C receptor-binding domains of Plasmodium falciparum erythrocyte membrane protein 1 in children with severe malaria', The Journal of Infectious Diseases, vol. 219, no. 5, pp. 808-818. https://doi.org/10.1093/infdis/jiy564

APA

Rambhatla, J. S., Turner, L., Manning, L., Laman, M., Davis, T. M. E., Beeson, J. G., Mueller, I., Warrel, J., Theander, T. G., Lavstsen, T., & Rogerson, S. J. (2019). Acquisition of antibodies against endothelial protein C receptor-binding domains of Plasmodium falciparum erythrocyte membrane protein 1 in children with severe malaria. The Journal of Infectious Diseases, 219(5), 808-818. https://doi.org/10.1093/infdis/jiy564

Vancouver

Rambhatla JS, Turner L, Manning L, Laman M, Davis TME, Beeson JG et al. Acquisition of antibodies against endothelial protein C receptor-binding domains of Plasmodium falciparum erythrocyte membrane protein 1 in children with severe malaria. The Journal of Infectious Diseases. 2019;219(5):808-818. https://doi.org/10.1093/infdis/jiy564

Author

Rambhatla, Janavi S ; Turner, Louise ; Manning, Laurens ; Laman, Moses ; Davis, Timothy M E ; Beeson, James G ; Mueller, Ivo ; Warrel, Jonathan ; Theander, Thor G ; Lavstsen, Thomas ; Rogerson, Stephen J. / Acquisition of antibodies against endothelial protein C receptor-binding domains of Plasmodium falciparum erythrocyte membrane protein 1 in children with severe malaria. In: The Journal of Infectious Diseases. 2019 ; Vol. 219, No. 5. pp. 808-818.

Bibtex

@article{f59e7441dadf46bdb45717173b78a32b,
title = "Acquisition of antibodies against endothelial protein C receptor-binding domains of Plasmodium falciparum erythrocyte membrane protein 1 in children with severe malaria",
abstract = "BACKGROUND: Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) mediates parasite sequestration in postcapillary venules in P. falciparum malaria. PfEMP1 types can be classified based on their cysteine-rich interdomain region (CIDR) domains. Antibodies to different PfEMP1 types develop gradually after repeated infections as children age, and antibodies to specific CIDR types may confer protection.METHODS: Levels of immunoglobulin G to 35 recombinant CIDR domains were measured by means of Luminex assay in acute-stage (baseline) and convalescent-stage plasma samples from Papua New Guinean children with severe or uncomplicated malaria and in healthy age-matched community controls.RESULTS: At baseline, antibody levels were similar across the 3 groups. After infection, children with severe malaria had higher antibody levels than those with uncomplicated malaria against the endothelial protein C receptor (EPCR) binding CIDRα1 domains, and this difference was largely confined to older children. Antibodies to EPCR-binding domains increased from presentation to follow-up in severe malaria, but not in uncomplicated malaria.CONCLUSIONS: The acquisition of antibodies against EPCR-binding CIDRα1 domains of PfEMP1 after a severe malaria episode suggest that EPCR-binding PfEMP1 may have a role in the pathogenesis of severe malaria in Papua New Guinea.",
author = "Rambhatla, {Janavi S} and Louise Turner and Laurens Manning and Moses Laman and Davis, {Timothy M E} and Beeson, {James G} and Ivo Mueller and Jonathan Warrel and Theander, {Thor G} and Thomas Lavstsen and Rogerson, {Stephen J}",
note = "{\textcopyright} The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",
year = "2019",
doi = "10.1093/infdis/jiy564",
language = "English",
volume = "219",
pages = "808--818",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "5",

}

RIS

TY - JOUR

T1 - Acquisition of antibodies against endothelial protein C receptor-binding domains of Plasmodium falciparum erythrocyte membrane protein 1 in children with severe malaria

AU - Rambhatla, Janavi S

AU - Turner, Louise

AU - Manning, Laurens

AU - Laman, Moses

AU - Davis, Timothy M E

AU - Beeson, James G

AU - Mueller, Ivo

AU - Warrel, Jonathan

AU - Theander, Thor G

AU - Lavstsen, Thomas

AU - Rogerson, Stephen J

N1 - © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

PY - 2019

Y1 - 2019

N2 - BACKGROUND: Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) mediates parasite sequestration in postcapillary venules in P. falciparum malaria. PfEMP1 types can be classified based on their cysteine-rich interdomain region (CIDR) domains. Antibodies to different PfEMP1 types develop gradually after repeated infections as children age, and antibodies to specific CIDR types may confer protection.METHODS: Levels of immunoglobulin G to 35 recombinant CIDR domains were measured by means of Luminex assay in acute-stage (baseline) and convalescent-stage plasma samples from Papua New Guinean children with severe or uncomplicated malaria and in healthy age-matched community controls.RESULTS: At baseline, antibody levels were similar across the 3 groups. After infection, children with severe malaria had higher antibody levels than those with uncomplicated malaria against the endothelial protein C receptor (EPCR) binding CIDRα1 domains, and this difference was largely confined to older children. Antibodies to EPCR-binding domains increased from presentation to follow-up in severe malaria, but not in uncomplicated malaria.CONCLUSIONS: The acquisition of antibodies against EPCR-binding CIDRα1 domains of PfEMP1 after a severe malaria episode suggest that EPCR-binding PfEMP1 may have a role in the pathogenesis of severe malaria in Papua New Guinea.

AB - BACKGROUND: Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) mediates parasite sequestration in postcapillary venules in P. falciparum malaria. PfEMP1 types can be classified based on their cysteine-rich interdomain region (CIDR) domains. Antibodies to different PfEMP1 types develop gradually after repeated infections as children age, and antibodies to specific CIDR types may confer protection.METHODS: Levels of immunoglobulin G to 35 recombinant CIDR domains were measured by means of Luminex assay in acute-stage (baseline) and convalescent-stage plasma samples from Papua New Guinean children with severe or uncomplicated malaria and in healthy age-matched community controls.RESULTS: At baseline, antibody levels were similar across the 3 groups. After infection, children with severe malaria had higher antibody levels than those with uncomplicated malaria against the endothelial protein C receptor (EPCR) binding CIDRα1 domains, and this difference was largely confined to older children. Antibodies to EPCR-binding domains increased from presentation to follow-up in severe malaria, but not in uncomplicated malaria.CONCLUSIONS: The acquisition of antibodies against EPCR-binding CIDRα1 domains of PfEMP1 after a severe malaria episode suggest that EPCR-binding PfEMP1 may have a role in the pathogenesis of severe malaria in Papua New Guinea.

U2 - 10.1093/infdis/jiy564

DO - 10.1093/infdis/jiy564

M3 - Journal article

C2 - 30365003

VL - 219

SP - 808

EP - 818

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 5

ER -

ID: 213826757