A threshold concentration of anti-merozoite antibodies is required for protection from clinical episodes of malaria
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A threshold concentration of anti-merozoite antibodies is required for protection from clinical episodes of malaria. / Murungi, Linda M; Kamuyu, Gathoni; Lowe, Brett; Bejon, Philip; Theisen, Michael; Kinyanjui, Samson M; Marsh, Kevin; Osier, Faith H A.
In: Vaccine, Vol. 31, No. 37, 20.08.2013, p. 3936-42.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A threshold concentration of anti-merozoite antibodies is required for protection from clinical episodes of malaria
AU - Murungi, Linda M
AU - Kamuyu, Gathoni
AU - Lowe, Brett
AU - Bejon, Philip
AU - Theisen, Michael
AU - Kinyanjui, Samson M
AU - Marsh, Kevin
AU - Osier, Faith H A
N1 - Copyright © 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.
PY - 2013/8/20
Y1 - 2013/8/20
N2 - Antibodies to selected Plasmodium falciparum merozoite antigens are often reported to be associated with protection from malaria in one epidemiological cohort, but not in another. Here, we sought to understand this paradox by exploring the hypothesis that a threshold concentration of antibodies is necessary for protection. We analyzed data from two independent cohorts along the Kenyan coast, one in which antibodies to AMA1, MSP-2 and MSP-3 were associated with protection from malaria (Chonyi) and another in which this association was not observed (Junju). We used a malaria reference reagent to standardize antibody measurements across both cohorts, and applied statistical methods to derive the threshold concentration of antibodies against each antigen that best correlated with a reduced risk of malaria (the protective threshold), in the Chonyi cohort. We then tested whether antibodies in Junju reached the protective threshold concentrations observed in the Chonyi cohort. Except for children under 3 years, the age-matched proportions of children achieving protective threshold concentrations of antibodies against AMA1 and MSP-2 were significantly lower in Junju compared to Chonyi (Fishers exact test, P
AB - Antibodies to selected Plasmodium falciparum merozoite antigens are often reported to be associated with protection from malaria in one epidemiological cohort, but not in another. Here, we sought to understand this paradox by exploring the hypothesis that a threshold concentration of antibodies is necessary for protection. We analyzed data from two independent cohorts along the Kenyan coast, one in which antibodies to AMA1, MSP-2 and MSP-3 were associated with protection from malaria (Chonyi) and another in which this association was not observed (Junju). We used a malaria reference reagent to standardize antibody measurements across both cohorts, and applied statistical methods to derive the threshold concentration of antibodies against each antigen that best correlated with a reduced risk of malaria (the protective threshold), in the Chonyi cohort. We then tested whether antibodies in Junju reached the protective threshold concentrations observed in the Chonyi cohort. Except for children under 3 years, the age-matched proportions of children achieving protective threshold concentrations of antibodies against AMA1 and MSP-2 were significantly lower in Junju compared to Chonyi (Fishers exact test, P
U2 - 10.1016/j.vaccine.2013.06.042
DO - 10.1016/j.vaccine.2013.06.042
M3 - Journal article
C2 - 23800539
VL - 31
SP - 3936
EP - 3942
JO - Vaccine
JF - Vaccine
SN - 0264-410X
IS - 37
ER -
ID: 80640705