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A randomized controlled Phase Ib trial of the malaria vaccine candidate GMZ2 in African children. / Bélard, Sabine; Issifou, Saadou; Hounkpatin, Aurore B; Schaumburg, Frieder; Ngoa, Ulysse Ateba; Esen, Meral; Fendel, Rolf; de Salazar, Pablo Martinez; Mürbeth, Raymund E; Milligan, Paul; Imbault, Nathalie; Imoukhuede, Egeruan Babatunde; Theisen, Michael; Jepsen, Søren; Noor, Ramadhani A; Okech, Brenda; Kremsner, Peter G; Mordmüller, Benjamin.
In:
P L o S One, Vol. 6, No. 7, 2011, p. e22525.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Bélard, S, Issifou, S, Hounkpatin, AB, Schaumburg, F, Ngoa, UA, Esen, M, Fendel, R, de Salazar, PM, Mürbeth, RE, Milligan, P, Imbault, N, Imoukhuede, EB
, Theisen, M, Jepsen, S, Noor, RA, Okech, B, Kremsner, PG & Mordmüller, B 2011, '
A randomized controlled Phase Ib trial of the malaria vaccine candidate GMZ2 in African children',
P L o S One, vol. 6, no. 7, pp. e22525.
https://doi.org/10.1371/journal.pone.0022525APA
Bélard, S., Issifou, S., Hounkpatin, A. B., Schaumburg, F., Ngoa, U. A., Esen, M., Fendel, R., de Salazar, P. M., Mürbeth, R. E., Milligan, P., Imbault, N., Imoukhuede, E. B.
, Theisen, M., Jepsen, S., Noor, R. A., Okech, B., Kremsner, P. G., & Mordmüller, B. (2011).
A randomized controlled Phase Ib trial of the malaria vaccine candidate GMZ2 in African children.
P L o S One,
6(7), e22525.
https://doi.org/10.1371/journal.pone.0022525Vancouver
Bélard S, Issifou S, Hounkpatin AB, Schaumburg F, Ngoa UA, Esen M et al.
A randomized controlled Phase Ib trial of the malaria vaccine candidate GMZ2 in African children.
P L o S One. 2011;6(7):e22525.
https://doi.org/10.1371/journal.pone.0022525Author
Bélard, Sabine ; Issifou, Saadou ; Hounkpatin, Aurore B ; Schaumburg, Frieder ; Ngoa, Ulysse Ateba ; Esen, Meral ; Fendel, Rolf ; de Salazar, Pablo Martinez ; Mürbeth, Raymund E ; Milligan, Paul ; Imbault, Nathalie ; Imoukhuede, Egeruan Babatunde ; Theisen, Michael ; Jepsen, Søren ; Noor, Ramadhani A ; Okech, Brenda ; Kremsner, Peter G ; Mordmüller, Benjamin. / A randomized controlled Phase Ib trial of the malaria vaccine candidate GMZ2 in African children. In: P L o S One. 2011 ; Vol. 6, No. 7. pp. e22525.
Bibtex
@article{7c3abba95ac942c0879e327f48b9b9de,
title = "A randomized controlled Phase Ib trial of the malaria vaccine candidate GMZ2 in African children",
abstract = "GMZ2 is a fusion protein of Plasmodium falciparum merozoite surface protein 3 (MSP3) and glutamate rich protein (GLURP) that mediates an immune response against the blood stage of the parasite. Two previous phase I clinical trials, one in na{\"i}ve European adults and one in malaria-exposed Gabonese adults showed that GMZ2 was well tolerated and immunogenic. Here, we present data on safety and immunogenicity of GMZ2 in one to five year old Gabonese children, a target population for future malaria vaccine efficacy trials.",
author = "Sabine B{\'e}lard and Saadou Issifou and Hounkpatin, {Aurore B} and Frieder Schaumburg and Ngoa, {Ulysse Ateba} and Meral Esen and Rolf Fendel and {de Salazar}, {Pablo Martinez} and M{\"u}rbeth, {Raymund E} and Paul Milligan and Nathalie Imbault and Imoukhuede, {Egeruan Babatunde} and Michael Theisen and S{\o}ren Jepsen and Noor, {Ramadhani A} and Brenda Okech and Kremsner, {Peter G} and Benjamin Mordm{\"u}ller",
year = "2011",
doi = "10.1371/journal.pone.0022525",
language = "English",
volume = "6",
pages = "e22525",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "7",
}
RIS
TY - JOUR
T1 - A randomized controlled Phase Ib trial of the malaria vaccine candidate GMZ2 in African children
AU - Bélard, Sabine
AU - Issifou, Saadou
AU - Hounkpatin, Aurore B
AU - Schaumburg, Frieder
AU - Ngoa, Ulysse Ateba
AU - Esen, Meral
AU - Fendel, Rolf
AU - de Salazar, Pablo Martinez
AU - Mürbeth, Raymund E
AU - Milligan, Paul
AU - Imbault, Nathalie
AU - Imoukhuede, Egeruan Babatunde
AU - Theisen, Michael
AU - Jepsen, Søren
AU - Noor, Ramadhani A
AU - Okech, Brenda
AU - Kremsner, Peter G
AU - Mordmüller, Benjamin
PY - 2011
Y1 - 2011
N2 - GMZ2 is a fusion protein of Plasmodium falciparum merozoite surface protein 3 (MSP3) and glutamate rich protein (GLURP) that mediates an immune response against the blood stage of the parasite. Two previous phase I clinical trials, one in naïve European adults and one in malaria-exposed Gabonese adults showed that GMZ2 was well tolerated and immunogenic. Here, we present data on safety and immunogenicity of GMZ2 in one to five year old Gabonese children, a target population for future malaria vaccine efficacy trials.
AB - GMZ2 is a fusion protein of Plasmodium falciparum merozoite surface protein 3 (MSP3) and glutamate rich protein (GLURP) that mediates an immune response against the blood stage of the parasite. Two previous phase I clinical trials, one in naïve European adults and one in malaria-exposed Gabonese adults showed that GMZ2 was well tolerated and immunogenic. Here, we present data on safety and immunogenicity of GMZ2 in one to five year old Gabonese children, a target population for future malaria vaccine efficacy trials.
U2 - 10.1371/journal.pone.0022525
DO - 10.1371/journal.pone.0022525
M3 - Journal article
C2 - 21829466
VL - 6
SP - e22525
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 7
ER -
