TARGETS team

  1. 2014
  2. Published

    Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria

    Zhang, Q., Siegel, T. N., Martins, R. M., Wang, F., Cao, J., Gao, Q., Cheng, X., Jiang, L., Hon, C., Scheidig-Benatar, C., Sakamoto, H., Turner, Louise, Jensen, Anja Ramstedt, Claes, A., Guizetti, J., Malmquist, N. A. & Scherf, A., 2014, In: Nature. 531, p. 431-435

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 2015
  4. Published

    PfEMP1 – a parasite protein family of key importance in Plasmodium falciparum malaria immunity and pathogenesis

    Hviid, Lars & Jensen, Anja Ramstedt, Apr 2015, Advances in Parasitology. Rollinson, D. & Stothard, J. R. (eds.). Vol. 88. p. 51-84 34 p. (Advances in Parasitology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  5. Published

    Mapping the binding site of a cross-reactive Plasmodium falciparum PfEMP1 monoclonal antibody inhibitory of ICAM-1 binding

    Lennartz, F., Bengtsson, A., Olsen, Rebecca Wendelboe, Joergensen, L., Brown, A., Remy, L., Man, P., Forest, E., Barfod, Lea Klingenberg, Adams, Yvonne, Higgins, M. K. & Jensen, Anja Ramstedt, 2015, In: Journal of immunology (Baltimore, Md. : 1950). 195, 7, p. 3273-83 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 2016
  7. Published

    Characterizing the impact of sustained sulfadoxine/pyrimethamine use upon the Plasmodium falciparum population in Malawi

    Ravenhall, M., Benavente, E. D., Mipando, M., Jensen, Anja Ramstedt, Sutherland, C. J., Roper, C., Sepúlveda, N., Kwiatkowski, D. P., Montgomery, J., Phiri, K. S., Terlouw, A., Craig, A., Campino, S., Ocholla, H. & Clark, T. G., 29 Nov 2016, In: Malaria Journal. 15, 11 p., 575.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2017
  9. Published

    Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria

    Lennartz, F., Adams, Y., Bengtsson, A., Olsen, R. W., Turner, L., Ndam, N. T., Ecklu-Mensah, G. D., Moussiliou, A., Ofori, M. F., Gamain, B., Lusingu, J. P., Petersen, J. E. V., Wang, C. W., Nunes-Silva, S., Jespersen, J. S., Lau, C. K. Y., Theander, T. G., Lavstsen, T., Hviid, L., Higgins, M. K. & 1 others, Jensen, Anja Ramstedt, 8 Mar 2017, In: Cell Host & Microbe. 21, 3, p. 403-414 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Parasites causing cerebral falciparum malaria bind multiple endothelial receptors and express EPCR and ICAM-1-binding PfEMP1

    Tuikue Ndam, N., Moussiliou, A., Lavstsen, Thomas, Kamaliddin, C., Jensen, Anja Ramstedt, Mama, A., Tahar, R., Wang, Christian William, Jespersen, Jakob Schmidt, Alao, J. M., Gamain, B., Theander, Thor Grundtvig & Deloron, P., 2017, In: The Journal of Infectious Diseases. 215, 12, p. 1918-1925 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. 2018
  12. Published

    Activated integrins identify functional antigen-specific CD8 T cells within minutes after antigen stimulation

    Dimitrov, S., Gouttefangeas, C., Besedovsky, L., Jensen, Anja Ramstedt, Chandran, P. A., Rusch, E., Businger, R., Schindler, M., Lange, T., Born, J. & Rammensee, H., 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 24, p. E5536-E5545

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Blood outgrowth endothelial cells (BOECs) as a novel tool for studying adhesion of Plasmodium falciparum-infected erythrocytes

    Ecklu-Mensah, G., Olsen, Rebecca Wendelboe, Bengtsson, A., Ofori, M. F., Hviid, Lars, Jensen, Anja Ramstedt & Adams, Yvonne, 2018, In: PLoS ONE. 13, 10, 12 p., e0204177.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    A vaccine targeted specifically to prevent cerebral malaria - is there hope?

    Hviid, Lars, Lavstsen, Thomas & Jensen, Anja Ramstedt, Jul 2018, In: Expert Review of Vaccines. 17, 7, p. 565-567 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

  15. Published

    Natural and vaccine-induced acquisition of cross-reactive IgG inhibiting ICAM-1-specific binding of a Plasmodium falciparum PfEMP1 subtype associated specifically with cerebral malaria

    Olsen, Rebecca Wendelboe, Ecklu-Mensah, G., Bengtsson, A., Ofori, M. F., Lusingu, J. P. A., Castberg, F. C., Hviid, Lars, Adams, Yvonne & Jensen, Anja Ramstedt, 2018, In: Infection and Immunity. 86, 4, 17 p., e00622-17.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Shed EBA-175 mediates red blood cell clustering that enhances malaria parasite growth and enables immune evasion

    Paing, M. M., Salinas, N. D., Adams, Yvonne, Oksman, A., Jensen, Anja Ramstedt, Goldberg, D. E. & Tolia, N. H., 2018, In: eLife. 7, 18 p., e43224.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    A specific PfEMP1 is expressed in P. falciparum sporozoites and plays a role in hepatocyte infection

    Zanghì, G., Vembar, S. S., Baumgarten, S., Ding, S., Guizetti, J., Bryant, J. M., Mattei, D., Jensen, A. T. R., Rénia, L., Goh, Y. S., Sauerwein, R., Hermsen, C. C., Franetich, J-F., Bordessoulles, M., Silvie, O., Soulard, V., Scatton, O., Chen, P., Mecheri, S., Mazier, D. & 1 others, Scherf, A., 2018, In: Cell Reports. 22, 11, p. 2951-2963 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. 2019
  19. Published

    Gαs-coupled receptor signaling and sleep regulate integrin activation of human antigen-specific T cells

    Dimitrov, S., Lange, T., Gouttefangeas, C., Jensen, Anja Ramstedt, Szczepanski, M., Lehnnolz, J., Soekadar, S., Rammensee, H., Born, J. & Besedovsky, L., 2019, In: The Journal of Experimental Medicine. 216, 3, p. 517-526 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the Plasmodium falciparum erythrocyte membrane protein 1 antigen family varies between Groups A, B, and C

    Olsen, Rebecca Wendelboe, Ecklu-Mensah, G., Bengtsson, A., Ofori, M. F., Kusi, K. A., Koram, K. A., Hviid, Lars, Adams, Yvonne & Jensen, Anja Ramstedt, 2019, In: Infection and Immunity. 87, 10, e00224-19.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Comprehensive analysis of Fc-mediated IgM binding to the Plasmodium falciparum erythrocyte membrane protein 1 family in three parasite clones

    Quintana Varon, Maria del Pilar, Ecklu-Mensah, G., Tcherniuk, S. O., Ditlev, S. B., Oleinikov, A. V., Hviid, Lars & Lopez-Perez, Mary, 2019, In: Scientific Reports. 9, 1, 11 p., 6050.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. 2020
  23. Published

    Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1-based vaccines to prevent it

    Jensen, Anja Ramstedt, Adams, Yvonne & Hviid, Lars, 2020, In: Immunological Reviews. 293, 1, p. 230-252

    Research output: Contribution to journalReviewResearchpeer-review

  24. Published

    In vitro selection for adhesion of Plasmodium falciparum-infected erythrocytes to ABO antigens does not affect PfEMP1 and RIFIN expression

    van der Puije, W., Wang, Christian William, Sudharson, S., Hempel, C., Olsen, Rebecca Wendelboe, Dalgaard, Nanna, Ofori, M. F., Hviid, Lars, Kurtzhals, Jørgen & Staalsø, Trine, 2020, In: Scientific Reports. 10, 1, p. 12871 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. 2021
  26. Published

    Plasmodium falciparum erythrocyte membrane protein 1 variants induce cell swelling and disrupt the blood-brain barrier in cerebral malaria

    Adams, Yvonne, Olsen, Rebecca Wendelboe, Bengtsson, A., Dalgaard, Nanna, Zdioruk, M., Satpathi, S., Behera, P. K., Sahu, P. K., Lawler, S. E., Qvortrup, Klaus, Wassmer, S. C. & Jensen, Anja Ramstedt, 2021, In: The Journal of Experimental Medicine. 218, 3, 16 p., e20201266.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Strain-Dependent Inhibition of Erythrocyte Invasion by Monoclonal Antibodies Against Plasmodium falciparum CyRPA

    Knudsen, Anne Schlitterlau, Björnsson, K. H., Bassi, Maria Rosaria, Walker, Melanie Rose, Kok, A., Cristinoi, B., Jensen, Anja Ramstedt & Barfod, Lea Klingenberg, 2021, In: Frontiers in Immunology. 12, 716305.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    IRDye800CW labeled uPAR-targeting peptide for fluorescence-guided glioblastoma surgery: Preclinical studies in orthotopic xenografts

    Kurbegovic, Sorel, Stræde, Karina, Sørensen, K. K., Leth, Julie Maja, Willemoe, G. L., Christensen, Anders, Adams, Yvonne, Jensen, Anja Ramstedt, von Buchwald, Christian, Skjøth-rasmussen, J., Ploug, Michael, Jensen, Knud Jørgen & Kjær, Andreas, 2021, In: Theranostics. 11, 15, p. 7159-7174 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    PfEMP1-specific immunoglobulin G reactivity among Beninese pregnant women with sickle cell trait

    Lopez-Perez, Mary, Viwami, F., Seidu, Zakaria, Jensen, Anja Ramstedt, Doritchamou, J., Ndam, N. T. & Hviid, Lars, 2021, In: Open Forum Infectious Diseases. 8, 12, ofab527.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Antigenic and immunogenic evaluation of permutations of soluble hepatitis C virus envelope protein E2 and E1 antigens

    Prentø, Jannick, Janitzek, C. M., Velázquez-Moctezuma, R., Goksøyr, L., Olsen, Rebecca Wendelboe, Fanalista, Margherita, Augestad, Elias Honerød, Thrane, Susan, Pihl, A. F., Gottwein, Judith Margarete, Sander, Adam F. & Bukh, Jens, 2021, In: PLoS ONE. 16, e0255336.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Integrin activation enables sensitive detection of functional CD4+ and CD8+ T cells: Application to characterize SARS-CoV-2 immunity

    Schöllhorn, A., Schuhmacher, J., Besedovsky, L., Fendel, R., Jensen, Anja Ramstedt, Stevanović, S., Lange, T., Rammensee, H., Born, J., Gouttefangeas, C. & Dimitrov, S., 2021, In: Frontiers in Immunology. 12, 626308.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. 2022
  33. Published

    3D organoid assay of the impact of infected erythrocyte adhesion on the blood-brain barrier

    Adams, Yvonne & Jensen, Anja Ramstedt, 2022, Malaria Immunology: Targeting the Surface of Infected Erythrocytes. Humana Press, Vol. 2470. p. 587-599 13 p. (Methods in molecular biology (Clifton, N.J.)).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  34. Published

    Cerebral malaria - modelling interactions at the blood-brain barrier in vitro

    Adams, Yvonne & Jensen, Anja Ramstedt, 2022, In: Disease models & mechanisms. 15, 7, dmm049410.

    Research output: Contribution to journalJournal articleResearchpeer-review