Naturally acquired antibodies to the glutamate-rich protein are associated with protection against Plasmodium falciparum malaria

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Naturally acquired antibodies to the glutamate-rich protein are associated with protection against Plasmodium falciparum malaria. / Dodoo, D; Theisen, M; Kurtzhals, J A; Akanmori, B D; Koram, K A; Jepsen, S; Nkrumah, F K; Theander, T G; Hviid, L.

In: Journal of Infectious Diseases, Vol. 181, No. 3, 2000, p. 1202-5.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Dodoo, D, Theisen, M, Kurtzhals, JA, Akanmori, BD, Koram, KA, Jepsen, S, Nkrumah, FK, Theander, TG & Hviid, L 2000, 'Naturally acquired antibodies to the glutamate-rich protein are associated with protection against Plasmodium falciparum malaria', Journal of Infectious Diseases, vol. 181, no. 3, pp. 1202-5. https://doi.org/10.1086/315341

APA

Dodoo, D., Theisen, M., Kurtzhals, J. A., Akanmori, B. D., Koram, K. A., Jepsen, S., Nkrumah, F. K., Theander, T. G., & Hviid, L. (2000). Naturally acquired antibodies to the glutamate-rich protein are associated with protection against Plasmodium falciparum malaria. Journal of Infectious Diseases, 181(3), 1202-5. https://doi.org/10.1086/315341

Vancouver

Dodoo D, Theisen M, Kurtzhals JA, Akanmori BD, Koram KA, Jepsen S et al. Naturally acquired antibodies to the glutamate-rich protein are associated with protection against Plasmodium falciparum malaria. Journal of Infectious Diseases. 2000;181(3):1202-5. https://doi.org/10.1086/315341

Author

Dodoo, D ; Theisen, M ; Kurtzhals, J A ; Akanmori, B D ; Koram, K A ; Jepsen, S ; Nkrumah, F K ; Theander, T G ; Hviid, L. / Naturally acquired antibodies to the glutamate-rich protein are associated with protection against Plasmodium falciparum malaria. In: Journal of Infectious Diseases. 2000 ; Vol. 181, No. 3. pp. 1202-5.

Bibtex

@article{b5ec74b0a03b11dd86a6000ea68e967b,
title = "Naturally acquired antibodies to the glutamate-rich protein are associated with protection against Plasmodium falciparum malaria",
abstract = "The development of effective malaria vaccines depends on the identification of targets of well-defined protective immune responses. Data and samples from a longitudinal study of a cohort of children from coastal Ghana were used to investigate the role of antibody responses to 3 regions of the Plasmodium falciparum glutamate-rich protein (GLURP). The data show that levels of the GLURP-specific IgG that occurs in the nonrepeat region of the antigen are significantly correlated with clinical protection from P. falciparum malaria, after correction for the confounding effect of age. Furthermore, levels of cytophilic antibodies were found to be of particular importance for protection, lending support to the hypothesis that antibody-dependent cellular inhibition is the important element in GLURP-specific protective immunity.",
author = "D Dodoo and M Theisen and Kurtzhals, {J A} and Akanmori, {B D} and Koram, {K A} and S Jepsen and Nkrumah, {F K} and Theander, {T G} and L Hviid",
note = "Keywords: Adolescent; Animals; Antibodies, Protozoan; Child; Child, Preschool; Female; Humans; Immunoglobulin G; Immunoglobulin M; Malaria, Falciparum; Male; Plasmodium falciparum; Protozoan Proteins; Recombinant Proteins",
year = "2000",
doi = "10.1086/315341",
language = "English",
volume = "181",
pages = "1202--5",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - Naturally acquired antibodies to the glutamate-rich protein are associated with protection against Plasmodium falciparum malaria

AU - Dodoo, D

AU - Theisen, M

AU - Kurtzhals, J A

AU - Akanmori, B D

AU - Koram, K A

AU - Jepsen, S

AU - Nkrumah, F K

AU - Theander, T G

AU - Hviid, L

N1 - Keywords: Adolescent; Animals; Antibodies, Protozoan; Child; Child, Preschool; Female; Humans; Immunoglobulin G; Immunoglobulin M; Malaria, Falciparum; Male; Plasmodium falciparum; Protozoan Proteins; Recombinant Proteins

PY - 2000

Y1 - 2000

N2 - The development of effective malaria vaccines depends on the identification of targets of well-defined protective immune responses. Data and samples from a longitudinal study of a cohort of children from coastal Ghana were used to investigate the role of antibody responses to 3 regions of the Plasmodium falciparum glutamate-rich protein (GLURP). The data show that levels of the GLURP-specific IgG that occurs in the nonrepeat region of the antigen are significantly correlated with clinical protection from P. falciparum malaria, after correction for the confounding effect of age. Furthermore, levels of cytophilic antibodies were found to be of particular importance for protection, lending support to the hypothesis that antibody-dependent cellular inhibition is the important element in GLURP-specific protective immunity.

AB - The development of effective malaria vaccines depends on the identification of targets of well-defined protective immune responses. Data and samples from a longitudinal study of a cohort of children from coastal Ghana were used to investigate the role of antibody responses to 3 regions of the Plasmodium falciparum glutamate-rich protein (GLURP). The data show that levels of the GLURP-specific IgG that occurs in the nonrepeat region of the antigen are significantly correlated with clinical protection from P. falciparum malaria, after correction for the confounding effect of age. Furthermore, levels of cytophilic antibodies were found to be of particular importance for protection, lending support to the hypothesis that antibody-dependent cellular inhibition is the important element in GLURP-specific protective immunity.

U2 - 10.1086/315341

DO - 10.1086/315341

M3 - Journal article

C2 - 10720556

VL - 181

SP - 1202

EP - 1205

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 3

ER -

ID: 6747409