Haptoglobin 1-1 is associated with susceptibility to severe Plasmodium falciparum malaria
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Haptoglobin 1-1 is associated with susceptibility to severe Plasmodium falciparum malaria. / Quaye, I K; Ekuban, F A; Goka, B Q; Adabayeri, V; Kurtzhals, J A; Gyan, B; Ankrah, N A; Hviid, L; Akanmori, B D.
In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 94, No. 2, 2000, p. 216-9.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Haptoglobin 1-1 is associated with susceptibility to severe Plasmodium falciparum malaria
AU - Quaye, I K
AU - Ekuban, F A
AU - Goka, B Q
AU - Adabayeri, V
AU - Kurtzhals, J A
AU - Gyan, B
AU - Ankrah, N A
AU - Hviid, L
AU - Akanmori, B D
N1 - Keywords: Child; Child, Preschool; Electrophoresis, Polyacrylamide Gel; Genetic Predisposition to Disease; Haptoglobins; Humans; Infant; Malaria, Falciparum; Phenotype
PY - 2000
Y1 - 2000
N2 - The haptoglobin (Hp) phenotypes were determined by polyacrylamide-gel electrophoresis in plasma samples obtained in 1997 from 113 Plasmodium falciparum malaria patients (aged 1-12 years) with strictly defined cerebral malaria, severe malarial anaemia, or uncomplicated malaria and 42 age-matched healthy controls from the same area (coastal Ghana). Hp1-1 was significantly more prevalent among the patients (43%) than among healthy controls (7.1%), whereas Hp2-1 and Hp2-2 were underrepresented among the patients (11% and 2%, respectively) compared to the control donors (33% and 14%, respectively). No significant difference in frequency of Hp0 was observed between patients and controls. Among the malaria patients, the Hp1-1 phenotype was significantly more prevalent among patients with the complications of cerebral malaria and severe anaemia compared to patients with uncomplicated disease, whereas the reverse was seen with respect to Hp2-1 and Hp2-2. Our data suggest that the Hp1-1 phenotype is associated with susceptibility to P. falciparum malaria in general, and to the development of severe disease in particular.
AB - The haptoglobin (Hp) phenotypes were determined by polyacrylamide-gel electrophoresis in plasma samples obtained in 1997 from 113 Plasmodium falciparum malaria patients (aged 1-12 years) with strictly defined cerebral malaria, severe malarial anaemia, or uncomplicated malaria and 42 age-matched healthy controls from the same area (coastal Ghana). Hp1-1 was significantly more prevalent among the patients (43%) than among healthy controls (7.1%), whereas Hp2-1 and Hp2-2 were underrepresented among the patients (11% and 2%, respectively) compared to the control donors (33% and 14%, respectively). No significant difference in frequency of Hp0 was observed between patients and controls. Among the malaria patients, the Hp1-1 phenotype was significantly more prevalent among patients with the complications of cerebral malaria and severe anaemia compared to patients with uncomplicated disease, whereas the reverse was seen with respect to Hp2-1 and Hp2-2. Our data suggest that the Hp1-1 phenotype is associated with susceptibility to P. falciparum malaria in general, and to the development of severe disease in particular.
U2 - 10.1016/S0035-9203%2800%2990281-5
DO - 10.1016/S0035-9203%2800%2990281-5
M3 - Journal article
C2 - 10897372
VL - 94
SP - 216
EP - 219
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
SN - 0035-9203
IS - 2
ER -
ID: 6747363