Antibodies against PfEMP1, RIFIN, MSP3 and GLURP are acquired during controlled Plasmodium falciparum malaria infections in naïve volunteers
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Antibodies against PfEMP1, RIFIN, MSP3 and GLURP are acquired during controlled Plasmodium falciparum malaria infections in naïve volunteers. / Turner, Louise; Wang, Christian W; Lavstsen, Thomas; Mwakalinga, Steven B; Sauerwein, Robert W; Hermsen, Cornelus C; Theander, Thor G.
In: P L o S One, Vol. 6, No. 12, 2011, p. e29025.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Antibodies against PfEMP1, RIFIN, MSP3 and GLURP are acquired during controlled Plasmodium falciparum malaria infections in naïve volunteers
AU - Turner, Louise
AU - Wang, Christian W
AU - Lavstsen, Thomas
AU - Mwakalinga, Steven B
AU - Sauerwein, Robert W
AU - Hermsen, Cornelus C
AU - Theander, Thor G
PY - 2011
Y1 - 2011
N2 - Antibodies to polymorphic antigens expressed during the parasites erythrocytic stages are important mediators of protective immunity against P. falciparum malaria. Therefore, polymorphic blood stage antigens like MSP3, EBA-175 and GLURP and variant surface antigens PfEMP1 and RIFIN are considered vaccine candidates. However, to what extent these antibodies to blood stage antigens are acquired during naive individuals' first infections has not been studied in depth. Using plasma samples collected from controlled experimental P. falciparum infections we show that antibodies against variant surface antigens, PfEMP1 and RIFIN as well as MSP3 and GLURP, are acquired during a single short low density P. falciparum infection in non-immune individuals including strain transcendent PfEMP1 immune responses. These data indicate that the immunogenicity of the variant surface antigens is similar to the less diverse merozoite antigens. The acquisition of a broad and strain transcendent repertoire of PfEMP1 antibodies may reflect a parasite strategy of expressing most or all PfEMP1 variants at liver release optimizing the likelihood of survival and establishment of chronic infections in the new host.
AB - Antibodies to polymorphic antigens expressed during the parasites erythrocytic stages are important mediators of protective immunity against P. falciparum malaria. Therefore, polymorphic blood stage antigens like MSP3, EBA-175 and GLURP and variant surface antigens PfEMP1 and RIFIN are considered vaccine candidates. However, to what extent these antibodies to blood stage antigens are acquired during naive individuals' first infections has not been studied in depth. Using plasma samples collected from controlled experimental P. falciparum infections we show that antibodies against variant surface antigens, PfEMP1 and RIFIN as well as MSP3 and GLURP, are acquired during a single short low density P. falciparum infection in non-immune individuals including strain transcendent PfEMP1 immune responses. These data indicate that the immunogenicity of the variant surface antigens is similar to the less diverse merozoite antigens. The acquisition of a broad and strain transcendent repertoire of PfEMP1 antibodies may reflect a parasite strategy of expressing most or all PfEMP1 variants at liver release optimizing the likelihood of survival and establishment of chronic infections in the new host.
KW - Animals
KW - Antibodies, Protozoan
KW - Antigens, Protozoan
KW - Human Experimentation
KW - Humans
KW - Immunization
KW - Immunoglobulin G
KW - Life Cycle Stages
KW - Liver
KW - Malaria, Falciparum
KW - Membrane Proteins
KW - Plasmodium falciparum
KW - Protein Structure, Tertiary
KW - Protozoan Proteins
U2 - 10.1371/journal.pone.0029025
DO - 10.1371/journal.pone.0029025
M3 - Journal article
C2 - 22174947
VL - 6
SP - e29025
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 12
ER -
ID: 38369812