Thomas Lavstsen

Thomas Lavstsen

Professor

Member of:

  • DISCOVERY team

ORCID: 0000-0002-3044-4249

Publication year:
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1 - 25 out of 85Page size: 25
  1. 2024
  2. Published

    A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture

    Andradi-Brown, C., Wichers-Misterek, J. S., von Thien, H., Höppner, Y. D., Scholz, J. A. M., Hansson, Helle Smedegaard, Hocke, Emma Filtenborg, Gilberger, T. W., Duffy, M. F., Lavstsen, Thomas, Baum, J., Otto, T. D., Cunnington, A. J. & Bachmann, A., 25 Jan 2024, In: eLife. 12, 38 p., RP87726.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. 2023
  4. Published

    Endothelial protein C receptor binding induces conformational changes to severe malaria-associated group A PfEMP1

    Raghavan, Sai Sundar Rajan, Turner, Louise, Jensen, R. W., Johansen, Nicolai Tidemand, Jensen, D. S., Gourdon, Pontus Emanuel, Zhang, J., Wang, Y., Theander, Thor Grundtvig, Wang, Kaituo & Lavstsen, Thomas, 2023, In: Structure. 31, 10, p. 1174-1183.e4

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. 2022
  6. Published

    Analysis of var gene transcript patterns by quantitative real-time PCR

    Bachmann, A. & Lavstsen, Thomas, 2022, Malaria Immunology: Targeting the Surface of Infected Erythrocytes. Humana Press, Vol. 2470. p. 149–171 23 p. (Methods in molecular biology (Clifton, N.J.)).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  7. Published

    Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1.4 broadly reacting with polymorphic malarial protein VAR2CSA

    Raghavan, Sai Sundar Rajan, Dagil, Robert, Lopez-Perez, Mary, Conrad, J., Bassi, Maria Rosaria, Quintana Varon, Maria del Pilar, Choudhary, Swati, Gustavsson, Tobias, Wang, Y., Gourdon, Pontus Emanuel, Ofori, M. F., Christensen, S. B., Minja, D. T. R., Schmiegelow, Christentze, Nielsen, Morten Agertoug, Barfod, Lea Klingenberg, Hviid, Lars, Salanti, Ali, Lavstsen, Thomas & Wang, Kaituo, 2022, In: PLoS Pathogens. 18, 11, e1010924.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Mapping the cord blood transcriptome of pregnancies affected by early maternal anemia to identify signatures of fetal programming

    Hatem, G., Hjort, Line, Asplund, O., Minja, D. T. R., Msemo, O. A., Møller, S. L., Lavstsen, Thomas, Grunnet, Louise Groth, Lusingu, J. P. A., Hansson, O., Christensen, Dirk Lund, Vaag, Allan, Artner, I., Theander, Thor Grundtvig, Groop, L., Schmiegelow, Christentze, Bygbjerg, Ib Christian & Prasad, R. B., 2022, In: The Journal of clinical endocrinology and metabolism. 107, 5, p. 1303–1316 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Seroprevalence of SARS-CoV-2 antibodies among children and adolescents recruited in a malariometric survey in north-eastern Tanzania July 2021

    Lyimo, E., Fougeroux, Cyrielle Elyette, Malabeja, A., Mbwana, J., Hayuma, P. M., Liheluka, E., Turner, Louise, Gesase, S., Lavstsen, Thomas, Lusingu, J. P. A., Minja, D. T. R. & Wang, Christian William, 2022, In: BMC Infectious Diseases. 22, 846.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Varia: a tool for prediction, analysis and visualisation of variable genes

    Mackenzie, G., Jensen, R. W., Lavstsen, Thomas & Otto, T. D., 2022, In: BMC Bioinformatics. 23, 13 p., 52.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. 2021
  12. Published

    Common virulence gene expression in adult first-time infected malaria patients and severe cases

    Wichers, J. S., Tonkin-Hill, G., Thye, T., Krumkamp, R., Kreuels, B., Strauss, J., von Thien, H., Scholz, J. A. M., Smedegaard Hansson, H., Weisel Jensen, R., Turner, L., Lorenz, F-R., Schöllhorn, A., Bruchhaus, I., Tannich, E., Fendel, R., D Otto, T., Lavstsen, T., Gilberger, T. W., Duffy, M. & 1 others, Bachmann, A., 2021, In: eLife. 10, e69040.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Complement C1s cleaves PfEMP1 at interdomain conserved sites inhibiting Plasmodium falciparum cytoadherence

    Azasi, Y., Low, L. M., Just, A. N., Raghavan, Sai Sundar Rajan, Wang, Christian William, Valenzuela-Leon, P., Alexandra Rowe, J., Smith, J. D., Lavstsen, Thomas, Turner, Louise, Calvo, E. & Miller, L. H., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 22, e2104166118.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding

    Wang, Kaituo, Dagil, Robert, Lavstsen, Thomas, Misra, S. K., Spliid, C. B., Wang, Y., Gustavsson, Tobias, Sandoval, D. R., Vidal-Calvo, E. E., Choudhary, Swati, Agerbæk, Mette Ørskov, Lindorff-Larsen, Kresten, Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Sharp, J. S., Clausen, Thomas Mandel, Gourdon, Pontus Emanuel & Salanti, Ali, 2021, In: Nature Communications. 12, 1, 10 p., 2956.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Sickle-trait hemoglobin reduces adhesion to both CD36 and EPCR by Plasmodium falciparum-infected erythrocytes

    Petersen, J. E. V., Saelens, J. W., Freedman, E., Turner, Louise, Lavstsen, Thomas, Fairhurst, R. M., Diakité, M. & Taylor, S. M., 2021, In: P L o S Pathogens. 17, 6, 18 p., e1009659.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Structure-guided design of a synthetic mimic of an endothelial protein C receptor-binding PfEMP1 protein

    Barber, N. M., Lau, C. K. Y., Turner, Louise, Watson, G., Thrane, Susan, Lusingu, J. P. A., Lavstsen, Thomas & Higgins, M. K., 2021, In: mSphere. 6, 1, 14 p., e01081-20.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. 2020
  18. Published

    Dynamics of PfEMP1 Antibody Profile From Birth to 12 Months of Age in Beninese Infants

    Moussiliou, A., Turner, Louise, Cottrell, G., Doritchamou, J., Gbédandé, K., Fievet, N., Luty, A. J. F., Massougbodji, A., Theander, Thor Grundtvig, Deloron, P., Lavstsen, Thomas & Tuikue Ndam, N., 2020, In: The Journal of Infectious Diseases. 221, 12, p. 2010-2017 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Gene expression profiling of malaria parasites reveals common virulence gene expression in adult first-time infected patients and severe cases

    Wichers, J. S., Tonkin-Hill, G., Thye, T., Krumkamp, R., Kreuels, B., Strauss, J., Thien, H. V., Scholz, J. A. M., Hansson, H. S., Jensen, R. W., Turner, L., Lorenz, F-R., Schöllhorn, A., Bruchhaus, I., Tannich, E., Fendel, R., Otto, T. D., Lavstsen, T., Gilberger, T-W., Duffy, M. F. & 1 others, Bachmann, A., 2020, bioRxiv.

    Research output: Working paper › Preprint › Research

  20. Published

    Immunization with virus-like particles conjugated to CIDRα1 domain of Plasmodium falciparum erythrocyte membrane protein 1 induces inhibitory antibodies

    Harmsen, C., Turner, Louise, Thrane, Susan, Sander, Adam F. , Theander, Thor Grundtvig & Lavstsen, Thomas, 2020, In: Malaria Journal. 19, 1, 11 p., 132.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season

    Andrade, C. M., Fleckenstein, H., Thomson-Luque, R., Doumbo, S., Lima, N. F., Anderson, C., Hibbert, J., Hopp, C. S., Tran, T. M., Li, S., Niangaly, M., Cisse, H., Doumtabe, D., Skinner, J., Sturdevant, D., Ricklefs, S., Virtaneva, K., Asghar, M., Homann, M. V., Turner, L. & 17 others, Martins, J., Allman, E. L., N’Dri, M. E., Winkler, V., Llinás, M., Lavazec, C., Martens, C., Färnert, A., Kayentao, K., Ongoiba, A., Lavstsen, Thomas, Osório, N. S., Otto, T. D., Recker, M., Traore, B., Crompton, P. D. & Portugal, S., 2020, In: Nature Medicine. 26, p. 1929–1940

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Longitudinal analysis of naturally acquired PfEMP1 CIDR domain variant antibodies identifies associations with malaria protection

    Obeng-Adjei, N., Larremore, D. B., Turner, Louise, Ongoiba, A., Li, S., Doumbo, S., Yazew, T. B., Kayentao, K., Miller, L. H., Traore, B., Pierce, S. K., Buckee, C. O., Lavstsen, Thomas, Crompton, P. D. & Tran, T. M., 2020, In: JCI Insight. 5, 12, 15 p., e137262.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. 2019
  24. Published

    Plasmodium falciparum-CD36 structure-function relationships defined by ortholog scanning mutagenesis

    Cabrera, A., Neculai, D., Tran, V., Lavstsen, Thomas, Turner, Louise & Kain, K. C., 2019, In: The Journal of Infectious Diseases. 219, 6, p. 945-954

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Acquisition of antibodies against endothelial protein C receptor-binding domains of Plasmodium falciparum erythrocyte membrane protein 1 in children with severe malaria

    Rambhatla, J. S., Turner, Louise, Manning, L., Laman, M., Davis, T. M. E., Beeson, J. G., Mueller, I., Warrel, J., Theander, Thor Grundtvig, Lavstsen, Thomas & Rogerson, S. J., 2019, In: The Journal of Infectious Diseases. 219, 5, p. 808-818 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Associations between IgG reactivity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens and Burkitt lymphoma in Ghana and Uganda case-control studies

    Derkach, A., Otim, I., Pfeiffer, R. M., Onabajo, O. O., Legason, I. D., Nabalende, H., Ogwang, M. D., Kerchan, P., Talisuna, A. O., Ayers, L. W., Reynolds, S. J., Nkrumah, F., Neequaye, J., Bhatia, K., Theander, Thor Grundtvig, Prokunina-Olsson, L., Turner, Louise, Goedert, J. J., Lavstsen, Thomas & Mbulaiteye, S. M., 2019, In: EBioMedicine. 39, p. 358-368 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Cerebral malaria is associated with differential cytoadherence to brain endothelial cells

    Storm, J., Jespersen, Jakob Schmidt, Seydel, K. B., Szestak, T., Mbewe, M., Chisala, N. V., Phula, P., Wang, Christian William, Taylor, T. E., Moxon, C. A., Lavstsen, Thomas & Craig, A. G., 2019, In: EMBO Molecular Medicine. 2019, 11, 15 p., e9164.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Controlled human malaria infection with Plasmodium falciparum demonstrates impact of naturally acquired immunity on virulence gene expression

    Bachmann, A., Bruske, E., Krumkamp, R., Turner, Louise, Wichers, J. S., Petter, M., Held, J., Duffy, M. F., Sim, B. K. L., Hoffman, S. L., Kremsner, P. G., Lell, B., Lavstsen, Thomas, Frank, M., Mordmüller, B. & Tannich, E., 2019, In: PLOS Pathogens. 15, 7, 24 p., e1007906.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Meta-analysis of Plasmodium falciparum var signatures contributing to severe malaria in African children and Indian adults

    Duffy, F., Bernabeu, M., Babar, P. H., Kessler, A., Wang, Christian William, Vaz, M., Chery, L., Mandala, W. L., Rogerson, S. J., Taylor, T. E., Seydel, K. B., Lavstsen, Thomas, Gomes, E., Kim, K., Lusingu, J., Rathod, P. K., Aitchison, J. D. & Smith, J. D., 2019, In: mBio. 10, 2, 16 p., e00217-19.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Modified MHC Class II-Associated Invariant Chain Induces Increased Antibody Responses against Plasmodium falciparum Antigens after Adenoviral Vaccination

    Fougeroux, Cyrielle Elyette, Turner, Louise, Bojesen, Anders Miki, Lavstsen, Thomas & Holst, Peter Johannes, 2019, In: Journal of Immunology. 202, 8, p. 2320-2331

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. 2018
  32. Published

    Antibodies to intercellular adhesion molecule 1-binding Plasmodium falciparum erythrocyte membrane protein 1-DBLβ are biomarkers of protective immunity to malaria in a cohort of young children from Papua New Guinea

    Tessema, S. K., Utama, D., Chesnokov, O., Hodder, A. N., Lin, C. S., Harrison, G. L. A., Jespersen, Jakob Schmidt, Petersen, Bent, Tavul, L., Siba, P., Kwiatkowski, D., Lavstsen, Thomas, Hansen, D. S., Oleinikov, A. V., Mueller, I. & Barry, A. E., 1 Aug 2018, In: Infection and Immunity. 86, 8, p. 1-14 14 p., e00485-17.

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 12224