Thomas Lavstsen
Professor
- 2024
- Published
A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture
Andradi-Brown, C., Wichers-Misterek, J. S., von Thien, H., Höppner, Y. D., Scholz, J. A. M., Hansson, Helle Smedegaard, Hocke, Emma Filtenborg, Gilberger, T. W., Duffy, M. F., Lavstsen, Thomas, Baum, J., Otto, T. D., Cunnington, A. J. & Bachmann, A., 25 Jan 2024, In: eLife. 12, 38 p., RP87726.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Endothelial protein C receptor binding induces conformational changes to severe malaria-associated group A PfEMP1
Raghavan, Sai Sundar Rajan, Turner, Louise, Jensen, R. W., Johansen, Nicolai Tidemand, Jensen, D. S., Gourdon, Pontus Emanuel, Zhang, J., Wang, Y., Theander, Thor Grundtvig, Wang, Kaituo & Lavstsen, Thomas, 2023, In: Structure. 31, 10, p. 1174-1183.e4Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Analysis of var gene transcript patterns by quantitative real-time PCR
Bachmann, A. & Lavstsen, Thomas, 2022, Malaria Immunology: Targeting the Surface of Infected Erythrocytes. Humana Press, Vol. 2470. p. 149–171 23 p. (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1.4 broadly reacting with polymorphic malarial protein VAR2CSA
Raghavan, Sai Sundar Rajan, Dagil, Robert, Lopez-Perez, Mary, Conrad, J., Bassi, Maria Rosaria, Quintana Varon, Maria del Pilar, Choudhary, Swati, Gustavsson, Tobias, Wang, Y., Gourdon, Pontus Emanuel, Ofori, M. F., Christensen, S. B., Minja, D. T. R., Schmiegelow, Christentze, Nielsen, Morten Agertoug, Barfod, Lea Klingenberg, Hviid, Lars, Salanti, Ali, Lavstsen, Thomas & Wang, Kaituo, 2022, In: PLoS Pathogens. 18, 11, e1010924.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mapping the cord blood transcriptome of pregnancies affected by early maternal anemia to identify signatures of fetal programming
Hatem, G., Hjort, Line, Asplund, O., Minja, D. T. R., Msemo, O. A., Møller, S. L., Lavstsen, Thomas, Grunnet, Louise Groth, Lusingu, J. P. A., Hansson, O., Christensen, Dirk Lund, Vaag, Allan, Artner, I., Theander, Thor Grundtvig, Groop, L., Schmiegelow, Christentze, Bygbjerg, Ib Christian & Prasad, R. B., 2022, In: The Journal of clinical endocrinology and metabolism. 107, 5, p. 1303–1316 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Seroprevalence of SARS-CoV-2 antibodies among children and adolescents recruited in a malariometric survey in north-eastern Tanzania July 2021
Lyimo, E., Fougeroux, Cyrielle Elyette, Malabeja, A., Mbwana, J., Hayuma, P. M., Liheluka, E., Turner, Louise, Gesase, S., Lavstsen, Thomas, Lusingu, J. P. A., Minja, D. T. R. & Wang, Christian William, 2022, In: BMC Infectious Diseases. 22, 846.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Varia: a tool for prediction, analysis and visualisation of variable genes
Mackenzie, G., Jensen, R. W., Lavstsen, Thomas & Otto, T. D., 2022, In: BMC Bioinformatics. 23, 13 p., 52.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Common virulence gene expression in adult first-time infected malaria patients and severe cases
Wichers, J. S., Tonkin-Hill, G., Thye, T., Krumkamp, R., Kreuels, B., Strauss, J., von Thien, H., Scholz, J. A. M., Smedegaard Hansson, H., Weisel Jensen, R., Turner, L., Lorenz, F-R., Schöllhorn, A., Bruchhaus, I., Tannich, E., Fendel, R., D Otto, T., Lavstsen, T., Gilberger, T. W., Duffy, M. & 1 others, , 2021, In: eLife. 10, e69040.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Complement C1s cleaves PfEMP1 at interdomain conserved sites inhibiting Plasmodium falciparum cytoadherence
Azasi, Y., Low, L. M., Just, A. N., Raghavan, Sai Sundar Rajan, Wang, Christian William, Valenzuela-Leon, P., Alexandra Rowe, J., Smith, J. D., Lavstsen, Thomas, Turner, Louise, Calvo, E. & Miller, L. H., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 22, e2104166118.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding
Wang, Kaituo, Dagil, Robert, Lavstsen, Thomas, Misra, S. K., Spliid, C. B., Wang, Y., Gustavsson, Tobias, Sandoval, D. R., Vidal-Calvo, E. E., Choudhary, Swati, Agerbæk, Mette Ørskov, Lindorff-Larsen, Kresten, Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Sharp, J. S., Clausen, Thomas Mandel, Gourdon, Pontus Emanuel & Salanti, Ali, 2021, In: Nature Communications. 12, 1, 10 p., 2956.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sickle-trait hemoglobin reduces adhesion to both CD36 and EPCR by Plasmodium falciparum-infected erythrocytes
Petersen, J. E. V., Saelens, J. W., Freedman, E., Turner, Louise, Lavstsen, Thomas, Fairhurst, R. M., Diakité, M. & Taylor, S. M., 2021, In: P L o S Pathogens. 17, 6, 18 p., e1009659.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-guided design of a synthetic mimic of an endothelial protein C receptor-binding PfEMP1 protein
Barber, N. M., Lau, C. K. Y., Turner, Louise, Watson, G., Thrane, Susan, Lusingu, J. P. A., Lavstsen, Thomas & Higgins, M. K., 2021, In: mSphere. 6, 1, 14 p., e01081-20.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Dynamics of PfEMP1 Antibody Profile From Birth to 12 Months of Age in Beninese Infants
Moussiliou, A., Turner, Louise, Cottrell, G., Doritchamou, J., Gbédandé, K., Fievet, N., Luty, A. J. F., Massougbodji, A., Theander, Thor Grundtvig, Deloron, P., Lavstsen, Thomas & Tuikue Ndam, N., 2020, In: The Journal of Infectious Diseases. 221, 12, p. 2010-2017 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gene expression profiling of malaria parasites reveals common virulence gene expression in adult first-time infected patients and severe cases
Wichers, J. S., Tonkin-Hill, G., Thye, T., Krumkamp, R., Kreuels, B., Strauss, J., Thien, H. V., Scholz, J. A. M., Hansson, H. S., Jensen, R. W., Turner, L., Lorenz, F-R., Schöllhorn, A., Bruchhaus, I., Tannich, E., Fendel, R., Otto, T. D., Lavstsen, T., Gilberger, T-W., Duffy, M. F. & 1 others, , 2020, bioRxiv.Research output: Working paper › Preprint › Research
- Published
Immunization with virus-like particles conjugated to CIDRα1 domain of Plasmodium falciparum erythrocyte membrane protein 1 induces inhibitory antibodies
Harmsen, C., Turner, Louise, Thrane, Susan, Sander, Adam F. , Theander, Thor Grundtvig & Lavstsen, Thomas, 2020, In: Malaria Journal. 19, 1, 11 p., 132.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season
Andrade, C. M., Fleckenstein, H., Thomson-Luque, R., Doumbo, S., Lima, N. F., Anderson, C., Hibbert, J., Hopp, C. S., Tran, T. M., Li, S., Niangaly, M., Cisse, H., Doumtabe, D., Skinner, J., Sturdevant, D., Ricklefs, S., Virtaneva, K., Asghar, M., Homann, M. V., Turner, L. & 17 others, , 2020, In: Nature Medicine. 26, p. 1929–1940Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Longitudinal analysis of naturally acquired PfEMP1 CIDR domain variant antibodies identifies associations with malaria protection
Obeng-Adjei, N., Larremore, D. B., Turner, Louise, Ongoiba, A., Li, S., Doumbo, S., Yazew, T. B., Kayentao, K., Miller, L. H., Traore, B., Pierce, S. K., Buckee, C. O., Lavstsen, Thomas, Crompton, P. D. & Tran, T. M., 2020, In: JCI Insight. 5, 12, 15 p., e137262.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Plasmodium falciparum-CD36 structure-function relationships defined by ortholog scanning mutagenesis
Cabrera, A., Neculai, D., Tran, V., Lavstsen, Thomas, Turner, Louise & Kain, K. C., 2019, In: The Journal of Infectious Diseases. 219, 6, p. 945-954Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Acquisition of antibodies against endothelial protein C receptor-binding domains of Plasmodium falciparum erythrocyte membrane protein 1 in children with severe malaria
Rambhatla, J. S., Turner, Louise, Manning, L., Laman, M., Davis, T. M. E., Beeson, J. G., Mueller, I., Warrel, J., Theander, Thor Grundtvig, Lavstsen, Thomas & Rogerson, S. J., 2019, In: The Journal of Infectious Diseases. 219, 5, p. 808-818 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Associations between IgG reactivity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens and Burkitt lymphoma in Ghana and Uganda case-control studies
Derkach, A., Otim, I., Pfeiffer, R. M., Onabajo, O. O., Legason, I. D., Nabalende, H., Ogwang, M. D., Kerchan, P., Talisuna, A. O., Ayers, L. W., Reynolds, S. J., Nkrumah, F., Neequaye, J., Bhatia, K., Theander, Thor Grundtvig, Prokunina-Olsson, L., Turner, Louise, Goedert, J. J., Lavstsen, Thomas & Mbulaiteye, S. M., 2019, In: EBioMedicine. 39, p. 358-368 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cerebral malaria is associated with differential cytoadherence to brain endothelial cells
Storm, J., Jespersen, Jakob Schmidt, Seydel, K. B., Szestak, T., Mbewe, M., Chisala, N. V., Phula, P., Wang, Christian William, Taylor, T. E., Moxon, C. A., Lavstsen, Thomas & Craig, A. G., 2019, In: EMBO Molecular Medicine. 2019, 11, 15 p., e9164.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Controlled human malaria infection with Plasmodium falciparum demonstrates impact of naturally acquired immunity on virulence gene expression
Bachmann, A., Bruske, E., Krumkamp, R., Turner, Louise, Wichers, J. S., Petter, M., Held, J., Duffy, M. F., Sim, B. K. L., Hoffman, S. L., Kremsner, P. G., Lell, B., Lavstsen, Thomas, Frank, M., Mordmüller, B. & Tannich, E., 2019, In: PLOS Pathogens. 15, 7, 24 p., e1007906.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Meta-analysis of Plasmodium falciparum var signatures contributing to severe malaria in African children and Indian adults
Duffy, F., Bernabeu, M., Babar, P. H., Kessler, A., Wang, Christian William, Vaz, M., Chery, L., Mandala, W. L., Rogerson, S. J., Taylor, T. E., Seydel, K. B., Lavstsen, Thomas, Gomes, E., Kim, K., Lusingu, J., Rathod, P. K., Aitchison, J. D. & Smith, J. D., 2019, In: mBio. 10, 2, 16 p., e00217-19.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Modified MHC Class II-Associated Invariant Chain Induces Increased Antibody Responses against Plasmodium falciparum Antigens after Adenoviral Vaccination
Fougeroux, Cyrielle Elyette, Turner, Louise, Bojesen, Anders Miki, Lavstsen, Thomas & Holst, Peter Johannes, 2019, In: Journal of Immunology. 202, 8, p. 2320-2331Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Antibodies to intercellular adhesion molecule 1-binding Plasmodium falciparum erythrocyte membrane protein 1-DBLβ are biomarkers of protective immunity to malaria in a cohort of young children from Papua New Guinea
Tessema, S. K., Utama, D., Chesnokov, O., Hodder, A. N., Lin, C. S., Harrison, G. L. A., Jespersen, Jakob Schmidt, Petersen, Bent, Tavul, L., Siba, P., Kwiatkowski, D., Lavstsen, Thomas, Hansen, D. S., Oleinikov, A. V., Mueller, I. & Barry, A. E., 1 Aug 2018, In: Infection and Immunity. 86, 8, p. 1-14 14 p., e00485-17.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A vaccine targeted specifically to prevent cerebral malaria - is there hope?
Hviid, Lars, Lavstsen, Thomas & Jensen, Anja Ramstedt, Jul 2018, In: Expert Review of Vaccines. 17, 7, p. 565-567 3 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Immunization with Recombinant Plasmodium falciparum Erythrocyte Membrane Protein 1 CIDRα1 Domains Induces Domain Subtype Inhibitory Antibodies
Turner, Louise, Theander, Thor Grundtvig & Lavstsen, Thomas, 2018, In: Infection and Immunity. 86, 11, 11 p., e00435-18.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors
Saito, F., Hirayasu, K., Satoh, T., Wang, Christian William, Lusingu, J., Arimori, T., Shida, K., Palacpac, N. M. Q., Itagaki, S., Iwanaga, S., Takashima, E., Tsuboi, T., Kohyama, M., Suenaga, T., Colonna, M., Takagi, J., Lavstsen, Thomas, Horii, T. & Arase, H., 7 Dec 2017, In: Nature. 552, 7683, p. 101-105 5 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
PLASMODIUM FALCIPARUM PARASITES THAT INFECT RETINOPATHY POSITIVE AND NEGATIVE CEREBRAL MALARIA CHILDREN HAVE SIMILAR TRANSCRIPT ABUNDANCE OF VAR GENES ASSOCIATED WITH SEVERE MALARIA
Shabani, E., Opoka, R. O., Hanisch, B., Tang, B., Bangirana, P., Lavstsen, Thomas & John, C. C., Nov 2017, In: American Journal of Tropical Medicine and Hygiene. 95, 5 suppl., p. 75-75Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
PROFILES OF PFEMP1-SPECIFIC IGG ANTIBODIES FROM BIRTH TO 12 MONTHS OF AGE IN BENINESE INFANTS
Moussiliou, A., Cottrell, G., Turner, Louise, Lavstsen, Thomas, Fievet, N., Massougbodji, A., Theander, Thor Grundtvig, Deloron, P. & Ndam, N., Nov 2017, In: American Journal of Tropical Medicine and Hygiene. 95, 5 Suppl. , p. 302-302Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Plasmodium falciparum causing febrile infections express EPCR- binding PfEMP1
Mkumbaye, S., Wang, Christian William, Jespersen, Jakob Schmidt, Petersen, J. E. V., Kavishe, R., Lusingu, J., Theander, Thor Grundtvig & Lavstsen, Thomas, Oct 2017, In: Tropical Medicine & International Health. 22, S1, p. 7-7 1S3.3.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria
Lennartz, F., Adams, Y., Bengtsson, A., Olsen, R. W., Turner, L., Ndam, N. T., Ecklu-Mensah, G. D., Moussiliou, A., Ofori, M. F., Gamain, B., Lusingu, J. P., Petersen, J. E. V., Wang, C. W., Nunes-Silva, S., Jespersen, J. S., Lau, C. K. Y., Theander, T. G., Lavstsen, T., Hviid, L., Higgins, M. K. & 1 others, , 8 Mar 2017, In: Cell Host & Microbe. 21, 3, p. 403-414 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cellulose filtration of blood from malaria patients for improving ex vivo growth of Plasmodium falciparum parasites
Mkumbaye, S. I., Minja, D. T. R., Jespersen, Jakob Schmidt, Alifrangis, Michael, Kavishe, R. A., Mwakalinga, S. B., Lusingu, J. P., Theander, Thor Grundtvig, Lavstsen, Thomas & Wang, Christian William, 10 Feb 2017, In: Malaria Journal. 16, 1, 8 p., 69.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Parasites causing cerebral falciparum malaria bind multiple endothelial receptors and express EPCR and ICAM-1-binding PfEMP1
Tuikue Ndam, N., Moussiliou, A., Lavstsen, Thomas, Kamaliddin, C., Jensen, Anja Ramstedt, Mama, A., Tahar, R., Wang, Christian William, Jespersen, Jakob Schmidt, Alao, J. M., Gamain, B., Theander, Thor Grundtvig & Deloron, P., 2017, In: The Journal of Infectious Diseases. 215, 12, p. 1918-1925 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Plasmodium falciparum EPCR-binding PfEMP1 expression increases with malaria disease severity and is elevated in retinopathy negative cerebral malaria
Shabani, E., Hanisch, B., Opoka, R. O., Lavstsen, Thomas & John, C. C., 2017, In: BMC Medicine. 15, 1, 14 p., 183.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Severity of Plasmodium falciparum infection is associated with transcript levels of var genes encoding endothelial protein C receptor-binding P. falciparum erythrocyte membrane protein 1
Mkumbaye, S. I., Wang, Christian William, Lyimo, E., Jespersen, Jakob Schmidt, Manjurano, A., Mosha, J., Kavishe, R. A., Mwakalinga, S. B., Minja, D. T. R., Lusingu, J. P., Theander, Thor Grundtvig & Lavstsen, Thomas, 2017, In: Infection and Immunity. 85, 4, 14 p., 4e00841-16.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Cytoadhesion to gC1qR through Plasmodium falciparum erythrocyte membrane protein 1 in severe malaria
Magallón-Tejada, A., Machevo, S., Cisteró, P., Lavstsen, T., Aide, P., Rubio, M., Jiménez, A., Turner, L., Valmaseda, A., Gupta, H., De Las Salas, B., Mandomando, I., Wang, C. W., Petersen, J. E. V., Muñoz, J., Gascón, J., Macete, E., Alonso, P. L., Chitnis, C. E., Bassat, Q. & 1 others, , 11 Nov 2016, In: PLOS Pathogens. 12, 11, 22 p., e1006011.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Plasma Ang2 and ADAM17 levels are elevated during clinical malaria; Ang2 level correlates with severity and expression of EPCR-binding PfEMP1
Petersen, J. E. V., Mkumbaye, S. I., Vaaben, A. V., Manjurano, A., Lyimo, E., Kavishe, R. A., Mwakalinga, S. B., Mosha, J., Minja, D. T. R., Lusingu, J. P. A., Theander, Thor Grundtvig, Lavstsen, Thomas & Wang, Christian William, 27 Oct 2016, In: Scientific Reports. 6, 9 p., 35950.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Breaking down brain barrier breaches in cerebral malaria
Petersen, J. E. V., Lavstsen, Thomas & Craig, A., 3 Oct 2016, In: Journal of Clinical Investigation. 126, 10, p. 3725-3727 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Plasmodium falciparum Plasmodium helical interspersed subtelomeric proteins contribute to cytoadherence and anchor P. falciparum erythrocyte membrane protein 1 to the host cell cytoskeleton
Oberli, A., Zurbrügg, L., Rusch, S., Brand, F., Butler, M. E., Day, J. L., Cutts, E. E., Lavstsen, Thomas, Vakonakis, I. & Beck, H., Oct 2016, In: Cellular Microbiology. 18, 10, p. 1415-1428 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The structural basis for CD36 binding by the malaria parasite
Hsieh, F., Turner, Louise, Bolla, J. R., Robinson, C. V., Lavstsen, Thomas & Higgins, M. K., 27 Sep 2016, In: Nature Communications. 7, 11 p., 12837.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The endothelial protein C receptor rs867186-GG genotype is associated with increased soluble EPCR and could mediate protection against severe malaria
Shabani, E., Opoka, R. O., Bangirana, P., Park, G. S., Vercellotti, G. M., Guan, W., Hodges, J. S., Lavstsen, Thomas & John, C. C., 3 Jun 2016, In: Scientific Reports. 6, 11 p., 27084.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Adhesion of Plasmodium falciparum infected erythrocytes in ex vivo perfused placental tissue: a novel model of placental malaria
Pehrson, Caroline, Mathiesen, Line, Heno, K. K., Salanti, Ali, dos Santos Marques Resende, M., Dzikowski, R., Damm, Peter, Hansson, S. R., King, C. L., Schneider, H., Wang, Christian William, Lavstsen, Thomas, Theander, Thor Grundtvig, Knudsen, Lisbeth E. & Nielsen, Morten Agertoug, 26 May 2016, In: Malaria Journal. 15, 12 p., 292.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of EPCR in the pathogenesis of severe malaria
Mosnier, L. O. & Lavstsen, Thomas, May 2016, In: Thrombosis Research. 141 , S2, p. S46-S49 4 p.Research output: Contribution to journal › Conference article › Research › peer-review
- Published
Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRα1 domains
Jespersen, Jakob Schmidt, Wang, Christian William, Mkumbaye, S. I., Minja, D. T., Petersen, Bent, Turner, Louise, Petersen, J. E., Lusingu, J. P., Theander, Thor Grundtvig & Lavstsen, Thomas, 2016, In: EMBO Molecular Medicine. 8, 8, p. 839-850 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria
Duffy, M. F., Noviyanti, R., Tsuboi, T., Feng, Z., Trianty, L., Sebayang, B. F., Takashima, E., Sumardy, F., Lampah, D. A., Turner, Louise, Lavstsen, Thomas, Fowkes, F. J. I., Siba, P., Rogerson, S. J., Theander, Thor Grundtvig, Marfurt, J., Price, R. N., Anstey, N. M., Brown, G. V. & Papenfuss, A. T., 2016, In: Malaria Journal. 15, 12 p., 258.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Protein C system defects inflicted by the malaria parasite protein PfEMP1 can be overcome by a soluble EPCR variant
Petersen, J. E. V., Bouwens, E. A. M., Tamayo, I., Turner, Louise, Wang, Christian William, Stins, M., Theander, Thor Grundtvig, Hermida, J., Mosnier, L. O. & Lavstsen, Thomas, Nov 2015, In: Thrombosis and Haemostasis. 114, 5, p. 1038-48 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
IgG antibodies to endothelial protein C receptor-binding Cysteine-rich interdomain region domains of Plasmodium falciparum erythrocyte membrane protein 1 are acquired early in life in individuals exposed to malaria
Turner, Louise, Lavstsen, Thomas, Mmbando, B. P., Wang, Christian William, Magistrado, P. A., Vestergaard, L. S., Ishengoma, D. S., Minja, D. T. R., Lusingu, J. P. & Theander, Thor Grundtvig, Aug 2015, In: Infection and Immunity. 83, 8, p. 3096-103 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural Conservation Despite Huge Sequence Diversity Allows EPCR Binding by the PfEMP1 Family Implicated in Severe Childhood Malaria
Lau, C. K. Y., Turner, Louise, Jespersen, Jakob Schmidt, Lowe, E. D., Petersen, Bent, Wang, Christian William, Petersen, J. E. V., Lusingu, J., Theander, Thor Grundtvig, Lavstsen, Thomas & Higgins, M. K., 14 Jan 2015, In: Cell Host & Microbe. 17, 1, p. 118-29 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Haplotypes of the endothelial protein C receptor (EPCR) gene are not associated with severe malaria in Tanzania
Hansson, Helle Smedegaard, Turner, Louise, Møller, L., Wang, Christian William, Minja, D., Gesase, S., Mmbando, B., Bygbjerg, Ib Christian, Theander, Thor Grundtvig, Lusingu, J. P. A., Alifrangis, Michael & Lavstsen, Thomas, 2015, In: Malaria Journal. 14, 9 p., 474.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
DNA secondary structures are associated with recombination in major Plasmodium falciparum variable surface antigen gene families
Sander, Adam F. , Lavstsen, Thomas, Rask, T. S., Lisby, Michael, Salanti, Ali, Fordyce, S. L., Jespersen, Jakob Schmidt, Carter, R., Deitsch, K. W., Theander, Thor Grundtvig, Pedersen, A. G. & Arnot, D. E., 2014, In: Nucleic Acids Research. 42, 4, p. 2270-81 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Malaria's deadly grip: cytoadhesion of Plasmodium falciparum-infected erythrocytes
Smith, J. D., Rowe, J. A., Higgins, M. K. & Lavstsen, Thomas, Dec 2013, In: Cellular Microbiology Online. 15, 12, p. 1976-83 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Early gametocytes of the malaria parasite Plasmodium falciparum specifically remodel the adhesive properties of infected erythrocyte surface
Tibúrcio, M., Silvestrini, F., Bertuccini, L., Sander, Adam F. , Turner, Louise, Lavstsen, Thomas & Alano, P., 1 Nov 2013, In: Cellular Microbiology Online. 15, 4, p. 647-659Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum
Jiang, L., Mu, J., Zhang, Q., Ni, T., Srinivasan, P., Rayavara, K., Yang, W., Turner, L., Lavstsen, T., Theander, T. G., Peng, W., Wei, G., Jing, Q., Wakabayashi, Y., Bansal, A., Luo, Y., Ribeiro, J. M. C., Scherf, A., Aravind, L., Zhu, J. & 2 others, , 11 Jul 2013, In: Nature. 499, 7457, p. 223-7 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Severe malaria is associated with parasite binding to endothelial protein C receptor
Turner, Louise, Lavstsen, Thomas, Berger, S. S., Wang, Christian William, Petersen, J. E. V., Avril, M., Brazier, A. J., Freeth, J., Jespersen, Jakob Schmidt, Nielsen, Morten Agertoug, Magistrado, P., Lusingu, J., Smith, J. D., Higgins, M. K. & Theander, Thor Grundtvig, 27 Jun 2013, In: Nature. 498, 7455, p. 502-5 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression of the domain cassette 8 Plasmodium falciparum erythrocyte membrane protein 1 is associated with cerebral malaria in Benin
Bertin, G. I., Lavstsen, Thomas, Guillonneau, F., Doritchamou, J., Wang, Christian William, Jespersen, Jakob Schmidt, Ezimegnon, S., Fievet, N., Alao, M. J., Lalya, F., Massougbodji, A., Ndam, N. T., Theander, Thor Grundtvig & Deloron, P., 2013, In: P L o S One. 8, 7, p. e68368Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Plasmodium falciparum Expressing Domain Cassette 5 Type PfEMP1 (DC5-PfEMP1) Bind PECAM1
Berger, S. S., Turner, Louise, Wang, Christian William, Petersen, J. E. V., Kraft, M., Lusingu, J. P. A., Mmbando, B., Marquard, A. M., Bengtsson, D. B. A. C., Hviid, Lars, Nielsen, Morten Agertoug, Theander, Thor Grundtvig & Lavstsen, Thomas, 2013, In: PloS one. 8, 7, p. e69117Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children
Lavstsen, Thomas, Turner, Louise, Saguti, F., Magistrado, P. A., Rask, T. S., Jespersen, Jakob Schmidt, Wang, Christian William, Berger, S. S., Baraka, V., Marquard, A. M., Seguin-Orlando, A., Willerslev, Eske, Gilbert, M Thomas P, Lusingu, J. P. A. & Theander, Thor Grundtvig, 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 26, p. E1791-E1800 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evidence for in vitro and in vivo expression of the conserved VAR3 (type 3) plasmodium falciparum erythrocyte membrane protein 1
Wang, Christian William, Lavstsen, Thomas, Bengtsson, D. C., Magistrado, P. A., Berger, S. S., Marquard, A. M., Alifrangis, Michael, Lusingu, J. P., Theander, Thor Grundtvig & Turner, Louise, 2012, In: Malaria Journal. 11, 1, p. 129Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression of a type B RIFIN in Plasmodium falciparum merozoites and gametes
Mwakalinga, S. B., Wang, Christian William, Bengtsson, D. C., Turner, Louise, Dinko, B., Lusingu, J. P., Arnot, D. E., Sutherland, C. J., Theander, Thor Grundtvig & Lavstsen, Thomas, 2012, In: Malaria Journal. 11, 1, p. 429Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Serological evidence of discrete spatial clusters of Plasmodium falciparum parasites
Bejon, P., Turner, Louise, Lavstsen, Thomas, Cham, G., Olotu, A., Drakeley, C. J., Lievens, M., Vekemans, J., Savarese, B., Lusingu, J., von Seidlein, L., Bull, P. C., Marsh, K. & Theander, Thor Grundtvig, 1 Jan 2011, In: P L o S One. 6, 6, p. e21711Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antibodies against PfEMP1, RIFIN, MSP3 and GLURP are acquired during controlled Plasmodium falciparum malaria infections in naïve volunteers
Turner, Louise, Wang, Christian William, Lavstsen, Thomas, Mwakalinga, S. B., Sauerwein, R. W., Hermsen, C. C. & Theander, Thor Grundtvig, 2011, In: P L o S One. 6, 12, p. e29025Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Positive selection of Plasmodium falciparum parasites with multiple var2csa-type PfEMP1 genes during the course of infection in pregnant women
Sander, A. F., Salanti, Ali, Lavstsen, Thomas, Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Leke, R. G. F., Lo, Y. Y., Bobbili, N., Arnot, D. E. & Taylor, D. W., 2011, In: Journal of Infectious Diseases. 203, 11, p. 1679-85 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Plasmodium falciparum erythrocyte membrane protein 1 diversity in seven genomes - divide and conquer
Rask, T. S., Hansen, D. A., Theander, Thor Grundtvig, Gorm Pedersen, A. & Lavstsen, Thomas, 2010, In: P L o S Computational Biology. 6, 9Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hierarchical, domain type-specific acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 in Tanzanian children
Cham, G. K. K., Turner, Louise, Kurtis, J. D., Mutabingwa, T., Fried, M., Jensen, Anja Ramstedt, Lavstsen, Thomas, Hviid, Lars, Duffy, P. E. & Theander, Thor Grundtvig, 2010, In: Infection and Immunity. 78, 11, p. 4653-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of a major rif transcript common to gametocytes and sporozoites of Plasmodium falciparum
Wang, Christian William, Mwakalinga, S. B., Sutherland, C. J., Schwank, S., Sharp, S., Hermsen, C. C., Sauerwein, R. W., Theander, Thor Grundtvig & Lavstsen, Thomas, 2010, In: Malaria Journal. 9, 1, p. 147Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Surface co-expression of two different PfEMP1 antigens on single Plasmodium falciparum-infected erythrocytes facilitates binding to ICAM1 and PECAM1
Joergensen, L., Bengtsson, D. C., Bengtsson, A., Ronander, E., Berger, S. S., Turner, Louise, Dalgaard, M. B., Cham, G. K. K., Victor, M. E., Lavstsen, Thomas, Theander, Thor Grundtvig, Arnot, D. E. & Jensen, Anja Ramstedt, 2010, In: PLoS Pathogens. 6, 9, p. e1001083Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
An upstream open reading frame controls translation of var2csa, a gene implicated in placental malaria
Amulic, B., Salanti, Ali, Lavstsen, Thomas, Nielsen, Morten Agertoug & Deitsch, K. W., 2009, In: PLoS Pathogens. 5, 1, p. e1000256Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human monoclonal IgG selection of Plasmodium falciparum for the expression of placental malaria-specific variant surface antigens
Soerli, J., Barfod, Lea Klingenberg, Lavstsen, Thomas, Bernasconi, N. L., Lanzavecchia, A. & Hviid, Lars, 2009, In: Parasite Immunology. 31, 6, p. 341-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multiple var2csa-type PfEMP1 genes located at different chromosomal loci occur in many Plasmodium falciparum isolates
Sander, Adam F. , Salanti, Ali, Lavstsen, Thomas, Nielsen, Morten Agertoug, Magistrado, P., Lusingu, J., Ndam, N. T. & Arnot, D. E., 2009, In: PLoS ONE. 4, 8, p. e6667Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Preferential transcription of conserved rif genes in two phenotypically distinct Plasmodium falciparum parasite lines
Wang, Christian William, Magistrado, P. A., Nielsen, Morten Agertoug, Theander, Thor Grundtvig & Lavstsen, Thomas, 2009, In: International Journal for Parasitology. 39, 6, p. 655-64 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sequential, ordered acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 domains
Cham, G. K. K., Turner, Louise, Lusingu, J., Vestergaard, L., Mmbando, B. P., Kurtis, J. D., Jensen, Anja Ramstedt, Salanti, Ali, Lavstsen, Thomas & Theander, Thor Grundtvig, 2009, In: Journal of Immunology. 183, 5, p. 3356-63 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer
Wang, Christian William, Hermsen, C. C., Sauerwein, R. W., Arnot, D. E., Theander, Thor Grundtvig & Lavstsen, Thomas, 2009, In: Parasitology International. 58, 4, p. 478-80 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Plasmodium falciparum transcriptome analysis reveals pregnancy malaria associated gene expression
Tuikue Ndam, N., Bischoff, E., Proux, C., Lavstsen, Thomas, Salanti, Ali, Guitard, J., Nielsen, Morten Agertoug, Coppée, J., Gaye, A., Theander, Thor Grundtvig, David, P. H. & Deloron, P., 2008, In: PLoS ONE. 3, 3, p. e1855Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
Changes in var gene mRNA levels during erythrocytic development in two phenotypically distinct Plasmodium falciparum parasites
Dahlbäck, M., Lavstsen, Thomas, Salanti, Ali, Hviid, Lars, Arnot, D. E., Theander, Thor Grundtvig & Nielsen, Morten Agertoug, 2007, In: Malaria Journal. 6, p. 78Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Immunoglobulin G antibody reactivity to a group A Plasmodium falciparum erythrocyte membrane protein 1 and protection from P. falciparum malaria
Magistrado, P. A., Lusingu, J., Vestergaard, L. S., Lemnge, M., Lavstsen, Thomas, Turner, Louise, Hviid, Lars, Jensen, Anja Ramstedt & Theander, Thor Grundtvig, 2007, In: Infection and Immunity. 75, 5, p. 2415-20 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Response to Duffy and Tham: Transcription and coregulation of multigene families in Plasmodium falciparum
Sharp, S., McRobert, L., Sutherland, C. & Lavstsen, Thomas, 2007, In: Trends in Parasitology. 23, 5, p. 186-187 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
Differential expression of var gene groups is associated with morbidity caused by Plasmodium falciparum infection in Tanzanian children
Rottmann, M., Lavstsen, Thomas, Mugasa, J. P., Kaestli, M., Jensen, Anja Ramstedt, Müller, D., Theander, Thor Grundtvig & Beck, H., 2006, In: Infection and Immunity. 74, 7, p. 3904-11 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Programmed transcription of the var gene family, but not of stevor, in Plasmodium falciparum gametocytes
Sharp, S., Lavstsen, Thomas, Fivelman, Q. L., Saeed, M., McRobert, L., Templeton, T. J., Jensen, Anja Ramstedt, Baker, D. A., Theander, Thor Grundtvig & Sutherland, C. J., 2006, In: Eukaryotic Cell. 5, 8, p. 1206-14 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
Expression of Plasmodium falciparum erythrocyte membrane protein 1 in experimentally infected humans
Lavstsen, Thomas, Magistrado, P., Hermsen, C. C., Salanti, Ali, Jensen, Anja Ramstedt, Sauerwein, R., Hviid, Lars, Theander, Thor Grundtvig & Staalsoe, T., 2005, In: Malaria Journal. 4, 1, p. 21Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes
Jensen, Anja Ramstedt, Magistrado, P., Sharp, S., Joergensen, L., Lavstsen, Thomas, Chiucchiuini, A., Salanti, Ali, Vestergaard, L. S., Lusingu, J. P., Hermsen, R., Sauerwein, R., Christensen, J., Nielsen, Morten Agertoug, Hviid, Lars, Sutherland, C., Staalsoe, T. & Theander, Thor Grundtvig, 2004, In: Journal of Experimental Medicine. 199, 9, p. 1179-90 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Compounds useful in the diagnosis and treatment of pregnancy-associated malaria
Theander, Thor Grundtvig, Salanti, Ali, Hviid, Lars, Staalsø, Trine, Jensen, Anja Ramstedt, Lavstsen, Thomas & Dahlbäck, M., 2004, Patent No. WO2004067559 A1, Priority date 27 Jan 2003, Priority No. WO2004067559 A1Research output: Patent
- Published
Evidence for the involvement of VAR2CSA in pregnancy-associated malaria
Salanti, Ali, Dahlbäck, M., Turner, Louise, Nielsen, Morten Agertoug, Barfod, Lea Klingenberg, Magistrado, P., Jensen, Anja Ramstedt, Lavstsen, Thomas, Ofori, M. F., Marsh, K., Hviid, Lars & Theander, Thor Grundtvig, 2004, In: Journal of Experimental Medicine. 200, 9, p. 1197-203 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
- Published
Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria
Salanti, Ali, Staalsoe, T., Lavstsen, Thomas, Jensen, Anja Ramstedt, Sowa, M. P. K., Arnot, D. E., Hviid, Lars & Theander, Thor Grundtvig, 2003, In: Molecular Microbiology. 49, 1, p. 179-91 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sub-grouping of Plasmodium falciparum 3D7 var genes based on sequence analysis of coding and non-coding regions
Lavstsen, Thomas, Salanti, Ali, Jensen, Anja Ramstedt, Arnot, D. E. & Theander, Thor Grundtvig, 2003, In: Malaria Journal. 2, p. 27Research output: Contribution to journal › Journal article › Research › peer-review
ID: 12224
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Plasmodium falciparum Plasmodium helical interspersed subtelomeric proteins contribute to cytoadherence and anchor P. falciparum erythrocyte membrane protein 1 to the host cell cytoskeleton
Research output: Contribution to journal › Journal article › Research › peer-review
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331
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Adhesion of Plasmodium falciparum infected erythrocytes in ex vivo perfused placental tissue: a novel model of placental malaria
Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria
Research output: Contribution to journal › Journal article › Research › peer-review
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