The antileishmanial activity of novel oxygenated chalcones and their mechanism of action

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The antileishmanial activity of novel oxygenated chalcones and their mechanism of action. / Zhai, L; Chen, M; Blom, J; Theander, T G; Christensen, S B; Kharazmi, A.

In: Journal of Antimicrobial Chemotherapy, Vol. 43, No. 6, 1999, p. 793-803.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Zhai, L, Chen, M, Blom, J, Theander, TG, Christensen, SB & Kharazmi, A 1999, 'The antileishmanial activity of novel oxygenated chalcones and their mechanism of action', Journal of Antimicrobial Chemotherapy, vol. 43, no. 6, pp. 793-803.

APA

Zhai, L., Chen, M., Blom, J., Theander, T. G., Christensen, S. B., & Kharazmi, A. (1999). The antileishmanial activity of novel oxygenated chalcones and their mechanism of action. Journal of Antimicrobial Chemotherapy, 43(6), 793-803.

Vancouver

Zhai L, Chen M, Blom J, Theander TG, Christensen SB, Kharazmi A. The antileishmanial activity of novel oxygenated chalcones and their mechanism of action. Journal of Antimicrobial Chemotherapy. 1999;43(6):793-803.

Author

Zhai, L ; Chen, M ; Blom, J ; Theander, T G ; Christensen, S B ; Kharazmi, A. / The antileishmanial activity of novel oxygenated chalcones and their mechanism of action. In: Journal of Antimicrobial Chemotherapy. 1999 ; Vol. 43, No. 6. pp. 793-803.

Bibtex

@article{2c1618d0a1ae11ddb6ae000ea68e967b,
title = "The antileishmanial activity of novel oxygenated chalcones and their mechanism of action",
abstract = "Our previous studies have shown that licochalcone A, an oxygenated chalcone, has antileishmanial and antimalarial activities, and alters the ultrastructure and function of the mitochondria of Leishmania spp. parasites. The present study was designed to investigate the antileishmanial activity and the mechanism of action of a group of new oxygenated chalcones. The tested oxygenated chalcones inhibited the in-vitro growth of Leishmania major promastigotes and Leishmania donovani amastigotes. Treatment of hamsters infected with L. donovani with intraperitoneal administration of two oxygenated chalcones resulted in a significant reduction of parasite load in the liver and the spleen compared with untreated control animals. The oxygenated chalcones also inhibited the respiration of the parasite and the activity of mitochondrial dehydrogenases. Electron microscopic studies illustrated that they altered the ultrastructure of the mitochondria of L. major promastigote. The data clearly indicate that this group of oxygenated chalcones has a strong antileishmanial activity and might be developed into a new antileishmanial drug. The antileishmanial activity of oxygenated chalcones might be the result of interference with function of the parasite mitochondria.",
author = "L Zhai and M Chen and J Blom and Theander, {T G} and Christensen, {S B} and A Kharazmi",
note = "Keywords: Animals; Antiprotozoal Agents; Chalcone; Cricetinae; Drug Evaluation, Preclinical; Humans; Leishmania donovani; Leishmania major; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; Macrophages; Male; Mesocricetus; Mitochondria; Oxidoreductases; Respiration",
year = "1999",
language = "English",
volume = "43",
pages = "793--803",
journal = "Journal of Antimicrobial Chemotherapy",
issn = "0305-7453",
publisher = "Oxford University Press",
number = "6",

}

RIS

TY - JOUR

T1 - The antileishmanial activity of novel oxygenated chalcones and their mechanism of action

AU - Zhai, L

AU - Chen, M

AU - Blom, J

AU - Theander, T G

AU - Christensen, S B

AU - Kharazmi, A

N1 - Keywords: Animals; Antiprotozoal Agents; Chalcone; Cricetinae; Drug Evaluation, Preclinical; Humans; Leishmania donovani; Leishmania major; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; Macrophages; Male; Mesocricetus; Mitochondria; Oxidoreductases; Respiration

PY - 1999

Y1 - 1999

N2 - Our previous studies have shown that licochalcone A, an oxygenated chalcone, has antileishmanial and antimalarial activities, and alters the ultrastructure and function of the mitochondria of Leishmania spp. parasites. The present study was designed to investigate the antileishmanial activity and the mechanism of action of a group of new oxygenated chalcones. The tested oxygenated chalcones inhibited the in-vitro growth of Leishmania major promastigotes and Leishmania donovani amastigotes. Treatment of hamsters infected with L. donovani with intraperitoneal administration of two oxygenated chalcones resulted in a significant reduction of parasite load in the liver and the spleen compared with untreated control animals. The oxygenated chalcones also inhibited the respiration of the parasite and the activity of mitochondrial dehydrogenases. Electron microscopic studies illustrated that they altered the ultrastructure of the mitochondria of L. major promastigote. The data clearly indicate that this group of oxygenated chalcones has a strong antileishmanial activity and might be developed into a new antileishmanial drug. The antileishmanial activity of oxygenated chalcones might be the result of interference with function of the parasite mitochondria.

AB - Our previous studies have shown that licochalcone A, an oxygenated chalcone, has antileishmanial and antimalarial activities, and alters the ultrastructure and function of the mitochondria of Leishmania spp. parasites. The present study was designed to investigate the antileishmanial activity and the mechanism of action of a group of new oxygenated chalcones. The tested oxygenated chalcones inhibited the in-vitro growth of Leishmania major promastigotes and Leishmania donovani amastigotes. Treatment of hamsters infected with L. donovani with intraperitoneal administration of two oxygenated chalcones resulted in a significant reduction of parasite load in the liver and the spleen compared with untreated control animals. The oxygenated chalcones also inhibited the respiration of the parasite and the activity of mitochondrial dehydrogenases. Electron microscopic studies illustrated that they altered the ultrastructure of the mitochondria of L. major promastigote. The data clearly indicate that this group of oxygenated chalcones has a strong antileishmanial activity and might be developed into a new antileishmanial drug. The antileishmanial activity of oxygenated chalcones might be the result of interference with function of the parasite mitochondria.

M3 - Journal article

C2 - 10404318

VL - 43

SP - 793

EP - 803

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

SN - 0305-7453

IS - 6

ER -

ID: 7695364