Seasonal changes in the Plasmodium falciparum population in individuals and their relationship to clinical malaria: a longitudinal study in a Sudanese village
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Seasonal changes in the Plasmodium falciparum population in individuals and their relationship to clinical malaria: a longitudinal study in a Sudanese village. / Roper, C; Richardson, W; Elhassan, I M; Giha, H; Hviid, L; Satti, G M; Theander, T G; Arnot, D E.
In: Parasitology, Vol. 116 ( Pt 6), 1998, p. 501-10.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Seasonal changes in the Plasmodium falciparum population in individuals and their relationship to clinical malaria: a longitudinal study in a Sudanese village
AU - Roper, C
AU - Richardson, W
AU - Elhassan, I M
AU - Giha, H
AU - Hviid, L
AU - Satti, G M
AU - Theander, T G
AU - Arnot, D E
N1 - Keywords: Adolescent; Adult; Animals; Child; Cohort Studies; Genotype; Humans; Longitudinal Studies; Malaria, Falciparum; Morbidity; Plasmodium falciparum; Polymerase Chain Reaction; Polymorphism, Genetic; Seasons; Sudan
PY - 1998
Y1 - 1998
N2 - Residents of Daraweesh village in Sudan were monitored for Plasmodium falciparum infection and malaria morbidity in 3 malaria seasons from 1993 to 1996. Malaria parasites were detected microscopically and by polymerase chain reaction (PCR) in a series of cross-sectional surveys. PCR revealed submicroscopical infections during the dry season, particularly among individuals who had recovered from a malaria episode following successful drug treatment. Clinical and subclinical infections were contrasted by assaying for allelic polymorphism at 2 gene loci, MSP-1 and GLURP and 2 hypotheses examined with reference to these data: that clinical malaria is associated with infection with novel parasite genotypes not previously detected in that host, or alternatively, that clinical malaria episodes are associated with an increased number of clones in an infection. We detected more mixed infections among clinical isolates, but people carrying parasites during the dry season were not found to have an increased risk of disease in the following malaria season. There was a clear association of disease with the appearance of novel parasite genotypes.
AB - Residents of Daraweesh village in Sudan were monitored for Plasmodium falciparum infection and malaria morbidity in 3 malaria seasons from 1993 to 1996. Malaria parasites were detected microscopically and by polymerase chain reaction (PCR) in a series of cross-sectional surveys. PCR revealed submicroscopical infections during the dry season, particularly among individuals who had recovered from a malaria episode following successful drug treatment. Clinical and subclinical infections were contrasted by assaying for allelic polymorphism at 2 gene loci, MSP-1 and GLURP and 2 hypotheses examined with reference to these data: that clinical malaria is associated with infection with novel parasite genotypes not previously detected in that host, or alternatively, that clinical malaria episodes are associated with an increased number of clones in an infection. We detected more mixed infections among clinical isolates, but people carrying parasites during the dry season were not found to have an increased risk of disease in the following malaria season. There was a clear association of disease with the appearance of novel parasite genotypes.
U2 - 10.1017/S0031182098002650
DO - 10.1017/S0031182098002650
M3 - Journal article
C2 - 9651932
VL - 116 ( Pt 6)
SP - 501
EP - 510
JO - Parasitology
JF - Parasitology
SN - 0031-1820
ER -
ID: 6748066