Seasonal changes in cell mediated immune responses to soluble Plasmodium falciparum antigens in children with haemoglobin AA and haemoglobin AS
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Seasonal changes in cell mediated immune responses to soluble Plasmodium falciparum antigens in children with haemoglobin AA and haemoglobin AS. / Abu-Zeid, Y A; Abdulhadi, N H; Theander, T G; Hviid, L; Saeed, B O; Jepsen, S; Jensen, J B; Bayoumi, R A.
In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 86, No. 1, 1992, p. 20-2.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Seasonal changes in cell mediated immune responses to soluble Plasmodium falciparum antigens in children with haemoglobin AA and haemoglobin AS
AU - Abu-Zeid, Y A
AU - Abdulhadi, N H
AU - Theander, T G
AU - Hviid, L
AU - Saeed, B O
AU - Jepsen, S
AU - Jensen, J B
AU - Bayoumi, R A
N1 - Keywords: Adolescent; Animals; Antigens, Protozoan; Child; Child, Preschool; Hemoglobin A; Hemoglobin, Sickle; Humans; Immunity, Cellular; Leukocyte Count; Longitudinal Studies; Mitosis; Monocytes; Plasmodium falciparum; Seasons
PY - 1992
Y1 - 1992
N2 - In this longitudinal study peripheral blood mononuclear cells (PBMC) were obtained before and during the malaria season from healthy HbAA and HbAS children. Cells were compared for proliferation in response to stimulation by soluble Plasmodium falciparum antigens (SPAg) or purified derivative of tuberculin (PPD). The lymphoproliferative responses to SPAg of the paired PBMC samples showed 2 distinct seasonal changes in relation to the haemoglobin phenotype. In HbAA children, the lymphoproliferative responses to SPAg were suppressed during the malaria season. In contrast, they were enhanced in HbAS children during the malaria season. No distinct seasonal change in the response to PPD was found in relation to the haemoglobin phenotype. The study points to the role of the sickle cell trait in modulating the cellular immune responses to falciparum malaria.
AB - In this longitudinal study peripheral blood mononuclear cells (PBMC) were obtained before and during the malaria season from healthy HbAA and HbAS children. Cells were compared for proliferation in response to stimulation by soluble Plasmodium falciparum antigens (SPAg) or purified derivative of tuberculin (PPD). The lymphoproliferative responses to SPAg of the paired PBMC samples showed 2 distinct seasonal changes in relation to the haemoglobin phenotype. In HbAA children, the lymphoproliferative responses to SPAg were suppressed during the malaria season. In contrast, they were enhanced in HbAS children during the malaria season. No distinct seasonal change in the response to PPD was found in relation to the haemoglobin phenotype. The study points to the role of the sickle cell trait in modulating the cellular immune responses to falciparum malaria.
M3 - Journal article
C2 - 1566293
VL - 86
SP - 20
EP - 22
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
SN - 0035-9203
IS - 1
ER -
ID: 6748479