Placental malaria is associated with higher LILRB2 expression in monocyte subsets and lower anti-malarial IgG antibodies during infancy

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Placental malaria is associated with higher LILRB2 expression in monocyte subsets and lower anti-malarial IgG antibodies during infancy. / Dechavanne, Celia; Nouatin, Odilon; Adamou, Rafiou; Edslev, Sofie; Hansen, Anita; Meurisse, Florian; Sadissou, Ibrahim; Gbaguidi, Erasme; Milet, Jacqueline; Cottrell, Gilles; Gineau, Laure; Sabbagh, Audrey; Massougbodji, Achille; Moutairou, Kabirou; Donadi, Eduardo A; Carosella, Edgardo D; Moreau, Philippe; Remarque, Ed; Theisen, Michael; Rouas-Freiss, Nathalie; Garcia, André; Favier, Benoit; Courtin, David.

In: Frontiers in Immunology, Vol. 13, 2022, p. 909831.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Dechavanne, C, Nouatin, O, Adamou, R, Edslev, S, Hansen, A, Meurisse, F, Sadissou, I, Gbaguidi, E, Milet, J, Cottrell, G, Gineau, L, Sabbagh, A, Massougbodji, A, Moutairou, K, Donadi, EA, Carosella, ED, Moreau, P, Remarque, E, Theisen, M, Rouas-Freiss, N, Garcia, A, Favier, B & Courtin, D 2022, 'Placental malaria is associated with higher LILRB2 expression in monocyte subsets and lower anti-malarial IgG antibodies during infancy', Frontiers in Immunology, vol. 13, pp. 909831. https://doi.org/10.3389/fimmu.2022.909831

APA

Dechavanne, C., Nouatin, O., Adamou, R., Edslev, S., Hansen, A., Meurisse, F., Sadissou, I., Gbaguidi, E., Milet, J., Cottrell, G., Gineau, L., Sabbagh, A., Massougbodji, A., Moutairou, K., Donadi, E. A., Carosella, E. D., Moreau, P., Remarque, E., Theisen, M., ... Courtin, D. (2022). Placental malaria is associated with higher LILRB2 expression in monocyte subsets and lower anti-malarial IgG antibodies during infancy. Frontiers in Immunology, 13, 909831. https://doi.org/10.3389/fimmu.2022.909831

Vancouver

Dechavanne C, Nouatin O, Adamou R, Edslev S, Hansen A, Meurisse F et al. Placental malaria is associated with higher LILRB2 expression in monocyte subsets and lower anti-malarial IgG antibodies during infancy. Frontiers in Immunology. 2022;13:909831. https://doi.org/10.3389/fimmu.2022.909831

Author

Dechavanne, Celia ; Nouatin, Odilon ; Adamou, Rafiou ; Edslev, Sofie ; Hansen, Anita ; Meurisse, Florian ; Sadissou, Ibrahim ; Gbaguidi, Erasme ; Milet, Jacqueline ; Cottrell, Gilles ; Gineau, Laure ; Sabbagh, Audrey ; Massougbodji, Achille ; Moutairou, Kabirou ; Donadi, Eduardo A ; Carosella, Edgardo D ; Moreau, Philippe ; Remarque, Ed ; Theisen, Michael ; Rouas-Freiss, Nathalie ; Garcia, André ; Favier, Benoit ; Courtin, David. / Placental malaria is associated with higher LILRB2 expression in monocyte subsets and lower anti-malarial IgG antibodies during infancy. In: Frontiers in Immunology. 2022 ; Vol. 13. pp. 909831.

Bibtex

@article{4c94defaed644eb188e8ea7333607475,
title = "Placental malaria is associated with higher LILRB2 expression in monocyte subsets and lower anti-malarial IgG antibodies during infancy",
abstract = "Background: Placental malaria (PM) is associated with a higher susceptibility of infants to Plasmodium falciparum (Pf) malaria. A hypothesis of immune tolerance has been suggested but no clear explanation has been provided so far. Our goal was to investigate the involvement of inhibitory receptors LILRB1 and LILRB2, known to drive immune evasion upon ligation with pathogen and/or host ligands, in PM-induced immune tolerance.Method: Infants of women with or without PM were enrolled in Allada, southern Benin, and followed-up for 24 months. Antibodies with specificity for five blood stage parasite antigens were quantified by ELISA, and the frequency of immune cell subsets was quantified by flow cytometry. LILRB1 or LILRB2 expression was assessed on cells collected at 18 and 24 months of age.Findings: Infants born to women with PM had a higher risk of developing symptomatic malaria than those born to women without PM (IRR=1.53, p=0.040), and such infants displayed a lower frequency of non-classical monocytes (OR=0.74, p=0.01) that overexpressed LILRB2 (OR=1.36, p=0.002). Moreover, infants born to women with PM had lower levels of cytophilic IgG and higher levels of IL-10 during active infection.Interpretation: Modulation of IgG and IL-10 levels could impair monocyte functions (opsonisation/phagocytosis) in infants born to women with PM, possibly contributing to their higher susceptibility to malaria. The long-lasting effect of PM on infants' monocytes was notable, raising questions about the capacity of ligands such as Rifins or HLA-I molecules to bind to LILRB1 and LILRB2 and to modulate immune responses, and about the reprogramming of neonatal monocytes/macrophages.",
author = "Celia Dechavanne and Odilon Nouatin and Rafiou Adamou and Sofie Edslev and Anita Hansen and Florian Meurisse and Ibrahim Sadissou and Erasme Gbaguidi and Jacqueline Milet and Gilles Cottrell and Laure Gineau and Audrey Sabbagh and Achille Massougbodji and Kabirou Moutairou and Donadi, {Eduardo A} and Carosella, {Edgardo D} and Philippe Moreau and Ed Remarque and Michael Theisen and Nathalie Rouas-Freiss and Andr{\'e} Garcia and Benoit Favier and David Courtin",
note = "Copyright {\textcopyright} 2022 Dechavanne, Nouatin, Adamou, Edslev, Hansen, Meurisse, Sadissou, Gbaguidi, Milet, Cottrell, Gineau, Sabbagh, Massougbodji, Moutairou, Donadi, Carosella, Moreau, Remarque, Theisen, Rouas-Freiss, Garcia, Favier and Courtin.",
year = "2022",
doi = "10.3389/fimmu.2022.909831",
language = "English",
volume = "13",
pages = "909831",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Placental malaria is associated with higher LILRB2 expression in monocyte subsets and lower anti-malarial IgG antibodies during infancy

AU - Dechavanne, Celia

AU - Nouatin, Odilon

AU - Adamou, Rafiou

AU - Edslev, Sofie

AU - Hansen, Anita

AU - Meurisse, Florian

AU - Sadissou, Ibrahim

AU - Gbaguidi, Erasme

AU - Milet, Jacqueline

AU - Cottrell, Gilles

AU - Gineau, Laure

AU - Sabbagh, Audrey

AU - Massougbodji, Achille

AU - Moutairou, Kabirou

AU - Donadi, Eduardo A

AU - Carosella, Edgardo D

AU - Moreau, Philippe

AU - Remarque, Ed

AU - Theisen, Michael

AU - Rouas-Freiss, Nathalie

AU - Garcia, André

AU - Favier, Benoit

AU - Courtin, David

N1 - Copyright © 2022 Dechavanne, Nouatin, Adamou, Edslev, Hansen, Meurisse, Sadissou, Gbaguidi, Milet, Cottrell, Gineau, Sabbagh, Massougbodji, Moutairou, Donadi, Carosella, Moreau, Remarque, Theisen, Rouas-Freiss, Garcia, Favier and Courtin.

PY - 2022

Y1 - 2022

N2 - Background: Placental malaria (PM) is associated with a higher susceptibility of infants to Plasmodium falciparum (Pf) malaria. A hypothesis of immune tolerance has been suggested but no clear explanation has been provided so far. Our goal was to investigate the involvement of inhibitory receptors LILRB1 and LILRB2, known to drive immune evasion upon ligation with pathogen and/or host ligands, in PM-induced immune tolerance.Method: Infants of women with or without PM were enrolled in Allada, southern Benin, and followed-up for 24 months. Antibodies with specificity for five blood stage parasite antigens were quantified by ELISA, and the frequency of immune cell subsets was quantified by flow cytometry. LILRB1 or LILRB2 expression was assessed on cells collected at 18 and 24 months of age.Findings: Infants born to women with PM had a higher risk of developing symptomatic malaria than those born to women without PM (IRR=1.53, p=0.040), and such infants displayed a lower frequency of non-classical monocytes (OR=0.74, p=0.01) that overexpressed LILRB2 (OR=1.36, p=0.002). Moreover, infants born to women with PM had lower levels of cytophilic IgG and higher levels of IL-10 during active infection.Interpretation: Modulation of IgG and IL-10 levels could impair monocyte functions (opsonisation/phagocytosis) in infants born to women with PM, possibly contributing to their higher susceptibility to malaria. The long-lasting effect of PM on infants' monocytes was notable, raising questions about the capacity of ligands such as Rifins or HLA-I molecules to bind to LILRB1 and LILRB2 and to modulate immune responses, and about the reprogramming of neonatal monocytes/macrophages.

AB - Background: Placental malaria (PM) is associated with a higher susceptibility of infants to Plasmodium falciparum (Pf) malaria. A hypothesis of immune tolerance has been suggested but no clear explanation has been provided so far. Our goal was to investigate the involvement of inhibitory receptors LILRB1 and LILRB2, known to drive immune evasion upon ligation with pathogen and/or host ligands, in PM-induced immune tolerance.Method: Infants of women with or without PM were enrolled in Allada, southern Benin, and followed-up for 24 months. Antibodies with specificity for five blood stage parasite antigens were quantified by ELISA, and the frequency of immune cell subsets was quantified by flow cytometry. LILRB1 or LILRB2 expression was assessed on cells collected at 18 and 24 months of age.Findings: Infants born to women with PM had a higher risk of developing symptomatic malaria than those born to women without PM (IRR=1.53, p=0.040), and such infants displayed a lower frequency of non-classical monocytes (OR=0.74, p=0.01) that overexpressed LILRB2 (OR=1.36, p=0.002). Moreover, infants born to women with PM had lower levels of cytophilic IgG and higher levels of IL-10 during active infection.Interpretation: Modulation of IgG and IL-10 levels could impair monocyte functions (opsonisation/phagocytosis) in infants born to women with PM, possibly contributing to their higher susceptibility to malaria. The long-lasting effect of PM on infants' monocytes was notable, raising questions about the capacity of ligands such as Rifins or HLA-I molecules to bind to LILRB1 and LILRB2 and to modulate immune responses, and about the reprogramming of neonatal monocytes/macrophages.

U2 - 10.3389/fimmu.2022.909831

DO - 10.3389/fimmu.2022.909831

M3 - Journal article

C2 - 35911674

VL - 13

SP - 909831

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

ER -

ID: 315290805