Interferon-¿ production by human T cells and natural killer cells in vitro in response to antigens from the two intracellular pathogens Mycobacterium tuberculosis and Leishmania major

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Interferon-¿ production by human T cells and natural killer cells in vitro in response to antigens from the two intracellular pathogens Mycobacterium tuberculosis and Leishmania major. / Kemp, K; Hviid, L; Kharazmi, A; Kemp, M.

In: Scandinavian Journal of Immunology, Vol. 46, No. 5, 1997, p. 495-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kemp, K, Hviid, L, Kharazmi, A & Kemp, M 1997, 'Interferon-¿ production by human T cells and natural killer cells in vitro in response to antigens from the two intracellular pathogens Mycobacterium tuberculosis and Leishmania major', Scandinavian Journal of Immunology, vol. 46, no. 5, pp. 495-9. https://doi.org/10.1046/j.1365-3083.1997.d01-154.x

APA

Kemp, K., Hviid, L., Kharazmi, A., & Kemp, M. (1997). Interferon-¿ production by human T cells and natural killer cells in vitro in response to antigens from the two intracellular pathogens Mycobacterium tuberculosis and Leishmania major. Scandinavian Journal of Immunology, 46(5), 495-9. https://doi.org/10.1046/j.1365-3083.1997.d01-154.x

Vancouver

Kemp K, Hviid L, Kharazmi A, Kemp M. Interferon-¿ production by human T cells and natural killer cells in vitro in response to antigens from the two intracellular pathogens Mycobacterium tuberculosis and Leishmania major. Scandinavian Journal of Immunology. 1997;46(5):495-9. https://doi.org/10.1046/j.1365-3083.1997.d01-154.x

Author

Kemp, K ; Hviid, L ; Kharazmi, A ; Kemp, M. / Interferon-¿ production by human T cells and natural killer cells in vitro in response to antigens from the two intracellular pathogens Mycobacterium tuberculosis and Leishmania major. In: Scandinavian Journal of Immunology. 1997 ; Vol. 46, No. 5. pp. 495-9.

Bibtex

@article{f4025000a06b11dd86a6000ea68e967b,
title = "Interferon-¿ production by human T cells and natural killer cells in vitro in response to antigens from the two intracellular pathogens Mycobacterium tuberculosis and Leishmania major",
abstract = "Acquired resistance to both mycobacteria and Leishmania is primarily mediated by interferon-gamma (IFN-gamma), which triggers mechanisms leading to the death of the microorganism in macrophages. In this study, cell activation and IFN-gamma production was investigated in human peripheral blood mononuclear cells (PBMC) from individuals previously sensitized to tuberculin and without known exposure to Leishmania parasites. Immune staining for intracellular IFN-gamma and surface markers allowed flow cytometric identification of the cellular sources of IFN-gamma in cell cultures incubated with purified protein derivative of tuberculin (PPD) and Leishmania antigens. It was found that IFN-gamma was produced in response to both PPD and Leishmania stimulant by T cells in the cultures. Activation of IFN-gamma producing natural killer (NK) cells was demonstrated only in some cultures, and only with concomitant T cell activation.",
author = "K Kemp and L Hviid and A Kharazmi and M Kemp",
note = "Keywords: Adult; Animals; Antigens, Bacterial; Antigens, CD3; Antigens, CD56; Antigens, Protozoan; BCG Vaccine; Cells, Cultured; Humans; Immunization; Interferon Type II; Killer Cells, Natural; Leishmania major; Lymphocyte Activation; Mycobacterium tuberculosis; T-Lymphocytes; Th1 Cells; Tuberculin",
year = "1997",
doi = "10.1046/j.1365-3083.1997.d01-154.x",
language = "English",
volume = "46",
pages = "495--9",
journal = "Scandinavian Journal of Immunology, Supplement",
issn = "0301-6323",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - Interferon-¿ production by human T cells and natural killer cells in vitro in response to antigens from the two intracellular pathogens Mycobacterium tuberculosis and Leishmania major

AU - Kemp, K

AU - Hviid, L

AU - Kharazmi, A

AU - Kemp, M

N1 - Keywords: Adult; Animals; Antigens, Bacterial; Antigens, CD3; Antigens, CD56; Antigens, Protozoan; BCG Vaccine; Cells, Cultured; Humans; Immunization; Interferon Type II; Killer Cells, Natural; Leishmania major; Lymphocyte Activation; Mycobacterium tuberculosis; T-Lymphocytes; Th1 Cells; Tuberculin

PY - 1997

Y1 - 1997

N2 - Acquired resistance to both mycobacteria and Leishmania is primarily mediated by interferon-gamma (IFN-gamma), which triggers mechanisms leading to the death of the microorganism in macrophages. In this study, cell activation and IFN-gamma production was investigated in human peripheral blood mononuclear cells (PBMC) from individuals previously sensitized to tuberculin and without known exposure to Leishmania parasites. Immune staining for intracellular IFN-gamma and surface markers allowed flow cytometric identification of the cellular sources of IFN-gamma in cell cultures incubated with purified protein derivative of tuberculin (PPD) and Leishmania antigens. It was found that IFN-gamma was produced in response to both PPD and Leishmania stimulant by T cells in the cultures. Activation of IFN-gamma producing natural killer (NK) cells was demonstrated only in some cultures, and only with concomitant T cell activation.

AB - Acquired resistance to both mycobacteria and Leishmania is primarily mediated by interferon-gamma (IFN-gamma), which triggers mechanisms leading to the death of the microorganism in macrophages. In this study, cell activation and IFN-gamma production was investigated in human peripheral blood mononuclear cells (PBMC) from individuals previously sensitized to tuberculin and without known exposure to Leishmania parasites. Immune staining for intracellular IFN-gamma and surface markers allowed flow cytometric identification of the cellular sources of IFN-gamma in cell cultures incubated with purified protein derivative of tuberculin (PPD) and Leishmania antigens. It was found that IFN-gamma was produced in response to both PPD and Leishmania stimulant by T cells in the cultures. Activation of IFN-gamma producing natural killer (NK) cells was demonstrated only in some cultures, and only with concomitant T cell activation.

U2 - 10.1046/j.1365-3083.1997.d01-154.x

DO - 10.1046/j.1365-3083.1997.d01-154.x

M3 - Journal article

C2 - 9393632

VL - 46

SP - 495

EP - 499

JO - Scandinavian Journal of Immunology, Supplement

JF - Scandinavian Journal of Immunology, Supplement

SN - 0301-6323

IS - 5

ER -

ID: 6748150