Fcγ receptor IIIB NA1/NA2/SH polymorphisms are associated with malaria susceptibility and antibody levels to P. falciparum merozoite antigens in Beninese children

Research output: Contribution to journal › Journal article › Research › peer-review

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Fcγ receptor IIIB NA1/NA2/SH polymorphisms are associated with malaria susceptibility and antibody levels to P. falciparum merozoite antigens in Beninese children. / Fall, Abdou Khadre Dit Jadir; Courtin, David; Adamou, Rafiou; Edslev, Sofie; Hansen, Anita; Domingo, Nadia; Christiansen, Michael; Adu, Bright; Milet, Jacqueline; Garcia, André; Theisen, Michael; Migot-Nabias, Florence; Dechavanne, Célia.

In: International Journal of Molecular Sciences, Vol. 23, No. 23, 14882, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Fall, AKDJ, Courtin, D, Adamou, R, Edslev, S, Hansen, A, Domingo, N, Christiansen, M, Adu, B, Milet, J, Garcia, A, Theisen, M, Migot-Nabias, F & Dechavanne, C 2022, 'Fcγ receptor IIIB NA1/NA2/SH polymorphisms are associated with malaria susceptibility and antibody levels to P. falciparum merozoite antigens in Beninese children', International Journal of Molecular Sciences, vol. 23, no. 23, 14882. https://doi.org/10.3390/ijms232314882

APA

Fall, A. K. D. J., Courtin, D., Adamou, R., Edslev, S., Hansen, A., Domingo, N., Christiansen, M., Adu, B., Milet, J., Garcia, A., Theisen, M., Migot-Nabias, F., & Dechavanne, C. (2022). Fcγ receptor IIIB NA1/NA2/SH polymorphisms are associated with malaria susceptibility and antibody levels to P. falciparum merozoite antigens in Beninese children. International Journal of Molecular Sciences, 23(23), [14882]. https://doi.org/10.3390/ijms232314882

Vancouver

Fall AKDJ, Courtin D, Adamou R, Edslev S, Hansen A, Domingo N et al. Fcγ receptor IIIB NA1/NA2/SH polymorphisms are associated with malaria susceptibility and antibody levels to P. falciparum merozoite antigens in Beninese children. International Journal of Molecular Sciences. 2022;23(23). 14882. https://doi.org/10.3390/ijms232314882

Author

Fall, Abdou Khadre Dit Jadir ; Courtin, David ; Adamou, Rafiou ; Edslev, Sofie ; Hansen, Anita ; Domingo, Nadia ; Christiansen, Michael ; Adu, Bright ; Milet, Jacqueline ; Garcia, André ; Theisen, Michael ; Migot-Nabias, Florence ; Dechavanne, Célia. / Fcγ receptor IIIB NA1/NA2/SH polymorphisms are associated with malaria susceptibility and antibody levels to P. falciparum merozoite antigens in Beninese children. In: International Journal of Molecular Sciences. 2022 ; Vol. 23, No. 23.

Bibtex

@article{642970e7962b4377bdc57855b3e610c6,
title = "Fcγ receptor IIIB NA1/NA2/SH polymorphisms are associated with malaria susceptibility and antibody levels to P. falciparum merozoite antigens in Beninese children",
abstract = "This paper aimed to investigate the influence of polymorphisms in the FCGR2A gene encoding R131H FcgRIIA variants and in the FCGR3B gene (108G > C, 114C > T, 194 A > G, 233C > A, 244 G > A and 316G > A) encoding FcgRIIIB-NA1, -NA2 and -SH variants on malaria susceptibility and antibody responses against P. falciparum merozoite antigens in Beninese children. An active malaria follow-up was conducted in infants from birth to 24 months of age in Allada, Benin. FCGR3B exon 3 was sequenced and FCGR2A exon 4 was genotyped. Antibodies directed to GLURP and MSP3 were quantified by ELISA. Association studies were performed using mixed-effect models. Individual carriage of FCGR3B 194 AA genotype was associated with a high number of malaria infections and a low level of IgG1 against MSP3 and GLURP-R0. High parasitemia and increased malaria infections were observed in infants carrying the FCGR3B*05 108C-114T-194A-233C-244A-316A haplotype. A reduced risk of malaria infections and low parasitemia were related to the carriages of the FCGR3B 108C-114T-194G-233C-244G-316A (FCGR3B*06), FCGR3B 108C-114T-194G-233A-244A-316A (FCGR3B*03 encoding for FcgRIIIB-SH) haplotypes and FCGR3B 297 TT genotype. Our results highlight the impact of FCGR3B polymorphisms on the individual susceptibility to malaria and antibody responses against MSP3 and GLURP in Beninese children.",
author = "Fall, {Abdou Khadre Dit Jadir} and David Courtin and Rafiou Adamou and Sofie Edslev and Anita Hansen and Nadia Domingo and Michael Christiansen and Bright Adu and Jacqueline Milet and Andr{\'e} Garcia and Michael Theisen and Florence Migot-Nabias and C{\'e}lia Dechavanne",
year = "2022",
doi = "10.3390/ijms232314882",
language = "English",
volume = "23",
journal = "International Journal of Molecular Sciences (CD-ROM)",
issn = "1424-6783",
publisher = "M D P I AG",
number = "23",

}

RIS

TY - JOUR

T1 - Fcγ receptor IIIB NA1/NA2/SH polymorphisms are associated with malaria susceptibility and antibody levels to P. falciparum merozoite antigens in Beninese children

AU - Fall, Abdou Khadre Dit Jadir

AU - Courtin, David

AU - Adamou, Rafiou

AU - Edslev, Sofie

AU - Hansen, Anita

AU - Domingo, Nadia

AU - Christiansen, Michael

AU - Adu, Bright

AU - Milet, Jacqueline

AU - Garcia, André

AU - Theisen, Michael

AU - Migot-Nabias, Florence

AU - Dechavanne, Célia

PY - 2022

Y1 - 2022

N2 - This paper aimed to investigate the influence of polymorphisms in the FCGR2A gene encoding R131H FcgRIIA variants and in the FCGR3B gene (108G > C, 114C > T, 194 A > G, 233C > A, 244 G > A and 316G > A) encoding FcgRIIIB-NA1, -NA2 and -SH variants on malaria susceptibility and antibody responses against P. falciparum merozoite antigens in Beninese children. An active malaria follow-up was conducted in infants from birth to 24 months of age in Allada, Benin. FCGR3B exon 3 was sequenced and FCGR2A exon 4 was genotyped. Antibodies directed to GLURP and MSP3 were quantified by ELISA. Association studies were performed using mixed-effect models. Individual carriage of FCGR3B 194 AA genotype was associated with a high number of malaria infections and a low level of IgG1 against MSP3 and GLURP-R0. High parasitemia and increased malaria infections were observed in infants carrying the FCGR3B*05 108C-114T-194A-233C-244A-316A haplotype. A reduced risk of malaria infections and low parasitemia were related to the carriages of the FCGR3B 108C-114T-194G-233C-244G-316A (FCGR3B*06), FCGR3B 108C-114T-194G-233A-244A-316A (FCGR3B*03 encoding for FcgRIIIB-SH) haplotypes and FCGR3B 297 TT genotype. Our results highlight the impact of FCGR3B polymorphisms on the individual susceptibility to malaria and antibody responses against MSP3 and GLURP in Beninese children.

AB - This paper aimed to investigate the influence of polymorphisms in the FCGR2A gene encoding R131H FcgRIIA variants and in the FCGR3B gene (108G > C, 114C > T, 194 A > G, 233C > A, 244 G > A and 316G > A) encoding FcgRIIIB-NA1, -NA2 and -SH variants on malaria susceptibility and antibody responses against P. falciparum merozoite antigens in Beninese children. An active malaria follow-up was conducted in infants from birth to 24 months of age in Allada, Benin. FCGR3B exon 3 was sequenced and FCGR2A exon 4 was genotyped. Antibodies directed to GLURP and MSP3 were quantified by ELISA. Association studies were performed using mixed-effect models. Individual carriage of FCGR3B 194 AA genotype was associated with a high number of malaria infections and a low level of IgG1 against MSP3 and GLURP-R0. High parasitemia and increased malaria infections were observed in infants carrying the FCGR3B*05 108C-114T-194A-233C-244A-316A haplotype. A reduced risk of malaria infections and low parasitemia were related to the carriages of the FCGR3B 108C-114T-194G-233C-244G-316A (FCGR3B*06), FCGR3B 108C-114T-194G-233A-244A-316A (FCGR3B*03 encoding for FcgRIIIB-SH) haplotypes and FCGR3B 297 TT genotype. Our results highlight the impact of FCGR3B polymorphisms on the individual susceptibility to malaria and antibody responses against MSP3 and GLURP in Beninese children.

U2 - 10.3390/ijms232314882

DO - 10.3390/ijms232314882

M3 - Journal article

C2 - 36499205

VL - 23

JO - International Journal of Molecular Sciences (CD-ROM)

JF - International Journal of Molecular Sciences (CD-ROM)

SN - 1424-6783

IS - 23

M1 - 14882

ER -

ID: 328440632