Association of Immunoglobulin G3 Hinge Region Length Polymorphism With Cerebral Malaria in Ghanaian Children

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Association of Immunoglobulin G3 Hinge Region Length Polymorphism With Cerebral Malaria in Ghanaian Children. / Kyei-Baafour, Eric; Kusi, Kwadwo A.; Arthur, Fareed K.N.; Sarkodie-Addo, Tracy; Theisen, Michael; Dodoo, Daniel; Adu, Bright.

In: The Journal of Infectious Diseases, Vol. 225, No. 10, 2022, p. 1786-1790.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kyei-Baafour, E, Kusi, KA, Arthur, FKN, Sarkodie-Addo, T, Theisen, M, Dodoo, D & Adu, B 2022, 'Association of Immunoglobulin G3 Hinge Region Length Polymorphism With Cerebral Malaria in Ghanaian Children', The Journal of Infectious Diseases, vol. 225, no. 10, pp. 1786-1790. https://doi.org/10.1093/infdis/jiab548

APA

Kyei-Baafour, E., Kusi, K. A., Arthur, F. K. N., Sarkodie-Addo, T., Theisen, M., Dodoo, D., & Adu, B. (2022). Association of Immunoglobulin G3 Hinge Region Length Polymorphism With Cerebral Malaria in Ghanaian Children. The Journal of Infectious Diseases, 225(10), 1786-1790. https://doi.org/10.1093/infdis/jiab548

Vancouver

Kyei-Baafour E, Kusi KA, Arthur FKN, Sarkodie-Addo T, Theisen M, Dodoo D et al. Association of Immunoglobulin G3 Hinge Region Length Polymorphism With Cerebral Malaria in Ghanaian Children. The Journal of Infectious Diseases. 2022;225(10):1786-1790. https://doi.org/10.1093/infdis/jiab548

Author

Kyei-Baafour, Eric ; Kusi, Kwadwo A. ; Arthur, Fareed K.N. ; Sarkodie-Addo, Tracy ; Theisen, Michael ; Dodoo, Daniel ; Adu, Bright. / Association of Immunoglobulin G3 Hinge Region Length Polymorphism With Cerebral Malaria in Ghanaian Children. In: The Journal of Infectious Diseases. 2022 ; Vol. 225, No. 10. pp. 1786-1790.

Bibtex

@article{bb0f0506f73e44f1bc561ea83e8d5ac1,
title = "Association of Immunoglobulin G3 Hinge Region Length Polymorphism With Cerebral Malaria in Ghanaian Children",
abstract = "Cerebral malaria (CM) may cause death or long-term neurological damage in children, and several host genetic risk factors have been reported. Malaria-specific immunoglobulin (Ig) G3 antibodies are crucial to human immune response against malaria. The hinge region of IgG3 exhibits length polymorphism (with long [L], medium [M], and short [S] alleles), which may influence its functionality. We studied IgG3 hinge region length polymorphisms in 136 Ghanaian children with malaria. Using logistic regression models, we found that children with the recessive MM allotype encoding medium IgG3 hinge region length had an increased risk of CM (adjusted odds ratio, 6.67 [95% confidence interval,1.30-34.32]; P=.004) . This has implications for future epidemiological studies on CM.",
keywords = "IGHG3 gene, cerebral malaria, IgG3 hinge region, Plasmodium falciparum, polymorphism",
author = "Eric Kyei-Baafour and Kusi, {Kwadwo A.} and Arthur, {Fareed K.N.} and Tracy Sarkodie-Addo and Michael Theisen and Daniel Dodoo and Bright Adu",
note = "Publisher Copyright: {\textcopyright} The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",
year = "2022",
doi = "10.1093/infdis/jiab548",
language = "English",
volume = "225",
pages = "1786--1790",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "10",

}

RIS

TY - JOUR

T1 - Association of Immunoglobulin G3 Hinge Region Length Polymorphism With Cerebral Malaria in Ghanaian Children

AU - Kyei-Baafour, Eric

AU - Kusi, Kwadwo A.

AU - Arthur, Fareed K.N.

AU - Sarkodie-Addo, Tracy

AU - Theisen, Michael

AU - Dodoo, Daniel

AU - Adu, Bright

N1 - Publisher Copyright: © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

PY - 2022

Y1 - 2022

N2 - Cerebral malaria (CM) may cause death or long-term neurological damage in children, and several host genetic risk factors have been reported. Malaria-specific immunoglobulin (Ig) G3 antibodies are crucial to human immune response against malaria. The hinge region of IgG3 exhibits length polymorphism (with long [L], medium [M], and short [S] alleles), which may influence its functionality. We studied IgG3 hinge region length polymorphisms in 136 Ghanaian children with malaria. Using logistic regression models, we found that children with the recessive MM allotype encoding medium IgG3 hinge region length had an increased risk of CM (adjusted odds ratio, 6.67 [95% confidence interval,1.30-34.32]; P=.004) . This has implications for future epidemiological studies on CM.

AB - Cerebral malaria (CM) may cause death or long-term neurological damage in children, and several host genetic risk factors have been reported. Malaria-specific immunoglobulin (Ig) G3 antibodies are crucial to human immune response against malaria. The hinge region of IgG3 exhibits length polymorphism (with long [L], medium [M], and short [S] alleles), which may influence its functionality. We studied IgG3 hinge region length polymorphisms in 136 Ghanaian children with malaria. Using logistic regression models, we found that children with the recessive MM allotype encoding medium IgG3 hinge region length had an increased risk of CM (adjusted odds ratio, 6.67 [95% confidence interval,1.30-34.32]; P=.004) . This has implications for future epidemiological studies on CM.

KW - IGHG3 gene

KW - cerebral malaria

KW - IgG3 hinge region

KW - Plasmodium falciparum

KW - polymorphism

U2 - 10.1093/infdis/jiab548

DO - 10.1093/infdis/jiab548

M3 - Journal article

C2 - 34718631

AN - SCOPUS:85130765425

VL - 225

SP - 1786

EP - 1790

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 10

ER -

ID: 308890758