Lea Klingenberg Barfod

Lea Klingenberg Barfod

Associate Professor

Member of:

  • EPITOPE team

ORCID: 0000-0001-6510-495X

Publication year:
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1 - 25 out of 38Page size: 25
  1. 2024
  2. Published

    Atypical memory B cell frequency correlates with antibody breadth and function in malaria immune adults

    Partey, Frederica Dedo, Dowuona, J. N. N., Pobee, A. N. A., Walker, Melanie Rose, Aculley, B., Prah, D. A., Ofori, M. F. & Barfod, Lea Klingenberg, 28 Feb 2024, In: Scientific Reports. 14, 1, 11 p., 4888.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. 2023
  4. Published

    A complex equation - adding to Plasmodium falciparum invasion

    Björnsson, K. H. & Barfod, Lea Klingenberg, 2023, In: Trends in Parasitology. 39, 3, p. 160-162 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Characterization of SARS-CoV-2 humoral immune response in a subject with unique sampling: A case report

    Walker, Melanie Rose, Idorn, M., Bennett, Anja, Søgaard, M., Salanti, Ali, Ditlev, S. B. & Barfod, Lea Klingenberg, 2023, In: Immunity, Inflammation and Disease. 11, 6, e910.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. 2022
  7. Published

    Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1.4 broadly reacting with polymorphic malarial protein VAR2CSA

    Raghavan, Sai Sundar Rajan, Dagil, Robert, Lopez-Perez, Mary, Conrad, J., Bassi, Maria Rosaria, Quintana Varon, Maria del Pilar, Choudhary, Swati, Gustavsson, Tobias, Wang, Y., Gourdon, Pontus Emanuel, Ofori, M. F., Christensen, S. B., Minja, D. T. R., Schmiegelow, Christentze, Nielsen, Morten Agertoug, Barfod, Lea Klingenberg, Hviid, Lars, Salanti, Ali, Lavstsen, Thomas & Wang, Kaituo, 2022, In: PLoS Pathogens. 18, 11, e1010924.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Enhancing neutralization of Plasmodium falciparum using a novel monoclonal antibody against the rhoptry-associated membrane antigen

    Knudsen, Anne Schlitterlau, Walker, Melanie Rose, Agullet, J. P., Björnsson, K. H., Bassi, Maria Rosaria & Barfod, Lea Klingenberg, 2022, In: Scientific Reports. 12, 1, 3040.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Production of PfEMP1-specific human monoclonal antibodies from naturally immune individuals

    Walker, Melanie Rose & Barfod, Lea Klingenberg, 2022, Malaria Immunology: Targeting the Surface of Infected Erythrocytes. Humana Press, Vol. 2470. p. 407-421 15 p. (Methods in molecular biology (Clifton, N.J.)).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  10. Published

    Production of PfEMP1-specific mouse monoclonal antibodies

    Dalgaard, Nanna & Barfod, Lea Klingenberg, 2022, Malaria Immunology: Targeting the Surface of Infected Erythrocytes. Humana Press, Vol. 2470. p. 391-405 15 p. (Methods in Molecular Biology; No. 2470).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  11. Published

    SARS-CoV-2 RBD-specific antibodies induced early in the pandemic by natural infection and vaccination display cross-variant binding and inhibition

    Walker, Melanie Rose, Podlekareva, D., Johnsen, Stine, Leerhøy, B., Fougeroux, Cyrielle Elyette, Søgaard, M., Salanti, Ali, Ditlev, S. B. & Barfod, Lea Klingenberg, 2022, In: Viruses. 14, 9, 14 p., 1861.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. 2021

  13. Protein/AS01B vaccination elicits stronger, more Th2-skewed antigen-specific human T follicular helper cell responses than heterologous viral vectors

    Nielsen, C. M., Ogbe, A., Pedroza-Pacheco, I., Doeleman, S. E., Chen, Y., Silk, S. E., Barrett, J. R., Elias, S. C., Miura, K., Diouf, A., Bardelli, M., Dabbs, R. A., Barfod, Lea Klingenberg, Long, C. A., Haynes, B. F., Payne, R. O., Minassian, A. M., Bradley, T., Draper, S. J. & Borrow, P., 2021, In: Cell Reports Medicine. 2, 3, 100207.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Reduced blood-stage malaria growth and immune correlates in humans following RH5 vaccination

    Minassian, A. M., Silk, S. E., Barrett, J. R., Nielsen, C. M., Miura, K., Diouf, A., Loos, C., Fallon, J. K., Michell, A. R., White, M. T., Edwards, N. J., Poulton, I. D., Mitton, C. H., Payne, R. O., Marks, M., Maxwell-Scott, H., Querol-Rubiera, A., Bisnauthsing, K., Batra, R., Ogrina, T. & 30 others, Brendish, N. J., Themistocleous, Y., Rawlinson, T. A., Ellis, K. J., Quinkert, D., Baker, M., Lopez Ramon, R., Ramos Lopez, F., Barfod, Lea Klingenberg, Folegatti, P. M., Silman, D., Datoo, M., Taylor, I. J., Jin, J., Pulido, D., Douglas, A. D., de Jongh, W. A., Smith, R., Berrie, E., Noe, A. R., Diggs, C. L., Soisson, L. A., Ashfield, R., Faust, S. N., Goodman, A. L., Lawrie, A. M., Nugent, F. L., Alter, G., Long, C. A. & Draper, S. J., 2021, In: Med. 2, 6, p. 701-719

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Strain-Dependent Inhibition of Erythrocyte Invasion by Monoclonal Antibodies Against Plasmodium falciparum CyRPA

    Knudsen, Anne Schlitterlau, Björnsson, K. H., Bassi, Maria Rosaria, Walker, Melanie Rose, Kok, A., Cristinoi, B., Jensen, Anja Ramstedt & Barfod, Lea Klingenberg, 2021, In: Frontiers in Immunology. 12, 716305.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. 2020
  17. Published

    The structure of the cysteine-rich domain of Plasmodium falciparum P113 identifies the location of the RH5 binding site

    Campeotto, I., Galaway, F., Mehmood, S., Barfod, Lea Klingenberg, Quinkert, D., Kotraiah, V., Phares, T. W., Wright, K. E., Snijders, A. P., Draper, S. J., Higgins, M. K. & Wright, G. J., 8 Sep 2020, In: mBio. 11, 5, e01566-20.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Acquisition and decay of IgM and IgG responses to merozoite antigens after Plasmodium falciparum malaria in Ghanaian children

    Walker, Melanie Rose, Knudsen, Anne Schlitterlau, Partey, Frederica Dedo, Bassi, Maria Rosaria, Frank, A. M., Castberg, F. C., Sarbah, E. W., Ofori, M. F., Hviid, Lars & Barfod, Lea Klingenberg, 2020, In: PLoS ONE. 15, 12, p. e0243943

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. 2019

  20. Functional comparison of blood-stage Plasmodium falciparum malaria vaccine candidate antigens

    Illingworth, J. J., Alanine, D. G., Brown, R., Marshall, J. M., Bartlett, H. E., Silk, S. E., Labbé, G. M., Quinkert, D., Cho, J. S., Wendler, J. P., Pattinson, D. J., Barfod, Lea Klingenberg, Douglas, A. D., Shea, M. W., Wright, K. E., de Cassan, S. C., Higgins, M. K. & Draper, S. J., 2019, In: Frontiers in Immunology. 10, p. 1254

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. 2018
  22. Published

    Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria

    Partey, Frederica Dedo, Castberg, F. C., Sarbah, E. W., Silk, S. E., Awandare, G. A., Draper, S. J., Opoku, N., Kweku, M., Ofori, M. F., Hviid, Lars & Barfod, Lea Klingenberg, 2018, In: PLOS ONE. 13, 6, 14 p., e0198371.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. 2017
  24. Published

    Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions

    Payne, R. O., Silk, S. E., Elias, S. C., Miura, K., Diouf, A., Galaway, F., de Graaf, H., Brendish, N. J., Poulton, I. D., Griffiths, O. J., Edwards, N. J., Jin, J., Labbé, G. M., Alanine, D. G., Siani, L., Di Marco, S., Roberts, R., Green, N., Berrie, E., Ishizuka, A. S. & 22 others, Nielsen, C. M., Bardelli, M., Partey, Frederica Dedo, Ofori, M. F., Barfod, Lea Klingenberg, Wambua, J., Murungi, L. M., Osier, F. H., Biswas, S., McCarthy, J. S., Minassian, A. M., Ashfield, R., Viebig, N. K., Nugent, F. L., Douglas, A. D., Vekemans, J., Wright, G. J., Faust, S. N., Hill, A. V., Long, C. A., Lawrie, A. M. & Draper, S. J., Nov 2017, In: JCI insight. 2, 21, 19 p., e96381.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. One-step design of a stable variant of the malaria invasion protein RH5 for use as a vaccine immunogen

    Campeotto, I., Goldenzweig, A., Davey, J., Barfod, Lea Klingenberg, Marshall, J. M., Silk, S. E., Wright, K. E., Draper, S. J., Higgins, M. K. & Fleishman, S. J., Jan 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 5, p. 998-1002 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. 2015
  27. Published

    α2-macroglobulin can crosslink multiple Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) molecules and may facilitate adhesion of parasitized erythrocytes

    Stevenson, L., Laursen, E., Cowan, G. J., Bandoh, B., Barfod, Lea Klingenberg, Cavanagh, D. R., Andersen, G. R. & Hviid, Lars, Jul 2015, In: P L o S Pathogens. 11, 7, p. 1-19 19 p., e1005022.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Investigating the function of Fc -specific binding of IgM to Plasmodium falciparum erythrocyte membrane protein 1 mediating erythrocyte rosetting

    Stevenson, L., Huda, P., Jeppesen, A., Laursen, E. T. F., Rowe, J. A., Craig, A., Streicher, W., Barfod, Lea Klingenberg & Hviid, Lars, Jun 2015, In: Cellular Microbiology. 17, 6, p. 819-31 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Trying to remember: immunological B cell memory to malaria

    Hviid, Lars, Barfod, Lea Klingenberg & Fowkes, F. J. I., Mar 2015, In: Trends in Parasitology. 31, 3, p. 89-94 6 p.

    Research output: Contribution to journal › Review › Research › peer-review

  30. Published

    Plasmodium falciparum-infected erythrocyte knob density is linked to the PfEMP1 variant expressed

    Subramani, R., Quadt, K., Jeppesen, A. E., Hempel, C., Petersen, J. E. V., Hassenkam, Tue, Hviid, Lars & Barfod, Lea Klingenberg, 2015, In: mBio. 6, 5, 7 p., e01456-15.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Mapping the binding site of a cross-reactive Plasmodium falciparum PfEMP1 monoclonal antibody inhibitory of ICAM-1 binding

    Lennartz, F., Bengtsson, A., Olsen, Rebecca Wendelboe, Joergensen, L., Brown, A., Remy, L., Man, P., Forest, E., Barfod, Lea Klingenberg, Adams, Yvonne, Higgins, M. K. & Jensen, Anja Ramstedt, 2015, In: Journal of immunology (Baltimore, Md. : 1950). 195, 7, p. 3273-83 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Multiple Plasmodium falciparum erythrocyte membrane protein 1 variants per genome can bind IgM via its Fc fragment Fcμ

    Jeppesen, A., Ditlev, S. B., Soroka, V., Stevenson, E. K., Turner, Louise, Dzikowski, R., Hviid, Lars & Barfod, Lea Klingenberg, 2015, In: Infection and Immunity. 83, 10, p. 3972-81 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. 2014
  34. Published

    Kinetics of B Cell responses to Plasmodium falciparum erythrocyte membrane protein 1 in Ghanaian women naturally exposed to malaria parasites

    Ampomah, P., Stevenson, L., Ofori, M. F., Barfod, Lea Klingenberg & Hviid, Lars, 1 Jun 2014, In: Journal of Immunology. 192, 11, p. 5236-44 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    B-cell responses to pregnancy-restricted and -unrestricted Plasmodium falciparum erythrocyte membrane protein 1 antigens in Ghanaian women naturally exposed to malaria parasites

    Ampomah, P., Stevenson, L., Ofori, M. F., Barfod, Lea Klingenberg & Hviid, Lars, May 2014, In: Infection and Immunity. 82, 5, p. 1860-71 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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