The antimalarial drug, Ro 42-1611 (arteflene), does not affect cytoadherence and cytokine-inducing properties of Plasmodium falciparum malaria parasites
Research output: Contribution to journal › Journal article › Research › peer-review
The purpose of this study was to investigate the ability of the antimalarial drug, Ro 42-1611 to block parasite mediated cytokine induction in vitro as well as cytoadherence of infected erythrocytes to melanoma cells in vitro. The biological activity of Ro 42-1611 was confirmed as it blocked Plasmodium falciparum growth in cultures. Ro 42-1611, had no major effect on TNF, IL-alpha or IL-6 cytokine release from mononuclear cells stimulated with malaria antigens or lipopolysaccharide and it did not affect cell viability. Ro 42-1611 only slightly suppressed cytoadherence of infected erythrocytes to melanoma cells. The therapeutic effect of To 42-1611 appears to be confined to its parasite killing activity.
Original language | English |
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Journal | Tropical Medicine and Parasitology |
Volume | 46 |
Issue number | 2 |
Pages (from-to) | 88-92 |
Number of pages | 4 |
ISSN | 0177-2392 |
Publication status | Published - 1995 |
Bibliographical note
Keywords: Adult; Animals; Antigens, Protozoan; Antimalarials; Artemisinins; Bicyclo Compounds, Heterocyclic; Cell Adhesion; Cell Survival; Chloroquine; Cytokines; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Erythrocytes; Humans; Immunoglobulin G; Interleukin-1; Interleukin-6; Lipopolysaccharides; Lymphocytes; Malaria, Falciparum; Mefloquine; Melanoma; Plasmodium falciparum; Styrenes; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha
ID: 18106381