Modifications of the alpha,beta-double bond in chalcones only marginally affect the antiprotozoal activities

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Modifications of the alpha,beta-double bond in chalcones only marginally affect the antiprotozoal activities. / Nielsen, S F; Kharazmi, A; Christensen, S B.

In: Bioorganic & Medicinal Chemistry, Vol. 6, No. 7, 1998, p. 937-45.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nielsen, SF, Kharazmi, A & Christensen, SB 1998, 'Modifications of the alpha,beta-double bond in chalcones only marginally affect the antiprotozoal activities', Bioorganic & Medicinal Chemistry, vol. 6, no. 7, pp. 937-45.

APA

Nielsen, S. F., Kharazmi, A., & Christensen, S. B. (1998). Modifications of the alpha,beta-double bond in chalcones only marginally affect the antiprotozoal activities. Bioorganic & Medicinal Chemistry, 6(7), 937-45.

Vancouver

Nielsen SF, Kharazmi A, Christensen SB. Modifications of the alpha,beta-double bond in chalcones only marginally affect the antiprotozoal activities. Bioorganic & Medicinal Chemistry. 1998;6(7):937-45.

Author

Nielsen, S F ; Kharazmi, A ; Christensen, S B. / Modifications of the alpha,beta-double bond in chalcones only marginally affect the antiprotozoal activities. In: Bioorganic & Medicinal Chemistry. 1998 ; Vol. 6, No. 7. pp. 937-45.

Bibtex

@article{22c06aa01bcf11df8ed1000ea68e967b,
title = "Modifications of the alpha,beta-double bond in chalcones only marginally affect the antiprotozoal activities",
abstract = "Methods for selective alkylation of chalcones in the alpha- or beta-position and for selective reduction of the alpha,beta-double bond have been developed. The antiparasitic potencies of the alpha,beta-double bond modified chalcones only differ marginally from the potencies of the parent chalcones indicating that the propenone residue only functions as a spacer between the two benzene rings, which are the true pharmacophore.",
author = "Nielsen, {S F} and A Kharazmi and Christensen, {S B}",
note = "Keywords: Animals; Antimalarials; Chalcone; Erythrocytes; Leishmania major; Plasmodium falciparum; Structure-Activity Relationship; Trypanocidal Agents",
year = "1998",
language = "English",
volume = "6",
pages = "937--45",
journal = "Bioorganic & Medicinal Chemistry",
issn = "0968-0896",
publisher = "Pergamon Press",
number = "7",

}

RIS

TY - JOUR

T1 - Modifications of the alpha,beta-double bond in chalcones only marginally affect the antiprotozoal activities

AU - Nielsen, S F

AU - Kharazmi, A

AU - Christensen, S B

N1 - Keywords: Animals; Antimalarials; Chalcone; Erythrocytes; Leishmania major; Plasmodium falciparum; Structure-Activity Relationship; Trypanocidal Agents

PY - 1998

Y1 - 1998

N2 - Methods for selective alkylation of chalcones in the alpha- or beta-position and for selective reduction of the alpha,beta-double bond have been developed. The antiparasitic potencies of the alpha,beta-double bond modified chalcones only differ marginally from the potencies of the parent chalcones indicating that the propenone residue only functions as a spacer between the two benzene rings, which are the true pharmacophore.

AB - Methods for selective alkylation of chalcones in the alpha- or beta-position and for selective reduction of the alpha,beta-double bond have been developed. The antiparasitic potencies of the alpha,beta-double bond modified chalcones only differ marginally from the potencies of the parent chalcones indicating that the propenone residue only functions as a spacer between the two benzene rings, which are the true pharmacophore.

M3 - Journal article

C2 - 9730229

VL - 6

SP - 937

EP - 945

JO - Bioorganic & Medicinal Chemistry

JF - Bioorganic & Medicinal Chemistry

SN - 0968-0896

IS - 7

ER -

ID: 18054504