Complement and immunoglobulin studies in 15 cases of chronic meningococcemia: Properdin deficiency and hypoimmunoglobulinemia

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Complement and immunoglobulin studies in 15 cases of chronic meningococcemia : Properdin deficiency and hypoimmunoglobulinemia. / Nielsen, Hans Erik; Koch, Claus; Mansa, Bendt; Magnussen, Pascal; Bergmann, Olav J.

In: Scandinavian Journal of Infectious Diseases, Vol. 22, No. 1, 01.01.1990, p. 31-36.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nielsen, HE, Koch, C, Mansa, B, Magnussen, P & Bergmann, OJ 1990, 'Complement and immunoglobulin studies in 15 cases of chronic meningococcemia: Properdin deficiency and hypoimmunoglobulinemia', Scandinavian Journal of Infectious Diseases, vol. 22, no. 1, pp. 31-36. https://doi.org/10.3109/00365549009023116

APA

Nielsen, H. E., Koch, C., Mansa, B., Magnussen, P., & Bergmann, O. J. (1990). Complement and immunoglobulin studies in 15 cases of chronic meningococcemia: Properdin deficiency and hypoimmunoglobulinemia. Scandinavian Journal of Infectious Diseases, 22(1), 31-36. https://doi.org/10.3109/00365549009023116

Vancouver

Nielsen HE, Koch C, Mansa B, Magnussen P, Bergmann OJ. Complement and immunoglobulin studies in 15 cases of chronic meningococcemia: Properdin deficiency and hypoimmunoglobulinemia. Scandinavian Journal of Infectious Diseases. 1990 Jan 1;22(1):31-36. https://doi.org/10.3109/00365549009023116

Author

Nielsen, Hans Erik ; Koch, Claus ; Mansa, Bendt ; Magnussen, Pascal ; Bergmann, Olav J. / Complement and immunoglobulin studies in 15 cases of chronic meningococcemia : Properdin deficiency and hypoimmunoglobulinemia. In: Scandinavian Journal of Infectious Diseases. 1990 ; Vol. 22, No. 1. pp. 31-36.

Bibtex

@article{17a75683b4ef4b3f866deab5ec538c2c,
title = "Complement and immunoglobulin studies in 15 cases of chronic meningococcemia: Properdin deficiency and hypoimmunoglobulinemia",
abstract = "The purpose of this study was to investigate whether patients with chronic meningococcemia have abnormalities in their humoral immune system. The alternative and classical complement system, the levels of IgA, IgG and IgM, as well as IgG subclasses were studied in 15 individuals who had recovered from chronic meningococcemia. We found one individual with complete deficiency of properdin, a component of the alternative complement pathway. In the other patients, the complement system was normal. The mean plasma IgG concentration was significantly below normal in the patient group, while the mean values of IgA, IgM and the IgG subclasses were normal. Two individuals, however, had low IgG2 and IgG4 levels. We conclude that properdin deficiency and reduced plasma IgG levels may predispose to chronic meningococcal disease, but that the majority of patients with chronic meningococcemia have a normal humoral immune system.",
author = "Nielsen, {Hans Erik} and Claus Koch and Bendt Mansa and Pascal Magnussen and Bergmann, {Olav J.}",
year = "1990",
month = jan,
day = "1",
doi = "10.3109/00365549009023116",
language = "English",
volume = "22",
pages = "31--36",
journal = "Scandinavian Journal of Infectious Diseases, Supplement",
issn = "0300-8878",
publisher = "Taylor & Francis",
number = "1",

}

RIS

TY - JOUR

T1 - Complement and immunoglobulin studies in 15 cases of chronic meningococcemia

T2 - Properdin deficiency and hypoimmunoglobulinemia

AU - Nielsen, Hans Erik

AU - Koch, Claus

AU - Mansa, Bendt

AU - Magnussen, Pascal

AU - Bergmann, Olav J.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - The purpose of this study was to investigate whether patients with chronic meningococcemia have abnormalities in their humoral immune system. The alternative and classical complement system, the levels of IgA, IgG and IgM, as well as IgG subclasses were studied in 15 individuals who had recovered from chronic meningococcemia. We found one individual with complete deficiency of properdin, a component of the alternative complement pathway. In the other patients, the complement system was normal. The mean plasma IgG concentration was significantly below normal in the patient group, while the mean values of IgA, IgM and the IgG subclasses were normal. Two individuals, however, had low IgG2 and IgG4 levels. We conclude that properdin deficiency and reduced plasma IgG levels may predispose to chronic meningococcal disease, but that the majority of patients with chronic meningococcemia have a normal humoral immune system.

AB - The purpose of this study was to investigate whether patients with chronic meningococcemia have abnormalities in their humoral immune system. The alternative and classical complement system, the levels of IgA, IgG and IgM, as well as IgG subclasses were studied in 15 individuals who had recovered from chronic meningococcemia. We found one individual with complete deficiency of properdin, a component of the alternative complement pathway. In the other patients, the complement system was normal. The mean plasma IgG concentration was significantly below normal in the patient group, while the mean values of IgA, IgM and the IgG subclasses were normal. Two individuals, however, had low IgG2 and IgG4 levels. We conclude that properdin deficiency and reduced plasma IgG levels may predispose to chronic meningococcal disease, but that the majority of patients with chronic meningococcemia have a normal humoral immune system.

UR - http://www.scopus.com/inward/record.url?scp=0025056808&partnerID=8YFLogxK

U2 - 10.3109/00365549009023116

DO - 10.3109/00365549009023116

M3 - Journal article

C2 - 2320962

AN - SCOPUS:0025056808

VL - 22

SP - 31

EP - 36

JO - Scandinavian Journal of Infectious Diseases, Supplement

JF - Scandinavian Journal of Infectious Diseases, Supplement

SN - 0300-8878

IS - 1

ER -

ID: 224709706