TY - JOUR

T1 - Chloroquine prophylaxis, iron-folic acid supplementation or case management of malaria attacks in primigravidae in western Uganda

T2 - Effects on maternal parasitaemia and haemoglobin levels and on birthweight

AU - Ndyomugyenyi, Richard

AU - Magnussen, Pascal

PY - 2000/1/1

Y1 - 2000/1/1

N2 - The effects of weekly chloroquine prophylaxis, daily iron-weekly folic acid supplementation or passive case management on maternal haemoglobin and parasitaemia and on birthweight were examined in primigravidae in a randomized, double-blind placebo-controlled intervention trial in 1996-98 in Hoima District, western Uganda. Iron-folic acid supplementation significantly increased mean birthweight as compared to case management (P = 0.03). Low birthweight (<2.5 kg) occurred in 2% of babies of women receiving chloroquine prophylaxis for ≥ 8 weeks and in 9% in the case management group (RR = 0·36, 95% CI0·13-1.00, P = 0.009). Parasitaemia at enrolment significantly correlated with low birthweight in the case management group as compared to the intervention groups (P = 0.02). Women in the case management group who were parasitaemic and had haemoglobin levels < 100 g/L at delivery had babies with lower mean birthweight as compared to babies in the other groups (P = 0.04). Low haemoglobin level at enrolment, irrespective of parasitaemia status, was a predictor of low birthweight in the case management group only (P = 0.04). Chloroquine prophylaxis and iron-folic acid supplementation significantly increased maternal haemoglobin levels during pregnancy as compared to case management (P = 0.01 and 0.007, respectively) and the increase correlated to the duration of the intervention.

AB - The effects of weekly chloroquine prophylaxis, daily iron-weekly folic acid supplementation or passive case management on maternal haemoglobin and parasitaemia and on birthweight were examined in primigravidae in a randomized, double-blind placebo-controlled intervention trial in 1996-98 in Hoima District, western Uganda. Iron-folic acid supplementation significantly increased mean birthweight as compared to case management (P = 0.03). Low birthweight (<2.5 kg) occurred in 2% of babies of women receiving chloroquine prophylaxis for ≥ 8 weeks and in 9% in the case management group (RR = 0·36, 95% CI0·13-1.00, P = 0.009). Parasitaemia at enrolment significantly correlated with low birthweight in the case management group as compared to the intervention groups (P = 0.02). Women in the case management group who were parasitaemic and had haemoglobin levels < 100 g/L at delivery had babies with lower mean birthweight as compared to babies in the other groups (P = 0.04). Low haemoglobin level at enrolment, irrespective of parasitaemia status, was a predictor of low birthweight in the case management group only (P = 0.04). Chloroquine prophylaxis and iron-folic acid supplementation significantly increased maternal haemoglobin levels during pregnancy as compared to case management (P = 0.01 and 0.007, respectively) and the increase correlated to the duration of the intervention.

KW - Anaemia

KW - Birthweight

KW - Chloroquine

KW - Folic acid supplementation

KW - Iron supplementation

KW - Malaria

KW - Parasitaemia

KW - Pregnancy

KW - Prophylaxis

KW - Uganda

UR - http://www.scopus.com/inward/record.url?scp=0033843475&partnerID=8YFLogxK

U2 - 10.1016/S0035-9203(00)90125-1

DO - 10.1016/S0035-9203(00)90125-1

M3 - Journal article

C2 - 11127247

AN - SCOPUS:0033843475

VL - 94

SP - 413

EP - 418

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

SN - 0035-9203

IS - 4

ER -