DISCOVERY team

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  1. 2016
  2. Published

    Breaking down brain barrier breaches in cerebral malaria

    Petersen, J. E. V., Lavstsen, Thomas & Craig, A., 3 Oct 2016, In: Journal of Clinical Investigation. 126, 10, p. 3725-3727 3 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  3. Published

    Plasmodium falciparum Plasmodium helical interspersed subtelomeric proteins contribute to cytoadherence and anchor P. falciparum erythrocyte membrane protein 1 to the host cell cytoskeleton

    Oberli, A., Zurbrügg, L., Rusch, S., Brand, F., Butler, M. E., Day, J. L., Cutts, E. E., Lavstsen, Thomas, Vakonakis, I. & Beck, H., Oct 2016, In: Cellular Microbiology. 18, 10, p. 1415-1428 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    The structural basis for CD36 binding by the malaria parasite

    Hsieh, F., Turner, Louise, Bolla, J. R., Robinson, C. V., Lavstsen, Thomas & Higgins, M. K., 27 Sep 2016, In: Nature Communications. 7, 11 p., 12837.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    The endothelial protein C receptor rs867186-GG genotype is associated with increased soluble EPCR and could mediate protection against severe malaria

    Shabani, E., Opoka, R. O., Bangirana, P., Park, G. S., Vercellotti, G. M., Guan, W., Hodges, J. S., Lavstsen, Thomas & John, C. C., 3 Jun 2016, In: Scientific Reports. 6, 11 p., 27084.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Adhesion of Plasmodium falciparum infected erythrocytes in ex vivo perfused placental tissue: a novel model of placental malaria

    Pehrson, Caroline, Mathiesen, Line, Heno, K. K., Salanti, Ali, dos Santos Marques Resende, M., Dzikowski, R., Damm, Peter, Hansson, S. R., King, C. L., Schneider, H., Wang, Christian William, Lavstsen, Thomas, Theander, Thor Grundtvig, Knudsen, Lisbeth E. & Nielsen, Morten Agertoug, 26 May 2016, In: Malaria Journal. 15, 12 p., 292.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    The role of EPCR in the pathogenesis of severe malaria

    Mosnier, L. O. & Lavstsen, Thomas, May 2016, In: Thrombosis Research. 141 , S2, p. S46-S49 4 p.

    Research output: Contribution to journal › Conference article › Research › peer-review

  8. Published

    Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRα1 domains

    Jespersen, Jakob Schmidt, Wang, Christian William, Mkumbaye, S. I., Minja, D. T., Petersen, Bent, Turner, Louise, Petersen, J. E., Lusingu, J. P., Theander, Thor Grundtvig & Lavstsen, Thomas, 2016, In: EMBO Molecular Medicine. 8, 8, p. 839-850 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria

    Duffy, M. F., Noviyanti, R., Tsuboi, T., Feng, Z., Trianty, L., Sebayang, B. F., Takashima, E., Sumardy, F., Lampah, D. A., Turner, Louise, Lavstsen, Thomas, Fowkes, F. J. I., Siba, P., Rogerson, S. J., Theander, Thor Grundtvig, Marfurt, J., Price, R. N., Anstey, N. M., Brown, G. V. & Papenfuss, A. T., 2016, In: Malaria Journal. 15, 12 p., 258.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. 2015
  11. Published

    Protein C system defects inflicted by the malaria parasite protein PfEMP1 can be overcome by a soluble EPCR variant

    Petersen, J. E. V., Bouwens, E. A. M., Tamayo, I., Turner, Louise, Wang, Christian William, Stins, M., Theander, Thor Grundtvig, Hermida, J., Mosnier, L. O. & Lavstsen, Thomas, Nov 2015, In: Thrombosis and Haemostasis. 114, 5, p. 1038-48 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    IgG antibodies to endothelial protein C receptor-binding Cysteine-rich interdomain region domains of Plasmodium falciparum erythrocyte membrane protein 1 are acquired early in life in individuals exposed to malaria

    Turner, Louise, Lavstsen, Thomas, Mmbando, B. P., Wang, Christian William, Magistrado, P. A., Vestergaard, L. S., Ishengoma, D. S., Minja, D. T. R., Lusingu, J. P. & Theander, Thor Grundtvig, Aug 2015, In: Infection and Immunity. 83, 8, p. 3096-103 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Rifins, rosetting, and red blood cells

    Wang, Christian William & Hviid, Lars, Jul 2015, In: Trends in Parasitology. 31, 7, p. 285-6 2 p.

    Research output: Contribution to journal › Journal article › Commissioned › peer-review

  14. Published

    Structural Conservation Despite Huge Sequence Diversity Allows EPCR Binding by the PfEMP1 Family Implicated in Severe Childhood Malaria

    Lau, C. K. Y., Turner, Louise, Jespersen, Jakob Schmidt, Lowe, E. D., Petersen, Bent, Wang, Christian William, Petersen, J. E. V., Lusingu, J., Theander, Thor Grundtvig, Lavstsen, Thomas & Higgins, M. K., 14 Jan 2015, In: Cell Host & Microbe. 17, 1, p. 118-29 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Plasmodium falciparum-infected erythrocyte knob density is linked to the PfEMP1 variant expressed

    Subramani, R., Quadt, K., Jeppesen, A. E., Hempel, C., Petersen, J. E. V., Hassenkam, Tue, Hviid, Lars & Barfod, Lea Klingenberg, 2015, In: mBio. 6, 5, 7 p., e01456-15.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Haplotypes of the endothelial protein C receptor (EPCR) gene are not associated with severe malaria in Tanzania

    Hansson, Helle Smedegaard, Turner, Louise, Møller, L., Wang, Christian William, Minja, D., Gesase, S., Mmbando, B., Bygbjerg, Ib Christian, Theander, Thor Grundtvig, Lusingu, J. P. A., Alifrangis, Michael & Lavstsen, Thomas, 2015, In: Malaria Journal. 14, 9 p., 474.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Multiple Plasmodium falciparum erythrocyte membrane protein 1 variants per genome can bind IgM via its Fc fragment Fcμ

    Jeppesen, A., Ditlev, S. B., Soroka, V., Stevenson, E. K., Turner, Louise, Dzikowski, R., Hviid, Lars & Barfod, Lea Klingenberg, 2015, In: Infection and Immunity. 83, 10, p. 3972-81 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. 2014
  19. Published

    DNA secondary structures are associated with recombination in major Plasmodium falciparum variable surface antigen gene families

    Sander, Adam F. , Lavstsen, Thomas, Rask, T. S., Lisby, Michael, Salanti, Ali, Fordyce, S. L., Jespersen, Jakob Schmidt, Carter, R., Deitsch, K. W., Theander, Thor Grundtvig, Pedersen, A. G. & Arnot, D. E., 2014, In: Nucleic Acids Research. 42, 4, p. 2270-81 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Differences in gene transcriptomic pattern of Plasmodium falciparum in children with cerebral malaria and asymptomatic carriers

    Almelli, T., Nuel, G., Bischoff, E., Aubouy, A., Elati, M., Wang, Christian William, Dillies, M., Coppée, J., Ayissi, G. N., Basco, L. K., Rogier, C., Ndam, N. T., Deloron, P. & Tahar, R., 2014, In: PloS one. 9, 12, p. e114401

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria

    Zhang, Q., Siegel, T. N., Martins, R. M., Wang, F., Cao, J., Gao, Q., Cheng, X., Jiang, L., Hon, C., Scheidig-Benatar, C., Sakamoto, H., Turner, Louise, Jensen, Anja Ramstedt, Claes, A., Guizetti, J., Malmquist, N. A. & Scherf, A., 2014, In: Nature. 531, p. 431-435

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Modeling malaria infection and immunity against variant surface antigens in Príncipe island, West Africa

    Bandeiras, C., Trovoada, M. J., Gonçalves, L. A., Marinho, C. R. F., Turner, Louise, Hviid, Lars, Penha-Gonçalves, C. & Gomes, M. G. M., 2014, In: PloS one. 9, 2, p. e88110

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. 2013
  24. Published

    Malaria's deadly grip: cytoadhesion of Plasmodium falciparum-infected erythrocytes

    Smith, J. D., Rowe, J. A., Higgins, M. K. & Lavstsen, Thomas, Dec 2013, In: Cellular Microbiology Online. 15, 12, p. 1976-83 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Early gametocytes of the malaria parasite Plasmodium falciparum specifically remodel the adhesive properties of infected erythrocyte surface

    Tibúrcio, M., Silvestrini, F., Bertuccini, L., Sander, Adam F. , Turner, Louise, Lavstsen, Thomas & Alano, P., 1 Nov 2013, In: Cellular Microbiology Online. 15, 4, p. 647-659

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum

    Jiang, L., Mu, J., Zhang, Q., Ni, T., Srinivasan, P., Rayavara, K., Yang, W., Turner, L., Lavstsen, T., Theander, T. G., Peng, W., Wei, G., Jing, Q., Wakabayashi, Y., Bansal, A., Luo, Y., Ribeiro, J. M. C., Scherf, A., Aravind, L., Zhu, J. & 2 others, Zhao, K. & Miller, L. H., 11 Jul 2013, In: Nature. 499, 7457, p. 223-7 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Severe malaria is associated with parasite binding to endothelial protein C receptor

    Turner, Louise, Lavstsen, Thomas, Berger, S. S., Wang, Christian William, Petersen, J. E. V., Avril, M., Brazier, A. J., Freeth, J., Jespersen, Jakob Schmidt, Nielsen, Morten Agertoug, Magistrado, P., Lusingu, J., Smith, J. D., Higgins, M. K. & Theander, Thor Grundtvig, 27 Jun 2013, In: Nature. 498, 7455, p. 502-5 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Molecular architecture of a complex between an adhesion protein from the malaria parasite and intracellular adhesion molecule 1

    Brown, A., Turner, Louise, Christoffersen, S., Andrews, K. A., Szestak, T., Zhao, Y., Larsen, Sine, Craig, A. G. & Higgins, M. K., 22 Feb 2013, In: Journal of Biological Chemistry. 288, 8, p. 5992-6003 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    A Novel Domain Cassette Identifies Plasmodium falciparum PfEMP1 Proteins Binding ICAM-1 and Is a Target of Cross-Reactive, Adhesion-Inhibitory Antibodies

    Bengtsson, A., Joergensen, L., Rask, T. S., Olsen, R. W., Andersen, M. A., Turner, Louise, Theander, Thor Grundtvig, Hviid, Lars, Higgins, M. K., Craig, A., Brown, A. & Jensen, Anja Ramstedt, 2013, In: Journal of Immunology. 190, 1, p. 240-9 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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