DISCOVERY team

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  1. 2024
  2. Published

    A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture

    Andradi-Brown, C., Wichers-Misterek, J. S., von Thien, H., Höppner, Y. D., Scholz, J. A. M., Hansson, Helle Smedegaard, Hocke, Emma Filtenborg, Gilberger, T. W., Duffy, M. F., Lavstsen, Thomas, Baum, J., Otto, T. D., Cunnington, A. J. & Bachmann, A., 25 Jan 2024, In: eLife. 12, 38 p., RP87726.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Contact allergens in African countries: A review of published patch test studies

    Bonefeld, N. M., Menné, T., Ahrensbøll-Friis, U., Gadsbøll, Anne-Sofie Østergaard, Wang, Christian William, Theander, Thor Grundtvig, Masenga, E. J., Mavura, D., Ødum, Niels, Bonefeld, Charlotte Menne & Geisler, Carsten, 2024, In: Contact Dermatitis. 90, 2, p. 103-109

    Research output: Contribution to journal › Review › Research › peer-review

  4. 2023
  5. Published

    Assessment of artemisinin tolerance in Plasmodium falciparum clinical isolates in children with uncomplicated malaria in Ghana

    Ahorhorlu, S. Y., Quashie, N. B., Jensen, R. W., Kudzi, W., Nartey, E. T., Duah-Quashie, N. O., Zoiku, F., Dzudzor, B., Wang, Christian William, Hansson, Helle Smedegaard, Alifrangis, Michael & Adjei, G. O., 2023, In: Malaria Journal. 22, 58.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Endothelial protein C receptor binding induces conformational changes to severe malaria-associated group A PfEMP1

    Raghavan, Sai Sundar Rajan, Turner, Louise, Jensen, R. W., Johansen, Nicolai Tidemand, Jensen, D. S., Gourdon, Pontus Emanuel, Zhang, J., Wang, Y., Theander, Thor Grundtvig, Wang, Kaituo & Lavstsen, Thomas, 2023, In: Structure. 31, 10, p. 1174-1183.e4

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Human Ad19a/64 HERV-W Vaccines Uncover Immunosuppression Domain-Dependent T-Cell Response Differences in Inbred Mice

    Skandorff, I., Ragonnaud, Emeline, Gille, J., Andersson, A. M., Schrödel, S., Duvnjak, Lara, Turner, Louise, Thirion, C., Wagner, R. & Holst, Peter Johannes, 2023, In: International Journal of Molecular Sciences. 24, 12, 9972.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. 2022
  9. Published

    Analysis of var gene transcript patterns by quantitative real-time PCR

    Bachmann, A. & Lavstsen, Thomas, 2022, Malaria Immunology: Targeting the Surface of Infected Erythrocytes. Humana Press, Vol. 2470. p. 149–171 23 p. (Methods in molecular biology (Clifton, N.J.)).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  10. Published

    Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1.4 broadly reacting with polymorphic malarial protein VAR2CSA

    Raghavan, Sai Sundar Rajan, Dagil, Robert, Lopez-Perez, Mary, Conrad, J., Bassi, Maria Rosaria, Quintana Varon, Maria del Pilar, Choudhary, Swati, Gustavsson, Tobias, Wang, Yong, Gourdon, Pontus Emanuel, Ofori, M. F., Christensen, S. B., Minja, D. T. R., Schmiegelow, Christentze, Nielsen, Morten Agertoug, Barfod, Lea Klingenberg, Hviid, Lars, Salanti, Ali, Lavstsen, Thomas & Wang, Kaituo, 2022, In: PLoS Pathogens. 18, 11, e1010924.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Mapping the cord blood transcriptome of pregnancies affected by early maternal anemia to identify signatures of fetal programming

    Hatem, G., Hjort, Line, Asplund, O., Minja, D. T. R., Msemo, O. A., Møller, S. L., Lavstsen, Thomas, Grunnet, Louise Groth, Lusingu, J. P. A., Hansson, O., Christensen, Dirk Lund, Vaag, Allan, Artner, I., Theander, Thor Grundtvig, Groop, L., Schmiegelow, Christentze, Bygbjerg, Ib Christian & Prasad, R. B., 2022, In: The Journal of clinical endocrinology and metabolism. 107, 5, p. 1303–1316 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Seroprevalence of SARS-CoV-2 antibodies among children and adolescents recruited in a malariometric survey in north-eastern Tanzania July 2021

    Lyimo, E., Fougeroux, Cyrielle Elyette, Malabeja, A., Mbwana, J., Hayuma, P. M., Liheluka, E., Turner, Louise, Gesase, S., Lavstsen, Thomas, Lusingu, J. P. A., Minja, D. T. R. & Wang, Christian William, 2022, In: BMC Infectious Diseases. 22, 846.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Varia: a tool for prediction, analysis and visualisation of variable genes

    Mackenzie, G., Jensen, R. W., Lavstsen, Thomas & Otto, T. D., 2022, In: BMC Bioinformatics. 23, 13 p., 52.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. 2021
  15. Published

    Common virulence gene expression in adult first-time infected malaria patients and severe cases

    Wichers, J. S., Tonkin-Hill, G., Thye, T., Krumkamp, R., Kreuels, B., Strauss, J., von Thien, H., Scholz, J. A. M., Smedegaard Hansson, H., Weisel Jensen, R., Turner, L., Lorenz, F-R., Schöllhorn, A., Bruchhaus, I., Tannich, E., Fendel, R., D Otto, T., Lavstsen, T., Gilberger, T. W., Duffy, M. & 1 others, Bachmann, A., 2021, In: eLife. 10, e69040.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Complement C1s cleaves PfEMP1 at interdomain conserved sites inhibiting Plasmodium falciparum cytoadherence

    Azasi, Y., Low, L. M., Just, A. N., Raghavan, Sai Sundar Rajan, Wang, Christian William, Valenzuela-Leon, P., Alexandra Rowe, J., Smith, J. D., Lavstsen, Thomas, Turner, Louise, Calvo, E. & Miller, L. H., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 22, e2104166118.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding

    Wang, Kaituo, Dagil, Robert, Lavstsen, Thomas, Misra, S. K., Spliid, C. B., Wang, Yong, Gustavsson, Tobias, Sandoval, D. R., Vidal-Calvo, E. E., Choudhary, Swati, Agerbæk, Mette Ørskov, Lindorff-Larsen, Kresten, Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Sharp, J. S., Clausen, Thomas Mandel, Gourdon, Pontus Emanuel & Salanti, Ali, 2021, In: Nature Communications. 12, 1, 10 p., 2956.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Identification of single-nucleotide polymorphisms in the mitochondrial genome and kelch 13 gene of Plasmodium falciparum in different geographical populations

    Nydahl, T. K., Ahorhorlu, S. Y., Ndiaye, M., Das, M. K., Hansson, Helle Smedegaard, Crespo Bravo, Marina, Wang, Christian William, Lusingu, J., Theisen, Michael, Singh, S. K., Singh, S., Campino, S., Lund, O., Roper, C. & Alifrangis, Michael, 2021, In: American Journal of Tropical Medicine and Hygiene. 105, 4, p. 1085-1092 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Prevalence of asymptomatic malaria, submicroscopic parasitaemia and anaemia in Korogwe District, north-eastern Tanzania

    Hayuma, P. M., Wang, Christian William, Liheluka, E., Baraka, V., Madebe, R. A., Minja, D. T. R., Misinzo, G., Alifrangis, Michael & Lusingu, J. P. A., 2021, In: Malaria Journal. 20, 9 p., 424.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Sickle-trait hemoglobin reduces adhesion to both CD36 and EPCR by Plasmodium falciparum-infected erythrocytes

    Petersen, J. E. V., Saelens, J. W., Freedman, E., Turner, Louise, Lavstsen, Thomas, Fairhurst, R. M., Diakité, M. & Taylor, S. M., 2021, In: P L o S Pathogens. 17, 6, 18 p., e1009659.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Structure-guided design of a synthetic mimic of an endothelial protein C receptor-binding PfEMP1 protein

    Barber, N. M., Lau, C. K. Y., Turner, Louise, Watson, G., Thrane, Susan, Lusingu, J. P. A., Lavstsen, Thomas & Higgins, M. K., 2021, In: mSphere. 6, 1, 14 p., e01081-20.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Ten years of monitoring malaria trend and factors associated with malaria test positivity rates in Lower Moshi

    Kassam, N. A., Kaaya, R. D., Damian, D. J., Schmiegelow, Christentze, Kavishe, R. A., Alifrangis, Michael & Wang, Christian William, 2021, In: Malaria Journal. 20, 1, 193.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Use of anti-gSG6-P1 IgG as a serological biomarker to assess temporal exposure to Anopheles' mosquito bites in Lower Moshi

    Kassam, N. A., Kulaya, N., Kaaya, R. D., Schmiegelow, Christentze, Wang, Christian William, Kavishe, R. A. & Alifrangis, Michael, 2021, In: PLoS ONE. 16, 10, e0259131.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. 2020
  25. Published

    In vitro selection for adhesion of Plasmodium falciparum-infected erythrocytes to ABO antigens does not affect PfEMP1 and RIFIN expression

    van der Puije, W., Wang, Christian William, Sudharson, S., Hempel, C., Olsen, Rebecca Wendelboe, Dalgaard, Nanna, Ofori, M. F., Hviid, Lars, Kurtzhals, Jørgen & Staalsø, Trine, 2020, In: Scientific Reports. 10, 1, p. 12871 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    In vivo imaging of the buccal mucosa shows loss of the endothelial glycocalyx and perivascular hemorrhages in pediatric Plasmodium falciparum malaria

    Lyimo, E., Haslund, L. E., Ramsing, T., Wang, Christian William, Efunshile, A. M., Manjurano, A., Makene, V., Lusingu, J., Theander, Thor Grundtvig, Kurtzhals, Jørgen, Paulsen, R. & Hempel, C., 2020, In: Infection and Immunity. 88, 3, e00679-19.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Dynamics of PfEMP1 Antibody Profile From Birth to 12 Months of Age in Beninese Infants

    Moussiliou, A., Turner, Louise, Cottrell, G., Doritchamou, J., Gbédandé, K., Fievet, N., Luty, A. J. F., Massougbodji, A., Theander, Thor Grundtvig, Deloron, P., Lavstsen, Thomas & Tuikue Ndam, N., 2020, In: The Journal of Infectious Diseases. 221, 12, p. 2010-2017 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Gene expression profiling of malaria parasites reveals common virulence gene expression in adult first-time infected patients and severe cases

    Wichers, J. S., Tonkin-Hill, G., Thye, T., Krumkamp, R., Kreuels, B., Strauss, J., Thien, H. V., Scholz, J. A. M., Hansson, H. S., Jensen, R. W., Turner, L., Lorenz, F-R., Schöllhorn, A., Bruchhaus, I., Tannich, E., Fendel, R., Otto, T. D., Lavstsen, T., Gilberger, T-W., Duffy, M. F. & 1 others, Bachmann, A., 2020, bioRxiv.

    Research output: Working paper › Preprint › Research

  29. Published

    Identification of a conserved var gene in different Plasmodium falciparum strains

    Dimonte, S., Bruske, E. I., Enderes, C., Otto, T. D., Turner, Louise, Kremsner, P. & Frank, M., 2020, In: Malaria Journal. 19, 1, 15 p., 194.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Immunization with virus-like particles conjugated to CIDRα1 domain of Plasmodium falciparum erythrocyte membrane protein 1 induces inhibitory antibodies

    Harmsen, C., Turner, Louise, Thrane, Susan, Sander, Adam F. , Theander, Thor Grundtvig & Lavstsen, Thomas, 2020, In: Malaria Journal. 19, 1, 11 p., 132.

    Research output: Contribution to journal › Journal article › Research › peer-review

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