DISCOVERY team

  1. Published

    3D7-derived Plasmodium falciparum erythrocyte membrane protein 1 is a frequent target of naturally acquired antibodies recognizing protein domains in a particular pattern independent of malaria transmission intensity

    Joergensen, L., Vestergaard, L. S., Turner, Louise, Magistrado, P., Lusingu, J. P., Lemnge, M., Theander, Thor Grundtvig & Jensen, Anja Ramstedt, 2007, In: Journal of Immunology. 178, 1, p. 428-35 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Plasmodium falciparum erythrocyte membrane protein 1 diversity in seven genomes - divide and conquer

    Rask, T. S., Hansen, D. A., Theander, Thor Grundtvig, Gorm Pedersen, A. & Lavstsen, Thomas, 2010, In: P L o S Computational Biology. 6, 9

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Plasmodium falciparum transcriptome analysis reveals pregnancy malaria associated gene expression

    Tuikue Ndam, N., Bischoff, E., Proux, C., Lavstsen, Thomas, Salanti, Ali, Guitard, J., Nielsen, Morten Agertoug, Coppée, J., Gaye, A., Theander, Thor Grundtvig, David, P. H. & Deloron, P., 2008, In: PLoS ONE. 3, 3, p. e1855

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Plasmodium falciparum: VAR2CSA expressed during pregnancy-associated malaria is partially resistant to proteolytic cleavage by trypsin

    Nielsen, Morten Agertoug, Resende, M., Alifrangis, Michael, Turner, Louise, Hviid, Lars, Theander, Thor Grundtvig & Salanti, Ali, 2007, In: Experimental Parasitology. 117, 1, p. 1-8 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    In vitro selection for adhesion of Plasmodium falciparum-infected erythrocytes to ABO antigens does not affect PfEMP1 and RIFIN expression

    van der Puije, W., Wang, Christian William, Sudharson, S., Hempel, C., Olsen, Rebecca Wendelboe, Dalgaard, Nanna, Ofori, M. F., Hviid, Lars, Kurtzhals, Jørgen & Staalsø, Trine, 2020, In: Scientific Reports. 10, 1, p. 12871 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    In vivo imaging of the buccal mucosa shows loss of the endothelial glycocalyx and perivascular hemorrhages in pediatric Plasmodium falciparum malaria

    Lyimo, E., Haslund, L. E., Ramsing, T., Wang, Christian William, Efunshile, A. M., Manjurano, A., Makene, V., Lusingu, J., Theander, Thor Grundtvig, Kurtzhals, Jørgen, Paulsen, R. & Hempel, C., 2020, In: Infection and Immunity. 88, 3, e00679-19.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Plasmodium falciparum Plasmodium helical interspersed subtelomeric proteins contribute to cytoadherence and anchor P. falciparum erythrocyte membrane protein 1 to the host cell cytoskeleton

    Oberli, A., Zurbrügg, L., Rusch, S., Brand, F., Butler, M. E., Day, J. L., Cutts, E. E., Lavstsen, Thomas, Vakonakis, I. & Beck, H., Oct 2016, In: Cellular Microbiology. 18, 10, p. 1415-1428 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRα1 domains

    Jespersen, Jakob Schmidt, Wang, Christian William, Mkumbaye, S. I., Minja, D. T., Petersen, Bent, Turner, Louise, Petersen, J. E., Lusingu, J. P., Theander, Thor Grundtvig & Lavstsen, Thomas, 2016, In: EMBO Molecular Medicine. 8, 8, p. 839-850 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children

    Lavstsen, Thomas, Turner, Louise, Saguti, F., Magistrado, P. A., Rask, T. S., Jespersen, Jakob Schmidt, Wang, Christian William, Berger, S. S., Baraka, V., Marquard, A. M., Seguin-Orlando, A., Willerslev, Eske, Gilbert, M Thomas P, Lusingu, J. P. A. & Theander, Thor Grundtvig, 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 26, p. E1791-E1800 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Plasmodium falciparum-CD36 structure-function relationships defined by ortholog scanning mutagenesis

    Cabrera, A., Neculai, D., Tran, V., Lavstsen, Thomas, Turner, Louise & Kain, K. C., 2019, In: The Journal of Infectious Diseases. 219, 6, p. 945-954

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Plasmodium falciparum-infected erythrocyte knob density is linked to the PfEMP1 variant expressed

    Subramani, R., Quadt, K., Jeppesen, A. E., Hempel, C., Petersen, J. E. V., Hassenkam, Tue, Hviid, Lars & Barfod, Lea Klingenberg, 2015, In: mBio. 6, 5, 7 p., e01456-15.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    A Novel Domain Cassette Identifies Plasmodium falciparum PfEMP1 Proteins Binding ICAM-1 and Is a Target of Cross-Reactive, Adhesion-Inhibitory Antibodies

    Bengtsson, A., Joergensen, L., Rask, T. S., Olsen, R. W., Andersen, M. A., Turner, Louise, Theander, Thor Grundtvig, Hviid, Lars, Higgins, M. K., Craig, A., Brown, A. & Jensen, Anja Ramstedt, 2013, In: Journal of Immunology. 190, 1, p. 240-9 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    A method for visualizing surface-exposed and internal PfEMP1 adhesion antigens in Plasmodium falciparum infected erythrocytes

    Bengtsson, D., Sowa, K. M., Salanti, Ali, Jensen, Anja Ramstedt, Joergensen, L., Turner, Louise, Theander, Thor Grundtvig & Arnot, D. E., 2008, In: Malaria Journal. 7, p. 101

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture

    Andradi-Brown, C., Wichers-Misterek, J. S., von Thien, H., Höppner, Y. D., Scholz, J. A. M., Hansson, Helle Smedegaard, Hocke, Emma Filtenborg, Gilberger, T. W., Duffy, M. F., Lavstsen, Thomas, Baum, J., Otto, T. D., Cunnington, A. J. & Bachmann, A., 25 Jan 2024, In: eLife. 12, 38 p., RP87726.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    A semi-automated multiplex high-throughput assay for measuring IgG antibodies against Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) domains in small volumes of plasma

    Cham, G. K. K., Kurtis, J., Lusingu, J., Theander, Thor Grundtvig, Jensen, Anja Ramstedt & Turner, Louise, 2008, In: Malaria Journal. 7, p. 108

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells

    Claessens, A., Adams, Y., Ghumra, A., Lindergard, G., Buchan, C. C., Andisi, C., Bull, P. C., Mok, S., Gupta, A. P., Wang, Christian William, Turner, Louise, Arman, M., Raza, A., Bozdech, Z. & Rowe, J. A., 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 26, p. E1772-81

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    A vaccine targeted specifically to prevent cerebral malaria - is there hope?

    Hviid, Lars, Lavstsen, Thomas & Jensen, Anja Ramstedt, Jul 2018, In: Expert Review of Vaccines. 17, 7, p. 565-567 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

  18. Published

    Acquisition of antibodies against endothelial protein C receptor-binding domains of Plasmodium falciparum erythrocyte membrane protein 1 in children with severe malaria

    Rambhatla, J. S., Turner, Louise, Manning, L., Laman, M., Davis, T. M. E., Beeson, J. G., Mueller, I., Warrel, J., Theander, Thor Grundtvig, Lavstsen, Thomas & Rogerson, S. J., 2019, In: The Journal of Infectious Diseases. 219, 5, p. 808-818 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Adhesion of Plasmodium falciparum infected erythrocytes in ex vivo perfused placental tissue: a novel model of placental malaria

    Pehrson, Caroline, Mathiesen, Line, Heno, K. K., Salanti, Ali, dos Santos Marques Resende, M., Dzikowski, R., Damm, Peter, Hansson, S. R., King, C. L., Schneider, H., Wang, Christian William, Lavstsen, Thomas, Theander, Thor Grundtvig, Knudsen, Lisbeth E. & Nielsen, Morten Agertoug, 26 May 2016, In: Malaria Journal. 15, 12 p., 292.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    An upstream open reading frame controls translation of var2csa, a gene implicated in placental malaria

    Amulic, B., Salanti, Ali, Lavstsen, Thomas, Nielsen, Morten Agertoug & Deitsch, K. W., 2009, In: PLoS Pathogens. 5, 1, p. e1000256

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Analysis of var gene transcript patterns by quantitative real-time PCR

    Bachmann, A. & Lavstsen, Thomas, 2022, Malaria Immunology: Targeting the Surface of Infected Erythrocytes. Humana Press, Vol. 2470. p. 149–171 23 p. (Methods in molecular biology (Clifton, N.J.)).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  22. Published

    Antibodies against PfEMP1, RIFIN, MSP3 and GLURP are acquired during controlled Plasmodium falciparum malaria infections in naïve volunteers

    Turner, Louise, Wang, Christian William, Lavstsen, Thomas, Mwakalinga, S. B., Sauerwein, R. W., Hermsen, C. C. & Theander, Thor Grundtvig, 2011, In: P L o S One. 6, 12, p. e29025

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Antibodies to intercellular adhesion molecule 1-binding Plasmodium falciparum erythrocyte membrane protein 1-DBLβ are biomarkers of protective immunity to malaria in a cohort of young children from Papua New Guinea

    Tessema, S. K., Utama, D., Chesnokov, O., Hodder, A. N., Lin, C. S., Harrison, G. L. A., Jespersen, Jakob Schmidt, Petersen, Bent, Tavul, L., Siba, P., Kwiatkowski, D., Lavstsen, Thomas, Hansen, D. S., Oleinikov, A. V., Mueller, I. & Barry, A. E., 1 Aug 2018, In: Infection and Immunity. 86, 8, p. 1-14 14 p., e00485-17.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Assessment of artemisinin tolerance in Plasmodium falciparum clinical isolates in children with uncomplicated malaria in Ghana

    Ahorhorlu, S. Y., Quashie, N. B., Jensen, R. W., Kudzi, W., Nartey, E. T., Duah-Quashie, N. O., Zoiku, F., Dzudzor, B., Wang, Christian William, Hansson, Helle Smedegaard, Alifrangis, Michael & Adjei, G. O., 2023, In: Malaria Journal. 22, 58.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Associations between IgG reactivity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens and Burkitt lymphoma in Ghana and Uganda case-control studies

    Derkach, A., Otim, I., Pfeiffer, R. M., Onabajo, O. O., Legason, I. D., Nabalende, H., Ogwang, M. D., Kerchan, P., Talisuna, A. O., Ayers, L. W., Reynolds, S. J., Nkrumah, F., Neequaye, J., Bhatia, K., Theander, Thor Grundtvig, Prokunina-Olsson, L., Turner, Louise, Goedert, J. J., Lavstsen, Thomas & Mbulaiteye, S. M., 2019, In: EBioMedicine. 39, p. 358-368 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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