Research facilities and technologies at CMP
We use antibodies obtained from plasma of Plasmodium falciparum-exposed individuals, from animal immune sera, produced by phage display technology, and produced by B cells or transfected cell lines in vitro.
Bioinformatics and in silico modeling
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Flow cytometry and cell sorting
We use 4-, 5-, and 7-parameter flow cytometry and fluorescence-activated cell sorting for analysis and selection of cells. In addition, we use magnet-activated cell sorting (Dynal and Miltenyi systems) to select cell subsets.
We use a variety of microscopic techniques in our research, including light microscopy, phase contrast microscopy, fluorescence microscopy, confocal microscopy, atomic force microscopy, and scanning electron microscopy.
We use P. falciparum parasites isolated from malaria patients with defined clinical syndromes as well as a number of standard laboratory lines and clones. We also use different rodent parasites such as P. berghei and P. chabaudi.
We use insects and bacteria as expression systems in the production of our recombinant proteins. For the purification we use ÄKTAcrossflow and/or our three ÄKTAxpress systems. We use combinations of different chromatographic methods in our purification.