Drug resistance team (DRUGS) – University of Copenhagen

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Drug resistance team (DRUGS)

HPLC screenshot 

Mission and vision

  • Monitor the efficacy of antimalarial drugs in the treatment of humans
  • Investigate factors, which influence the treatment outcome with implications for future malaria control in the malaria endemic world.

Description of our group

We are a diverse group of lab technicians, medical doctors, biologists, and biochemists at master, PhD, post doc, assisting professor and professor level with occasional guests from collaborating groups. Our areas of research span from clinical to public health related research focusing mainly on antimalarial drugs. This includes:

  • Monitoring the efficacy of antimalarial drugs, including studies of factors influencing the drug efficacy such as drug resistance, human genetics (pharmacogenetics and human genetic polymorphisms involved in protection against malaria) and in vivo drug measurements (pharmaco-kinetics/phamaco-dynamics). 
  • Examining distribution patterns of human genetic polymorphisms related to severity of the malaria disease and protection against malaria.
  • Studies of the molecular evolution of antimalarial drug resistance.
  • Development of new molecular and biochemical tools to examine various factors above.

Our projects mainly involve the two major malaria parasites, Plasmodium falciparum and P. vivax. However, we are continuously broadening our research topics into other areas of tropical medicine and international health such as:

  • Maternal and child health
  • Interactions between malaria, HIV and tuberculosis at the disease and drugs levels
  • Other vector-borne diseases such as filariasis and dengue fever.

Laboratory techniques

PCR (polymerase chain reaction) and real-time quantitative PCR, RFLP (restriction fragment length polymorphism), SSOP-ELISA (sequence-specific oligonucleotide probes - enzyme-linked immunosorbent assay), DNA-sequencing, fragment analyses of microsatellites, in vivo drug measurements using HPLC (high performance liquid chromatography) and novel antibody-based ELISA.

External collaborators

We have collaborators in many parts of the world, including:

  • London School of Hygiene and Tropical Medicine
  • National Institute for Medical Research, Tanga, Tanzania
  • Kilimanjaro Christian Medical Collage, Moshi, Tanzania
  • Institute of Tropical Disease & Biochemistry Department, University of Khartoum, Sudan
  • Centre for Tropical Clinical Pharmacology and Therapeutics, University of Ghana Medical School, Ghana
  • Malaria Research and Training Center, University of Bamako, Mali
  • L'Institut National de Recherche en Santé Publique (INRSP), Mali
  • University Teaching Hospital, Lusaka, Zambia
  • Africare Angola, Luanda, Angola
  • Centre for Research in Medical Entomology (ICMR), Madurai, Tamil Nadu. India.

In Denmark our main collaborators are:

  • DBL - Centre for Health Research and Development, Faculty of Life Sciences Faculty of Life, University of Copenhagen
  • Sankt Hans Hospital, Roskilde
  • Institute of Immunology and Microbiology, University of Southern Denmark

If you are a student looking for a project, or interested in general information about the DRUGS team, please contact Michael Alifrangis or Ib Bygbjerg (iby@sund.ku.dk) for further information.